A5086156437- Diabetes Treatment and Management
- Chronic Disease Management Strategies
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Medical Malpractice and Liability Issues
- Diabetes Management and Research
- COVID-19 and Mental Health
- Diabetic Foot Ulcer Assessment and Management
- Pressure Ulcer Prevention and Management
- Patient Safety and Medication Errors
- Wound Healing and Treatments
- Neuroendocrine Tumor Research Advances
- Pharmaceutical Practices and Patient Outcomes
- Healthcare cost, quality, practices
- COVID-19 and healthcare impacts
- Data-Driven Disease Surveillance
- Chronic Kidney Disease and Diabetes
- Health disparities and outcomes
- Primary Care and Health Outcomes
- Higher Education Learning Practices
- Dialysis and Renal Disease Management
- Global Cancer Incidence and Screening
University of Birmingham
2020-2024
University of Bristol
2022
Cardiff University
2016-2020
University of Chicago
2016-2019
Chicago Department of Public Health
2016-2017
Northwestern University
2017
San Francisco Department of Public Health
2017
National Patient Safety Foundation
2016-2017
Frederick S. Pardee RAND Graduate School
2017
University of Chicago Medical Center
2016
OBJECTIVE: Panic attacks are a common complication of affective disorder, although the etiologic relationship panic and symptoms has not been determined. Evidence from family study suggests that disorder may be related genetically to bipolar disorder. This used diagnostic data NIMH Bipolar Disorder Genetics Initiative assess in separate, larger set familiality combined with METHOD: First-degree relatives (N=966) probands I (N=192) schizoaffective type, (N=11) were included study. All...
Primary care lags behind secondary in the reporting of, and learning from, incidents that put patient safety at risk.In primary care, there is no universally agreed approach to classifying severity of harm arising from such patient-safety incidents.This lack an limits could lead prevention injury patients.In a review research on we identified 21 existing approaches classification severity.Using World Health Organization's (WHO's) International Classification for Patient Safety as reference,...
Introduction Coexisting multiple health conditions is common among older people, a population that increasing globally. The potential for polypharmacy, adverse events, drug interactions and development of additional complicates prescribing decisions these patients. Artificial intelligence (AI)-generated decision-making tools may help guide clinical in the context conditions, by determining which medication options best. This study aims to explore perceptions healthcare professionals (HCPs)...
<h3>PURPOSE</h3> A culture of blame and fear retribution are recognized barriers to reporting patient safety incidents. The extent attribution in incident reports, which may reflect the underlying health care systems, is unknown. This study set out explore nature family practice reports. <h3>METHODS</h3> We characterized a random sample reports from England Wales National Reporting Learning System. Reports were analyzed according prespecified classification systems describe type,...
To identify whether active use of nonsteroidal antiinflammatory drugs (NSAIDs) increases susceptibility to developing suspected or confirmed coronavirus disease 2019 (COVID-19) compared the other common analgesics.We performed a propensity score-matched cohort study with comparators, using large UK primary care data set. The consisted adult patients age ≥18 years osteoarthritis (OA) who were followed up from January 30 July 31, 2020. Patients prescribed an NSAID (excluding topical...
<sec> <title>BACKGROUND</title> Managing multiple long-term conditions (MLTC) is a complex healthcare domain. It presents both challenges and opportunities for artificial intelligence (AI) tools. Understanding practitioners’ (HCPs) experiences of MLTC management the factors influencing their attitudes towards using AI in clinical decision-making crucial successful implementation. </sec> <title>OBJECTIVE</title> We aimed to explore perspectives primary care HCPs on managing tools support...
Sodium-glucose co-transporter-2 (SGLT2) inhibitors are widely prescribed in people with type 2 diabetes. We aimed to investigate whether SGLT2 inhibitor prescription is associated COVID-19, when compared an active comparator. performed a propensity-score-matched cohort study comparators and negative control outcome large UK-based primary care dataset. Participants (n = 9948) comparator group dipeptidyl peptidase-4 (DPP-4) 14 917) were followed up from January 30 July 27, 2020. The was...
Diabetes has emerged as an important risk factor for mortality from COVID-19. Metformin, the most commonly prescribed glucose-lowering agent, been proposed to influence susceptibility and outcomes of COVID-19 via multiple mechanisms. We investigated whether, in patients with diabetes, metformin is associated its outcomes.We performed a propensity score-matched cohort study active comparators using large UK primary care dataset. Adults type 2 diabetes current prescription other agents (MF+)...
Diagnostic imaging, surgical care, and perioperative morbidity mortality have significantly improved for patients undergoing resections pancreatic adenocarcinoma. This study was undertaken to define the natural history patterns of recurrence resected cancer without neoadjuvant or adjuvant therapies using current standards care. Sixty-one underwent pancreatectomy therapy. Tumors were staged according American Joint Committee on Cancer (AJCC) classification system. CT scans obtained every 3...
Intensive glycemic control in type 2 diabetes (glycated hemoglobin [HbA1c] level <7%) is an established, cost-effective standard of care. However, guidelines recommend individualizing goals on the basis age, comorbidity, duration, and complications.To estimate cost-effectiveness individualized versus uniform intensive (HbA1c for U.S. population with diabetes.Patient-level Monte Carlo-based Markov model.National Health Nutrition Examination Survey 2011-2012.The approximately 17.3 million...
Background. Diabetes guidelines recommend individualizing glycemic goals (A1C) for older patients. The aim of this study was to assess a personalized Web-based decision support tool. Methods. We randomized physicians and their patients with type 2 diabetes (≥65 years age) tool or educational pamphlet (75:25 patients). Prior visit, intervention interacted the tool, which provided risk predictions elicited treatment preferences. Main outcomes included 1) patient-doctor communication, 2)...
Multimorbidity, characterised by the coexistence of multiple chronic conditions in an individual, is a rising public health concern. While much existing research has focused on cross-sectional patterns multimorbidity, there remains need to better understand longitudinal accumulation diseases. This includes examining associations between important sociodemographic characteristics and rate progression conditions.
Abstract Introduction Renin-angiotensin system (RAS) inhibitors have been postulated to influence susceptibility Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). This study investigated whether there is an association between their prescription and the incidence of COVID-19 all-cause mortality. Methods We conducted a propensity-score matched cohort comparing among patients with hypertension prescribed angiotensin-converting enzyme I (ACE) or angiotensin II type-1 receptor...
To compare the incident risk of RA in patients with type 2 diabetes mellitus (T2DM) and to explore role glycaemic control associated therapeutic use onset RA.This study was a retrospective cohort using derived from IQVIA Medical Research Data (IMRD-UK) database between 1995 2019. A total 224 551 newly diagnosed T2DM were matched 449 101 without followed up assess their RA. Further analyses investigated effect control, statin anti-diabetic drugs on relationship time-dependent Cox regression...
Introduction. To develop and validate the first real-world data-based type 2 diabetes progression model (RAPIDS) employing econometric techniques that can study comparative effects of complex dynamic patterns glucose-lowering drug use. Methods. The US Department Veterans Affairs (VA) electronic medical record claims databases were used to identify over 500,000 patients in 2003 with up 9-year follow-up. RAPIDS contains interdependent first-order Markov processes quarters for each micro-...
Abstract Introduction We report a pathfinder study of AI/knowledge engineering methods to rapidly formalise COVID‐19 guidelines into an executable model decision making and care pathways. The knowledge source for the was material published by BMJ Best Practice in March 2020. Methods PROforma guideline modelling language OpenClinical.net authoring publishing platform were used create data patients together with models rules, decisions plans that interpret patient give personalised advice....
BACKGROUND: Geographic variation in the use of prescription drugs, particularly those deemed harmful by FDA, may lead to patient exposure adverse drug events. One such is glucose-lowering rosiglitazone, for which FDA issued a safety alert on May 21, 2007, following publication meta-analysis that suggested 43% increase risk myocardial infarction with rosiglitazone. This was followed black box warning August 14, updated 3 months later. While large declines have been documented rosiglitazone...