A5074710386- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Optical Imaging and Spectroscopy Techniques
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Neural dynamics and brain function
- Cognitive Science and Mapping
- Advanced MRI Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Health and Well-being Studies
- Cognitive Abilities and Testing
- Cardiovascular Syncope and Autonomic Disorders
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Attention Deficit Hyperactivity Disorder
- Extracellular vesicles in disease
- Axon Guidance and Neuronal Signaling
- Spatial Neglect and Hemispheric Dysfunction
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
University of Florida
2019-2024
University of Florida Health
2020-2024
Children's National
2017-2019
Florida State University
2016
Tallahassee Orthopedic Clinic
2016
Aging is associated with disruptions in the resting-state functional architecture of brain. Previous studies have primarily focused on age-related declines default mode network (DMN) and its implications Alzheimer's disease. However, due to mixed findings, it unclear if changes connectivity are linked cognitive decline healthy older adults. In present study, we evaluated influence intra-network coherence for four higher-order networks a sensitive measure aging (i.e., NIH Toolbox Fluid...
BackgroundTranscranial direct current stimulation (tDCS) is widely investigated as a therapeutic tool to enhance cognitive function in older adults with and without neurodegenerative disease. Prior research demonstrates that electric delivery the brain can vary significantly across individuals. Quantification of this variability could enable person-specific optimization tDCS outcomes. This pilot study used machine learning MRI-derived field models predict working memory improvements proof...
Objective: The association between hippocampal volume and memory is continuing to be characterized in healthy older adults. Prior research suggests smaller adults associated with poorer episodic processing speed, as well working memory, verbal learning, executive functioning measured by the NIH Toolbox Fluid (FCC) Crystalized Cognition Composites (CCC). This study aimed replicate these findings, evaluate 1) asymmetry index cognition 2) independent contributions of left right a large sample...
Minimizing head motion during functional magnetic resonance imaging (fMRI) is important for maintaining the integrity of neuroimaging data. While there are a variety techniques to control motion, oftentimes, individuals with excessive in-scanner removed from analyses. Movement in scanner tends increase age; however, cognitive profile these "high-movers" older adults has yet be explored. This study aimed assess association between (i.e., number "invalid scans" flagged as outliers) and...
Abstract Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies integrated multimodal imaging simultaneously investigate relationships among structure, function, cognition. We aimed clarify how specifically DLPFC contribute memory healthy older adults. In total, 138 participants aged 65–88 underwent 3 T neuroimaging were divided into higher lower groups based on a median split of in-scanner n-back...
Frontal lobe structures decline faster than most other brain regions in older adults. Age-related change the frontal is associated with poorer executive function (e.g., working memory, switching/set-shifting, and inhibitory control). The effects presence of white matter hyperintensities (WMH) on normal aging relatively unknown. current study assessed relationships between region-specific WMH load cognitive performance healthy adults using three tasks from NIH Toolbox (NIHTB) Cognition...
This study examines the impact of transcranial direct current stimulation (tDCS) combined with cognitive training on neurotransmitter concentrations in prefrontal cortex.
Speed of processing is a cognitive domain that encompasses the speed at which an individual can perceive given stimulus, interpret information, and produce correct response. has been shown to decline more rapidly than other domains in aging population, suggesting this particularly vulnerable (Chee et al., 2009). However, heterogeneity neuropsychological measures used assess underpinning processing, diffuse pattern brain regions implicated. The current study aims investigate structural neural...
BackgroundWhite matter hyperintensities (WMH) are estimated to occur in greater than 63% of older adults over the age 60 years. WMH identified T2-weighted FLAIR images can be combined with T1-weighted enhance individualized current flow models by accounting for presence and its effects on delivered tES aging brain.MethodsIndividualized head were derived from 130 healthy (mean = 71 years). Lesions segmented acquisition added models. Current densities computed brain compared between without...
Abstract Declines in processing speed performance occur aging and are a critical marker of functional independence older adults. Studies suggest that Useful Field View (UFOV) training may ameliorate cognitive decline. Despite its efficacy, little is known about the neural correlates this task. Within current study, 233 healthy adults completed UFOV-based task while undergoing magnetic resonance imaging (fMRI). During “stimulus” portion task, participants must identify target center screen...
Previous studies using the King-Devick (K-D) suggest increased reading times following concussion when compared to baseline testing. These have not examined effects of exercise in a sample non-concussed high school student athletes. PURPOSE: To examine on K-D test at preseason, pre-practice and mid-practice time points, student-athletes as part an on-going project. METHODS: Twenty-one athletes (15.7 ± 1.5 years; 8 Football, 7 Volleyball, 6 Cheer) completed: error-free preseason (BL); prior...
Abstract Objective Executive functioning is a cognitive domain that typically declines with normal aging. Age-related disrupted connectivity in cingulo-opercular (CON) and frontoparietal control (FPCN) resting-state networks associated worse performance across various executive tasks. This study examines the relationships between CON FPCN older adults three subdomains: working memory, inhibition, set-shifting. Methods 274 healthy (age M = 71.7, SD 5.1; 87% Caucasian) from clinical trial at...
Objective: The National Institutes of Health-Toolbox cognition battery (NIH-TCB) is widely used in cognitive aging studies and includes measures domains evaluated for dimensional structure psychometric properties prior research. present study addresses a current literature gap by demonstrating how NIH-TCB integrates into traditional clinical neuropsychological measures. along with conventional tests assessed healthy older adults. Participants Methods: Baseline data were obtained from 327...