A5103046097- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Cavitation Phenomena
- Electrospun Nanofibers in Biomedical Applications
- Ultrasound Imaging and Elastography
- 3D Printing in Biomedical Research
- Microfluidic and Bio-sensing Technologies
- Tendon Structure and Treatment
- Spaceflight effects on biology
- Inhalation and Respiratory Drug Delivery
- Aerosol Filtration and Electrostatic Precipitation
- Thermoregulation and physiological responses
- Angiogenesis and VEGF in Cancer
- Innovative Microfluidic and Catalytic Techniques Innovation
- Cellular Mechanics and Interactions
- Lattice Boltzmann Simulation Studies
- Fluid Dynamics and Heat Transfer
- Particle Dynamics in Fluid Flows
- Cardiovascular and Diving-Related Complications
- Combustion and flame dynamics
- Aerodynamics and Acoustics in Jet Flows
- Fluid Dynamics and Mixing
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Icing and De-icing Technologies
University of Michigan–Ann Arbor
2019-2024
George Washington University
2018-2024
Ann Arbor Center for Independent Living
2020
Phase-shift droplets are a highly adaptable platform for biomedical applications of ultrasound. The spatiotemporal response phase-shift to focused ultrasound above certain pressure threshold, termed acoustic droplet vaporization (ADV), is influenced by intrinsic features (e.g., bulk boiling point) and extrinsic factors driving frequency surrounding media). A deep understanding ADV dynamics critical ensure the robustness repeatability an ADV-assisted application. Here, we integrated...
Phase shift liquid perfluorocarbon (PFC) droplets vaporizable by ultrasound into echogenic microbubble above a threshold pressure, termed acoustic droplet vaporization (ADV), are used for therapeutic and diagnostic applications. This study systematically investigated the effect of excitation frequency (2.25, 10, 15 MHz) on ADV inertial cavitation (IC) thresholds lipid-coated PFC three different cores—perfluoropentane (PFP), perfluorohexane (PFH), perfluorooctyl bromide (PFOB)—and two...
Acoustically-responsive scaffolds (ARSs), which are fibrin hydrogels containing monodispersed perfluorocarbon (PFC) emulsions, respond to ultrasound in an on-demand, spatiotemporally-controlled manner via a mechanism termed acoustic droplet vaporization (ADV). Previously, ADV has been used control the release of bioactive payloads from ARSs stimulate regenerative processes. In this study, we classical nucleation theory (CNT) predict pressure emulsions different PFC cores as well...
Phase shift droplets vaporizable by acoustic stimulation offer the advantages of producing microbubbles as contrast agents in situ well higher stability and possibility achieving smaller sizes. Here, droplet vaporization (ADV) threshold a suspension with perfluoropentane (PFP) core (diameter 400-3000 nm) is acoustically measured function excitation frequency tubeless setup at room temperature. The changes scattered responses-fundamental, sub-, second harmonic-are investigated, quantitative...
Acoustic droplet vaporization (ADV) is the phase-transitioning of perfluorocarbon emulsions, termed phase-shift into bubbles using focused ultrasound. ADV has been utilized in many biomedical applications. For localized drug release, emulsions with a bioactive payload can be incorporated within hydrogel to yield an acoustically-responsive scaffold (ARS). The dynamics and associated release hydrogels are not well understood. Additionally, used ARSs often contain high molecular weight...
An ultrasound standing wave field (SWF) has been utilized in many biomedical applications. Here, we demonstrate how a SWF can enhance drug release using acoustic droplet vaporization (ADV) an acoustically-responsive scaffold (ARS). ARSs are composite fibrin hydrogels containing payload-carrying, monodispersed perfluorocarbon (PFC) emulsions and have used to stimulate regenerative processes such as angiogenesis. Elevated amplitudes the significantly enhanced payload from dextran-loaded...
Acoustic droplet vaporization (ADV) of phase shift emulsion (green) generates different bubble morphologies, and spatiotemporally tunes the micromechanics fibrin gels (red).
Phase-shift droplets provide a flexible and dynamic platform for therapeutic diagnostic applications of ultrasound. The spatiotemporal response phase-shift to focused ultrasound, via the mechanism termed acoustic droplet vaporization (ADV), can generate range bioeffects. Although ADV has been used widely in theranostic applications, ADV-induced bioeffects are understudied. Here, we integrated ultra-high-speed microscopy, confocal ultrasound real-time visualization mechanics sonoporation...
Cancer cells continually sense and respond to mechanical cues from the extracellular matrix (ECM). Interaction with ECM can alter intracellular signaling cascades, leading changes in processes that promote cancer cell growth, migration, survival. The present study used a recently developed composite hydrogel composed of fibrin phase-shift emulsion, termed an acoustically responsive scaffold (ARS), investigate effects local properties on breast signaling. Treatment ARSs focused ultrasound...
Acoustic droplet vaporization (ADV) offers a dynamic approach for generating bubbles on demand, presenting new possibilities in biomedical applications. Although ADV has been investigated various applications, its potential tissue characterization remains unexplored. Here, we the effects of surrounding media radial dynamics and acoustic emissions using theoretical experimental methodologies. For studies, bubble were combined with Kelvin-Voight material constitutive model, accounting...
Perfluorocarbon (PFC) droplets represent a novel class of phase-shift contrast agent with promise in applications biomedical and bioengineering fields. PFC undergo fast liquid-gas transition upon exposure to acoustic or optical triggering, offering potential adaptable versatile tool as diagnostics imaging localized drug delivery vehicles therapeutics systems. In this paper, we utilize advanced techniques investigate ultra-high-speed inertial dynamics rectified quasi-static (low-speed)...
Within the Department of Radiology at University Michigan, we have integrated mechanics, material science, and biomedical acoustics to develop ultrasound-assisted therapies diagnostic techniques. What is our approach? Using ultrasound-responsive droplets. These droplets phase-transition from liquid gas bubbles when exposed ultrasound, a process termed acoustic droplet vaporization (ADV). We harness this transformation for wide array applications, such as delivering therapeutic payloads,...
Shell-stabilized, phase-shift droplets of a perfluorocarbon liquid have been investigated for wide range applications. The shell plays key role in maintaining droplet stability and impacting the acoustic responses generated bubbles via vaporization (ADV). While behavior under ultrasound exposure is well-studied with contrast microbubbles, it not fully explored during post ADV. By integrating ultra-high-speed microscopy time-lapse confocal imaging, we radial dynamics ADV growth rate post-ADV...
Microporosity in hydrogels is critical for directing tissue formation and function. We have developed a fibrin-based smart hydrogel, termed an acoustically responsive scaffold (ARS), which responds to focused ultrasound spatiotemporally-controlled, user defined manner. ARSs are highly flexible platforms due the inclusion of phase-shift emulsions their tunable response through mechanism acoustic droplet vaporization (ADV). Here, we demonstrated that ADV enabled consistent generation...