A5099014750- Inflammasome and immune disorders
- Phagocytosis and Immune Regulation
- Kawasaki Disease and Coronary Complications
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
Universitat de Barcelona
2024-2025
ABSTRACT Viral accessory proteins play critical roles in viral escape from host innate immune responses and inflammatory pathogenesis. Here we show that the SARS‐CoV‐2 protein, ORF9b, but not other (ORF3a, ORF3b, ORF6, ORF7, ORF8, ORF9c, ORF10), strongly activates inflammasome‐dependent caspase‐1 A549 lung carcinoma cells THP‐1 monocyte‐macrophage cells. Exposure to lipopolysaccharide (LPS) ATP additively enhanced activation of by suggesting ORF9b LPS follow parallel pathways inflammasome...
Abstract Viral accessory proteins play critical roles in viral escape form host innate immune responses and inflammatory pathogenesis. Here we show that the SARS-CoV-2 protein, ORF9b, but not other (ORF3a, ORF3b, ORF6, ORF7, ORF8, ORF9c, ORF10), strongly activates inflammasome-dependent caspase-1 A549 lung carcinoma cells THP-1 monocyte-macrophage cells. Exposure to lipopolysaccharide (LPS) ATP additively enhanced activation of by suggesting ORF9b LPS follow parallel pathways inflammasome...