A5078583429- Reproductive Biology and Fertility
- Sperm and Testicular Function
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Research on Leishmaniasis Studies
- Galectins and Cancer Biology
- Renal and related cancers
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Testicular diseases and treatments
- Trypanosoma species research and implications
- MicroRNA in disease regulation
- RNA Research and Splicing
Consejo Superior de Investigaciones Científicas
2022
Centro de Biología Molecular Severo Ochoa
2021-2022
Universidad Autónoma de Madrid
2021-2022
Centro de Investigaciones Biológicas Margarita Salas
2017
In mammals, commitment and specification of germ cell lines involves complex programs that include sex differentiation, control proliferation, meiotic initiation. Regulation these processes is genetically controlled by fine-tuned mechanisms gene regulation in which microRNAs (miRNAs) are involved. We have characterized, small-RNA-seq bioinformatics analyses, the miRNA expression patterns male female mouse primordial cells (PGCs) gonadal somatic at embryonic stages E11.5, E12.5, E13.5....
Linker histones are highly abundant chromatin-associated proteins with well-established structural roles in chromatin and as general transcriptional repressors. In addition, it has been long proposed that histone H1 exerts context-specific effects on gene expression. Here, we identify a function of structure transcription using range genomic approaches. the absence H1, there is an increase non-coding RNAs, together reduced levels m6A modification leading to their accumulation causing...
Recently, an effective testis culture method using a gas-liquid interphase, capable of differentiate male germ cells from neonatal spermatogonia to spermatozoa has been developed. Nevertheless, this methodology needs deep analyses that allow future experimental approaches in basic, pathologic and/or reprotoxicologic studies. Because this, we characterized at cellular and molecular levels the entire vitro spermatogenic progression, order understand evaluate characteristics define process ex...
Abstract In Chagas disease (ChD) caused by Trypanosoma cruzi , new biomarkers to predict chronic cardiac pathology are urgently needed. Previous studies in chagasic patients with mild symptomatology showed that antibodies against the immunodominant R3 epitope of sCha, a fragment human basic helix‐loop‐helix transcription factor like 5, correlated pathology. To validate sCha as biomarker and understand origin anti‐sCha antibodies, we conducted multicenter study several cohorts severe...