A5088201957- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Computational and Text Analysis Methods
- MicroRNA in disease regulation
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Cancer-related Molecular Pathways
- Healthcare Systems and Public Health
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- Macrophage Migration Inhibitory Factor
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- Chronic Disease Management Strategies
- Machine Learning in Healthcare
- Colorectal Cancer Screening and Detection
- CAR-T cell therapy research
- Galectins and Cancer Biology
- Cell death mechanisms and regulation
- Cytomegalovirus and herpesvirus research
University of Birmingham
2010-2019
Institut des Sciences Biologiques
2015
The transcriptional regulator c-MYC is abnormally overexpressed in many human cancers. Evasion from apoptosis critical for cancer development, particularly c-MYC-driven We explored which anti-apoptotic BCL-2 family member (expressed under endogenous regulation) essential to sustain lymphoma growth reveal should be targeted therapy. Remarkably, inducible Cre-mediated deletion of even a single Mcl-1 allele substantially impaired the mouse lymphomas. Mutations p53 could diminish but not obviate...
ABSTRACT Epstein-Barr virus (EBV) has been shown to encode at least 40 microRNAs (miRNAs), an important class of molecules that negatively regulate the expression many genes through posttranscriptional mechanisms. Here, we have used real-time PCR assays quantify levels EBV-encoded BHRF1 and BART miRNAs in latently infected cells induced into lytic cycle. During latency, were seen only with detectable Cp- and/or Wp-initiated EBNA transcripts, while expressed all forms latent infection....
We have validated a flexible, high-throughput and relatively inexpensive RT-QPCR array platform for absolute quantification of Epstein–Barr virus transcripts in different latent lytic infection states. Several novel observations are reported. First, during normal B cells, Wp-initiated gene remain far more abundant following activation the Cp promoter than was hitherto suspected. Second, EBNA1 transcript levels remarkably low all forms latency, typically ranging from 1 to 10 per cell. EBNA3A,...
Evasion of immune T cell responses is crucial for viruses to establish persistence in the infected host. Immune evasion mechanisms Epstein-Barr virus (EBV) context MHC-I antigen presentation have been well studied. In contrast, viral interference with MHC-II less understood, not only EBV but also other persistent viruses. Here we show that encoded BZLF1 can interfere recognition by CD4+ effector cells. This impaired occurred absence a reduction expression surface MHC-II, correlated marked...
<sec> <title>BACKGROUND</title> Managing multiple long-term conditions (MLTC) is a complex healthcare domain. It presents both challenges and opportunities for artificial intelligence (AI) tools. Understanding practitioners’ (HCPs) experiences of MLTC management the factors influencing their attitudes towards using AI in clinical decision-making crucial successful implementation. </sec> <title>OBJECTIVE</title> We aimed to explore perspectives primary care HCPs on managing tools support...
While the association of Epstein–Barr virus (EBV) with Burkitt lymphoma (BL) has long been recognised, precise role in BL pathogenesis is not fully resolved. EBV can be lost spontaneously from some cell lines, and these EBV-loss cells reportedly have a survival disadvantage. Here we generated an extensive panel clones multiple backgrounds examined their phenotype comparing them to isogenic EBV-positive counterparts. We report that, while loss rare, it consistently associated enhanced...