A5030628065- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
New York University
2019-2021
Cross-talk between histone modifications Histone play pivotal roles within the intricate protein networks that underlie transcription and gene silencing in eukaryotic genomes. The enzymes deposit them undergo spatiotemporal fine-tuning of their catalytic activity; one example is trans-histone cross-talk, which modification activates an enzyme responsible for another modification. Valencia-Sánchez et al. show H4 lysine 16 acetylation (H4K16ac), a hallmark decondensed, transcriptionally...
The Origin Recognition Complex (ORC) is essential for replication, heterochromatin formation, telomere maintenance and genome stability in eukaryotes. Here we present the structure of yeast Orc1 BAH domain bound to nucleosome core particle. Our data reveal that Orc1, unlike its close homolog Sir3 involved gene silencing, does not appear discriminate between acetylated non-acetylated lysine 16, modification states histone H4 tail specify open closed chromatin respectively. We elucidate...