Background The paradigm of bronchiectasis is shifting away from its exclusive characterization as a neutrophilic condition. Patients with and high eosinophil levels have been found to specific phenotype, but the clinical effect eosinopenia remains unclear. Method A retrospective, single-center, observational study was conducted at tertiary medical center. Adult patients under follow-up for January 2007 August 2020 were categorized by blood count (BEC) follows: (<100 cells/µL), normal...

Background: Nitric oxide (NO) plays a key role in various physiological processes. Inhaled NO (iNO) has been studied for treating acute respiratory distress syndrome (ARDS). During the COVID-19 pandemic, interest grew its potential patients with ARDS, studies showing improved oxygenation over 48 h. Methods: This is retrospective study of adult severe ARDS and refractory hypoxemia admitted to medical ICU requiring mechanical ventilation treated iNO. The effect on oxygenation, respiratory,...

Pulmonary alveolar proteinosis (PAP) presents a significant challenge due to its progressive and potentially fatal nature. Whole lung lavage (WLL) is key treatment for primary PAP with respiratory failure. Despite efficacy, the lack of standardised protocols has led diverse practice techniques across different institutions. Our study introduces novel approach, employing cardiopulmonary bypass (CPB) system infusing fluid, method not previously utilised. This paper will share our pioneering...

Adequate tissue sampling is fundamental for establishing a definitive diagnosis, assessing prognosis and tailoring therapy. Each of the methods obtaining (e.g., endoscopic, image guidance surgical biopsies) results in different diagnostic yield complication rate profile.Present feasibility, assess safety efficacy freehand transthoracic ultrasound-guided core-needle biopsies (USGNB) thoracic lesions performed by pulmonologist.A retrospective analysis study at Pulmonary Institute Rabin Medical...

Abstract Purpose To assess the impact of inhaled nitric oxide (iNO) on six-minute walk distance in patients with advanced interstitial lung disease Methods In a prospective, single-blinded, randomized, placebo-controlled trial, participants disease, underwent two separate tests: one iNO and other placebo. The primary outcome measured difference meters between distances covered tests. Secondary outcomes included oxygen saturation levels, distance-saturation product, Borg dyspnea score. A...

<title>Abstract</title> Hyperuricemia has been identified as a powerful predictor of World Health Organization (WHO) group 1 pulmonary hypertension (PH) (pulmonary arterial hypertension). However, its relationship with PH secondary to chronic lung diseases (WHO 3) remains unclear. Demographic, clinical, laboratory, function, and right heart catheterization data were retrospectively collected for 323 patients various severe undergoing evaluation transplantation at tertiary university medical...

Abstract Background Inhaled nitric oxide (iNO) selectively acts on the pulmonary vasculature of ventilated lung tissue by reducing vascular resistance and intrapulmonary shunt. This effect may reduce ventilation/perfusion mismatch decrease hypertension in patients with interstitial disease. Methods In a prospective, single-blinded, randomized, placebo-controlled trial, participants advanced disease, underwent two separate six-minute walk tests (6MWT): one iNO other placebo. The primary...

The prognostic significance of pretransplant N-terminal pro-brain (B)-type natriuretic peptide (NT-proBNP) level has not been investigated in lung transplant recipients. electronic files 173 patients with chronic disease who underwent transplantation 2018-2022 at a tertiary medical center were retrospectively reviewed. Right heart catheterization (RHC) and NT-proBNP determination performed preoperatively all cases. Pretransplant demographic, clinical, laboratory data compared between...

Abstract Idiopathic pulmonary fibrosis (IPF) is a diagnosis of exclusion, requiring that potential etiologies interstitial lung disease be ruled out. Antinuclear antibody (ANA) testing commonly performed in individuals with IPF, but the clinical significance ANA positivity remains uncertain. A retrospective search identified 161 patients diagnosed IPF between May 2010 and January 2021. Data on titers at time were available all cases. Mean age was 66.4 ± 9.6 years; 70.8% male. high (≥ 1:160)...

Abstract Background Right middle lobe (RML) syndrome is a recurrent or chronic obstruction of the RML causing atelectasis right due to mechanical and nonmechanical etiologies. The consequences untreated range from cough post‐obstructive pneumonia bronchiectasis. We report here our bronchoscopy experience in patients with syndrome. Methods conducted retrospective study adult who underwent for at Rabin Medical Center 2008 through 2022. Demographic data medical history, findings procedures,...

Broncho-biliary fistula (BBF) is an extremely rare but serious medical condition resulting from pathological communication between the biliary system and bronchial tree. Treatment options include both surgical non-surgical approaches. Several endobronchial techniques, such as spigot glue, can be used for this purpose. This report discusses a patient who developed broncho-biliary following liver biopsy. The BBF was diagnosed during bronchoscopy successfully treated with Amplatzer device. To...

We investigated the prognostic significance of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in lung transplant candidates, a retrospective single-center study. Data regarding various baseline characteristics and all-cause mortality were collected for 205 candidates placed on waitlist transplantation from November 2017 to December 2019. Associations NT-proBNP levels with analyzed. Results showed values correlated positively age, forced vital capacity, mean pulmonary artery pressure...

Abstract Background Patients with interstitial lung disease (ILD) are at high risk of severe COVID-19 infection. Additionally, their anti-inflammatory and antifibrotic treatment may cause immunosuppression. Nevertheless, ability to mount an adequate immune response messenger RNA SARS-CoV-2 vaccines was not evaluated. Therefore, we aimed evaluate the humoral after BNT162b2 vaccine among idiopathic pulmonary fibrosis (IPF) patients treated therapy non-IPF ILD therapy. Methods We conducted...

<b>Background:</b> The prognostic significance of amino-terminal pro-brain natriuretic peptide (NT-proBNP) in lung transplant candidates has not been investigated. <b>Methods:</b> study was designed as a retrospective single-center investigation. Data regarding various baseline characteristics and all-cause mortality were collected 172 placed waiting list during November 2017−August 2018. associations NT-proBNP levels with analyzed. <b>Results:</b> values correlated positively age, forced...

Abstract Background: Patients with interstitial lung disease (ILD) are at high risk of severe COVID-19 infection. Additionally, their anti-inflammatory and antifibrotic treatment may cause immunosuppression. Nevertheless, ability to mount an adequate immune response messenger RNA SARS-CoV-2 vaccines was not evaluated. We aimed evaluate the humoral after BNT162b2 vaccine among idiopathic pulmonary fibrosis (IPF) patients treated therapy non-IPF ILD therapy. Methods: conducted observational...