A5025538220- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Nuclear Structure and Function
- Metabolism and Genetic Disorders
- Histone Deacetylase Inhibitors Research
- Renal and related cancers
- Cerebrovascular and genetic disorders
- Hedgehog Signaling Pathway Studies
- Autoimmune and Inflammatory Disorders Research
- Adipose Tissue and Metabolism
- Caveolin-1 and cellular processes
- Advanced Breast Cancer Therapies
- Genetic Neurodegenerative Diseases
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Research and Splicing
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- Photosynthetic Processes and Mechanisms
- Hereditary Neurological Disorders
- Microtubule and mitosis dynamics
Osaka University
2018-2022
University of Cologne
2016-2018
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2016-2018
Kurume University
2016-2017
Institute of Cell Biology
2014
Kyushu University
2009-2014
Japan Science and Technology Agency
2009-2013
Maintenance of bone integrity is mediated by the balanced actions osteoblasts and osteoclasts. Because macroautophagy/autophagy regulates osteoblast mineralization, osteoclast differentiation, their secretion from cells, autophagy deficiency in or osteoclasts can disrupt this balance. However, it remains unclear whether upregulation becomes beneficial for suppression bone-associated diseases. In study, we found that genetic facilitated formation. We generated mice which was specifically...
Abstract The systemic decline in autophagic activity with age impairs homeostasis several tissues, leading to age-related diseases. A mechanistic understanding of adipocyte dysfunction could help prevent metabolic disorders, but the role autophagy aged adipocytes remains unclear. Here we show that, contrast other upregulate due a levels Rubicon, negative regulator autophagy. Rubicon knockout causes fat atrophy and hepatic lipid accumulation reductions expression adipogenic genes, which can...
Protrudin is a protein that contains Rab11-binding domain and FYVE (lipid-binding) functions to promote neurite formation through interaction with the GDP-bound form of Rab11. also short sequence motif designated FFAT (two phenylalanines in an acidic tract), which other proteins has been shown mediate binding vesicle-associated membrane protein-associated (VAP). We now show protrudin associates colocalizes VAP-A, isoform VAP expressed endoplasmic reticulum. Both between VAP-A as well...
Protrudin is a membrane protein that regulates polarized vesicular trafficking in neurons. The protrudin gene (ZFYVE27) mutated subset of individuals with hereditary spastic paraplegia (HSP), and therefore also referred to as (SPG) 33. We have now generated mice express transgene for dual epitope-tagged under control neuron-specific promoter, we subjected highly purified protrudin-containing complexes isolated from the brain these proteomics analysis identify proteins associate protrudin....
Mitochondrial morphology is dynamically regulated by fusion and fission. Several GTP ase proteins control fission, posttranslational modifications of these are important for the regulation. However, it has not been clarified how fission balanced. Here, we report molecular mechanism to regulate mitochondrial in mammalian cells. Ablation repression Drp1 or Mff, over‐expression MiD49 MiD51, results a reduction mitofusins (Mfn1 Mfn2) outer membrane long form OPA 1 (L‐ 1) inner membrane. RNA i‐...
<h3>Background</h3> Cell survival critically depends on the integrity of mitochondria, which play a pivotal role during apoptosis. Extensive mitochondrial damage promotes release pro-apoptotic factors from intermembrane space mitochondria. Released proteins include Smac/DIABLO and HTRA2/Omi, inhibit cytosolic E3 ubiquitin ligase XIAP other inhibitors apoptosis proteins. <h3>Aims</h3> Here we investigated cause extreme hypertonia at birth, alternating with hypotonia, subsequent appearance...
Protrudin is a membrane protein that regulates polarized vesicular transport. Now, we have identified novel isoform of protrudin (protrudin‐L) contains an additional seven amino acids between the FFAT motif and coiled‐coil domain compared with conventional (protrudin‐S) as result alternative splicing microexon (exon L). Protrudin‐L mRNA was found to be mostly restricted central nervous system in mice, whereas protrudin‐S detected all tissues examined. With use reporter minigene produces two...