Albumin is an indicator of nutritional status and has been investigated as a predictor cancer survival perioperative outcomes. This study the prognostic value preoperative serum albumin in surgical patients with head neck (HNC).Retrospective cohort study.A chart review was performed who underwent HNC resection over 6-year period at single institution. Statistical analyses including Cox proportional hazards models, Pearson's correlation, logistic regression were used to identify relationships...

Abstract Objective: To provide a framework for the management of scalp and skull defects. Design: Retrospective chart review. Setting: Two tertiary care hospitals. Patients/Intervention: Fifty‐six consecutive patients who underwent reconstruction and/or defects with free flaps, rotational skin/fascia skin grafts, implants. Defects closed primarily those lateral temporal bone base were excluded. Results: Sixty‐two reconstructions performed. Treatment cancers intracranial tumors necessitated...

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have poor efficacy in head and neck squamous carcinoma cells (HNSCC). Because the IGF-1 (IGF1R) generates potent prosurvival signals has been implicated therapeutic resistance, its ability to induce resistance EGFR-TKIs was studied vitro. Five HNSCC cell lines showed reduced sensitivity EGFR-TKI gefitinib when IGF1R activated. In SCC-25 Cal27 cells, inhibited basal EGF-stimulated EGFR, extracellular signal-regulated...

The cullin RING E3 ubiquitin ligase 4 (CRL4) with its substrate receptor CDT2 (CRL4-CDT2) is emerging as a critical regulator of DNA replication through targeting CDT1, SET8, and p21 for ubiquitin-dependent proteolysis. aberrant increased stability these proteins in cells inactivated CRL4-CDT2 results rereplication, which deleterious to due the accumulation intermediates stalled forks. Here, we demonstrate that overexpressed head neck squamous cell carcinoma (HNSCC), depletion by siRNA...

Objectives/Hypothesis To determine whether blood transfusions are associated with adverse outcomes in patients head and neck cancer (HNC) undergoing microvascular free tissue transfer. Study Design Retrospective cohort study. Methods The records of all who underwent flaps for reconstruction after HNC resection from July 2007 through February 2013 at a single institution were reviewed. Rates overall survival (OS), recurrence (RFS), postoperative wound infection determined. Statistical...

Background Sinonasal anatomic variants have been postulated as a risk factor for sinus disease. Therefore, study was conducted to examine the correlation of disease septal deviation, concha bullosa, and infraorbital ethmoid cells. Methods Two hundred fifty consecutive orbital computed tomography scans were examined at University Virginia over 2-year period. Coronal, sagittal, axial views presence size bullosa Septal deviations measured by examining width nasal cavity level maxillary ostium....

Extubation (cessation of ventilatory support) is often delayed in free flap patients to protect the microvascular anastomosis, presumably by reducing emergence-related agitation. We sought determine if immediate extubation operating room (OR) would improve postoperative course compared intensive care unit (ICU).Retrospective chart review.Medical records all undergoing tissue transfer for head and neck reconstruction between January 2009 July 2010 were reviewed (n = 52). Patients extubated...

Even when technology allows rural cancer survivors to connect with supportive care providers from a distance, uptake of psychosocial referrals is low. Fewer than one-third participants in telemedicine intervention for identifying high distress and connecting them accepted referral.The purpose this research was examine the reasons which did not accept referral.We utilized qualitative design address purpose. We interviewed who had been offered referral. Semistructured interviews were conducted...

Abstract BACKGROUND: Patients with oropharyngeal squamous cell carcinoma (OPSCC) treated intensity‐modulated radiotherapy (IMRT) were stratified by p16 status, neck dissection, and chemotherapy to correlate these factors outcomes. METHODS: A total of 112 patients OPSCC IMRT from 2002 2008 retrospectively analyzed. All received RT 66‐70 Gray. Forty‐five the tumors positive (p16+), 27 negative (p16−), 41 had unknown status. Sixty‐two postradiation dissections. Nine p16− 28 p16+ chemotherapy....

Objectives/Hypothesis To compare the effectiveness of massed versus interval training when teaching otolaryngology residents microvascular suturing on a validated microsurgical model. Study Design Otolaryngology were placed into (n = 7) or groups. The group performed three separate 30‐minute practice sessions separated by at least 1 week, and single 90‐minute session. Both groups viewed video demonstration recorded pretest prior to first A post‐test was administered following last Methods At...

Bioluminescence imaging (BLI) is a relatively new noninvasive technology used for quantitative assessment of tumor growth and therapeutic effect in living animal models. BLI involves the generation light by luciferase-expressing cells following administration substrate luciferin presence oxygen ATP. In present study, effects hypoxia, hypoperfusion, pH on signal (BLS) intensity were evaluated vitro using cultured vivo xenograft model nude mice. The BLS was significantly reduced acute chronic...

To investigate the prognostic significance of p16 in patients with hypopharyngeal squamous cell carcinoma (HPSCC) and to evaluate relationship between human papillomavirus (HPV). Unlike oropharyngeal SCC (OPSCC), HPSCC its association HPV is unclear.Retrospective medical chart review.University tertiary referral center.A total 27 treated definitive radiation therapy 2002 2011 whose tissue was available for immunohistochemical analysis.Twenty-two were chemoradiation, 5 alone. All tumor biopsy...

Cyclin D1 and FADD (Fas-associated protein with death domain) regulate the cell cycle apoptosis, respectively, are located on chromosome 11q13, which is frequently amplified in head neck squamous carcinoma (HNSCC). This study evaluates these proteins as predictors of clinical outcomes for HNSCC.Historical cohort study.Academic tertiary care center.Two hundred twenty-two patients upper aerodigestive HNSCC.Patients tumors that were strongly positive cyclin had reduced overall (OS; P = .003 <...

The epidermal growth factor receptor (EGFR) is highly expressed in a variety of solid tumors including oral cavity squamous cell carcinoma (OSCC) and has been implicated the resistance these to cisplatin. This study was performed determine if EGFR tyrosine kinase inhibitor gefitinib could enhance cytotoxic effect cisplatin on OSCC cells vitro. expression phosphorylation its downstream signaling ERK, AKT pathway were detected by Western blotting. Cell proliferation survival determined...

<h3>Importance</h3> The prognostic significance of p16 in squamous cell carcinoma (SCC) the hypopharynx (HP) and nasopharynx (NP) relationship between human papillomavirus (HPV) is unclear. <h3>Objectives</h3> To evaluate pharyngeal subsites (oropharynx [OP], HP, NP) assess HPV HP NP. <h3>Design, Setting, Participants</h3> Retrospective medical record review 172 patients with SCC pharynx treated definitive radiation therapy from 2002 to 2013 at a university tertiary referral center, tissue...

To determine if suprafascial harvest of the radial forearm free flap improves postoperative donor site outcomes compared to subfascial harvest.Retrospective chart review.Forty-six patients underwent reconstruction a head and neck defect with (RFFF). Subfascial RFFF was performed in 25 (53%) 22 (47%) patients. All sites were covered split thickness skin graft bolster that remained place for 6 days. Postoperative tendon exposure at occurred 5 (20%) group 0 (0%) ( P = .05; Fisher's exact test)....

Signaling by the insulin-like growth factor (IGF)-1 receptor (IGF-1R) has been implicated in promotion and aggressiveness of breast, prostate, colorectal, lung cancers. The IGF binding proteins (IGFBPs) represent a class natural antagonists that bind to sequester IGF-1/2 from IGF-1R, making them attractive candidates as therapeutics for cancer prevention control. Recombinant human IGFBP-2 significantly attenuated IGF-1-stimulated MCF-7 cell proliferation with coaddition 20 or 100 nM (50 80%...

To identify factors that predict complete response of cervical nodal disease to radiation therapy (RT) in patients with oropharyngeal squamous cell carcinoma (OP-SCCA).Histologic analysis prospectively collected specimens and retrospective medical chart review.Tertiary referral center.Sixty-nine OP-SCCA treated from January 1, 2002, through June 2008.Definitive RT, or without chemotherapy neck dissection (ND).Presence a viable tumor post-RT ND specimen.Tissue 69 primarily chemotherapy, were...