A5090330010- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Electrochemical Analysis and Applications
- Medicinal Plants and Neuroprotection
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Synthesis and biological activity
- Advanced Chemical Sensor Technologies
- Antioxidant Activity and Oxidative Stress
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Cholinesterase and Neurodegenerative Diseases
- Chemical synthesis and pharmacological studies
- bioluminescence and chemiluminescence research
- Lipid Membrane Structure and Behavior
- Youth Substance Use and School Attendance
- Neuroscience of respiration and sleep
- Synthesis and Characterization of Heterocyclic Compounds
- Photoreceptor and optogenetics research
- Electrochemical sensors and biosensors
- Neural dynamics and brain function
- GABA and Rice Research
Universidad de Guadalajara
2011-2022
Centro de Investigación y Proyectos en Ambiente y Desarrollo
2022
Universidad Nacional Autónoma de México
2018
The pilocarpine model of temporal lobe epilepsy (TLE) is a useful tool that used to investigate the mechanisms underlying generation and maintenance seizures. Although this has been modified significantly reduce mortality promote appearance spontaneous recurrent seizures, date, no detailed evaluation performed behavioral parameters in TLE induced by intracerebroventricular administration; therefore, was goal present study. A single dose hydrochloride (2.4 mg total volume 2 µl) injected into...
Glutamate has been measured using different methods to determine its role under normal and pathological conditions. Although microdialysis coupled with HPLC is the preferred method study glutamate, this technique exhibits poor temporal resolution time consuming. The concentration of glutamate in dialysis samples can be via oxidase Amplex Red method. A new device designed constructed rapidly deposit onto a polycarbonate plate at Cartesian coordinates (every five seconds). were added an...
Status epilepticus (SE) can result in an overproduction of hydrogen peroxide (H2O2), which contributes to oxidative stress and brain injury during different phases epileptogenesis seizures. In this study, we measured the extracellular H2O2 concentration rat hippocampus a temporal lobe epilepsy model. A new fluorescent technique for measuring vivo simultaneously with electroencephalography recording was tested. The method consists mixing microdialysate enzymatic reactor produce compound....
Abstract Glutamate measurement in microdialysis samples has primarily been determined using HPLC methods, and several attempts have made to establish a relationship between this neurotransmitter EEG activity during altered brain function, such as epilepsy. However, classic methods lack high temporal resolution. In study, new alternative is proposed improve the time resolution thus obtain better understanding of dynamics Glu its with epileptiform activity. A setup was designed measure online...
Background During status epilepticus, severe seizures can occur, generating recurrent cycles of excitotoxicity and oxidative stress that cause neuronal damage cell death. The administration agents with antioxidant properties represents a therapeutic alternative aimed at reducing the severity epilepticus mitigating neurobiological consequences precede them. Objective objective this work was to evaluate antiseizure effect antioxidants allopurinol (ALL) ellagic acid during induced by...
γ-Aminobutyric acid (GABA) is a well-known neurotransmitter that regulates inhibitory neurotransmission in the mammalian central nervous system and participates several processes outside brain. A reliable quantification method needed to determine its role different physiological pathological conditions. However, GABA measurements have challenges because neither fluorescent nor electroactive, it difficult detect using enzymatic reactions no oxidases or dehydrogenases been identified. Several...
Epilepsy is a common neurological disorder that affects around 70 million people in the world, which represents approximately 1%of world population. Seizures are transitory episodes produced by excessive neuronal discharges. They characterized bytransient behavioral changes caused abnormal and synchronization brain. These canbe triggered genetic or acquired factors alter normal brain function such as autoimmune diseases, mutations,encephalopathies, head trauma, cerebrovascular accidents,...
The inflammasome is assembled in response to a wide range of patterns associated with pathogens or damage molecules inpresence brain injury, they are multiproteic complexes that comprise sensor, an adapter protein and zymogenic enzyme thatactivates caspase-1 for secretion mature proteins IL-1β IL-18 trigger pyroptosis (neuroinflammation-induced celldeath) which involved the onset development several pathophysiological events. Until now, four inflammasomes havebeen described recruit...