A5102934426- S100 Proteins and Annexins
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Kawasaki Disease and Coronary Complications
- Inflammasome and immune disorders
- Renal and Vascular Pathologies
- COVID-19 Clinical Research Studies
- Cancer Research and Treatments
- Renal cell carcinoma treatment
- Immune cells in cancer
- Caveolin-1 and cellular processes
- Protease and Inhibitor Mechanisms
- RNA modifications and cancer
- Connexins and lens biology
- Cellular transport and secretion
- Bone and Dental Protein Studies
- SARS-CoV-2 and COVID-19 Research
- Organ Donation and Transplantation
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Genomics and Chromatin Dynamics
- Cell Adhesion Molecules Research
- Metabolism, Diabetes, and Cancer
Institut de Biologia Molecular de Barcelona
2014-2025
Consejo Superior de Investigaciones Científicas
2017
Universitat de Barcelona
2000-2001
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2000
In solid tumors, cancer stem cells (CSCs) can arise independently of epithelial-mesenchymal transition (EMT). spite recent efforts, the metabolic reprogramming associated with CSC phenotypes uncoupled from EMT is poorly understood. Here, by using metabolomic and fluxomic approaches, we identify major profiles that differentiate metastatic prostate epithelial CSCs (e-CSCs) non-CSCs expressing a stable EMT. We have found e-CSC program in our cellular model characterized high plasticity energy...
ABSTRACT Viral accessory proteins play critical roles in viral escape from host innate immune responses and inflammatory pathogenesis. Here we show that the SARS‐CoV‐2 protein, ORF9b, but not other (ORF3a, ORF3b, ORF6, ORF7, ORF8, ORF9c, ORF10), strongly activates inflammasome‐dependent caspase‐1 A549 lung carcinoma cells THP‐1 monocyte‐macrophage cells. Exposure to lipopolysaccharide (LPS) ATP additively enhanced activation of by suggesting ORF9b LPS follow parallel pathways inflammasome...
Tumor cell subpopulations can either compete with each other for nutrients and physical space within the tumor niche, or co-operate enhanced survival, replicative metastatic capacities. Recently, we have described co-operative interactions between two clonal derived from PC-3 prostate cancer line, in which invasiveness of a stem (CSC)-enriched subpopulation (PC-3M, M) is by non-CSC (PC-3S, S), resulting their accelerated dissemination. M S secretomes were compared SILAC (Stable Isotope...
MicroRNAs are critical regulators of gene networks in normal and abnormal biological processes. Focusing on invasive ductal breast cancer (IDC), we have found dysregulated expression tumor samples several microRNAs, including the miR-200 family, along progression from primary tumors to distant metastases, further reflected higher blood levels miR-200b miR-7 IDC patients with regional or metastases relative node-negative tumors. Forced miR-200s MCF10CA1h mammary cells induced an enhanced...
Annexin 6 is a Ca 2+ ‐dependent phospholipid‐binding protein involved in membrane trafficking. In this study we demonstrate the association of Raf‐1 with recombinant rat annexin 6. Raf–annexin interaction was shown to be independent cell activation by epidermal growth factor (EGF) or phorbol esters (12‐ O ‐tetradecanoyl‐phorbol‐13‐acetate (TPA)). A stable Chinese hamster ovary (CHO)‐anx6 line overexpressing established examine function these cells, no increase Ras‐GTP levels, induced EGF...
Abstract Viral accessory proteins play critical roles in viral escape form host innate immune responses and inflammatory pathogenesis. Here we show that the SARS-CoV-2 protein, ORF9b, but not other (ORF3a, ORF3b, ORF6, ORF7, ORF8, ORF9c, ORF10), strongly activates inflammasome-dependent caspase-1 A549 lung carcinoma cells THP-1 monocyte-macrophage cells. Exposure to lipopolysaccharide (LPS) ATP additively enhanced activation of by suggesting ORF9b LPS follow parallel pathways inflammasome...