A5062552011- Genomics and Chromatin Dynamics
- Plant Reproductive Biology
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Plant Molecular Biology Research
- RNA Research and Splicing
- Plant tissue culture and regeneration
- RNA modifications and cancer
New York University
2019-2022
The Origin Recognition Complex (ORC) is essential for replication, heterochromatin formation, telomere maintenance and genome stability in eukaryotes. Here we present the structure of yeast Orc1 BAH domain bound to nucleosome core particle. Our data reveal that Orc1, unlike its close homolog Sir3 involved gene silencing, does not appear discriminate between acetylated non-acetylated lysine 16, modification states histone H4 tail specify open closed chromatin respectively. We elucidate...
Essential molecules are embedded within the millenary crop Tropaeolum tuberosum (mashua); these compounds critical for Andean people’s traditional diet and extensively utilized by pharmaceutical industry in Peru. In region, conventional cropping techniques generate microtubers susceptible to a viral infection, which substantially endangers mashua’s production. Therefore, we developed an innovative vitro technique condition enhancing agriculture process micro tubers The temporary immersion...
Abstract Crossover recombination supports meiotic chromosome inheritance and fertility by establishing chiasmata between homologous chromosomes prior to the first division. In addition physical exchange of DNA mediated recombination, chiasma formation also involves restructuring underlying axis. Here, we identify condensin as an important regulator axis remodeling in S. cerevisiae . Condensin is recruited near sites crossover designation pro-crossover factors but largely dispensable for...