A5051566689- Renal Transplantation Outcomes and Treatments
- Acute Lymphoblastic Leukemia research
- Organ Donation and Transplantation
- Pharmacological Effects and Toxicity Studies
- Cytomegalovirus and herpesvirus research
- Pregnancy and Medication Impact
- Liver Diseases and Immunity
- Organ Transplantation Techniques and Outcomes
- Pericarditis and Cardiac Tamponade
- Biochemical and Molecular Research
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
- Male Reproductive Health Studies
- Prenatal Screening and Diagnostics
- Toxoplasma gondii Research Studies
- Viral-associated cancers and disorders
- Cystic Fibrosis Research Advances
- Science and Education Research
- Cardiac tumors and thrombi
- Genetic and Kidney Cyst Diseases
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- COVID-19 and healthcare impacts
- Vascular Tumors and Angiosarcomas
- Trypanosoma species research and implications
Hospital Alemão Oswaldo Cruz
2017-2025
Hospital São Paulo
1977-2024
Faculdades Oswaldo Cruz
2020
Universidade de São Paulo
1987-2008
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
1981-2008
Universidade Brasil
1987
The immunosuppressive efficacy of azathioprine is related to its rapid metabolism in vivo 6-mercaptopurine (6MP), with subsequent conversion thioguanine nucleotides by an anabolic route involving hypoxanthine-guanine phosphoribosyltransferase. Two alternative catabolic routes exist: oxidation 6-thiouric acid via xanthine oxidase and methylation 6-methylmercaptopurine the enzyme thiopurine methyltransferase (TPMT). Catabolism either would restrict formation active metabolites.We analyzed TPMT...
Hepatotoxicity results in the withdrawal of thiopurines drugs, azathioprine (AZA) and mercaptopurine (MP), up to 10% patients with inflammatory bowel disease. Our group previously demonstrated that allopurinol AZA/ciclosporin/steroid 'triple therapy' improved renal graft survival.To confirm hypothesis may alleviate thiopurine hepatotoxicity by similar mechanisms as proposed our study.Unselected acute were offered co-therapy low-dose AZA or MP. The starting AZA/MP dose was determined...
Apresentamos o relato de caso um paciente diagnosticado com eritrocitose pós-transplante renal, cuja ocorrência deve ser conhecida para que possa diagnosticada forma acurada e corretamente tratada, preservando os pacientes consequências relacionadas à hiperviscosidade sanguínea. A renal apresenta diversos fatores risco, podendo assintomática ou manifestar-se típica. Sua patogênese é multifatorial. O diagnóstico realizado no contexto clínico apropriado, devendo necessariamente descartadas...
We present the case report of a patient diagnosed with erythrocytosis after kidney transplantation, occurrence which must be known so that it can accurately and correctly treated, preserving patients from consequences related to blood hyperviscosity. It has several risk factors asymptomatic or manifest in typical form. The pathogenesis transplantation is multifactorial. diagnosis made appropriate clinical context, other possible causes necessarily ruled out, some are potentially serious,...
This study compared the use of static cold storage versus continuous hypothermic machine perfusion in a cohort kidney transplant recipients at high risk for delayed graft function (DGF).In this national, multicenter, and controlled trial, 80 pairs kidneys recovered from brain-dead deceased donors were randomized to or perfusion, transplanted, followed up 12 months. The primary endpoint was incidence DGF. Secondary endpoints included duration DGF, hospital stay, nonfunction, estimated...
COVID-19 is a severe disease that has reached pandemic status. To the best of our knowledge, we describe first case and cytomegalovirus (CMV) co-infection in critically ill patient. We discuss challenge establishing diagnosis as well management tissue-invasive gastrointestinal CMV infection (TI-GI CMV) simulating vascular involvement intestinal obstruction
Introduction: The kidney may be affected by coronavirus (COVID-19) in the setting of acute injury (AKI). Data about AKI intensive care unit (ICU) patients Latin America are scarce. We aimed to evaluate risk AKI, dialysis (HD), and death ICU COVID-19 a Brazilian center. Methods: Analysis from medical records Results: A total 95 were analyzed. There was male predominance (64.2%), median age: 64.9 years, previous history hypertension diabetes 51.6 27.4%, respectively. diagnosed 54 (56.8%)...
3 patients with renal transplantation who developed polycythemia presented normalization of the hemoglobin levels immediately after nephrectomy native kidneys. This observation induced authors to study role kidneys in genesis recipients allografts. Comparison was made among 32 submitted transplantation, maintenance (group I) and 31 under same conditions, but without II). Both groups were comparable according age, sex, rejection crisis incidence immunosuppressive therapy. It observed that...
A catabolic route for azathioprine involving methylation by thiopurine methyltransferase has been directly implicated in the drug's immunosuppressive efficacy. Since ethnic differences activity have reported a study of Lapps, this compared distribution erythrocyte lysates from 134 healthy, randomly selected subjects living Brazil, comprising 39 blacks (i.e. Afro-Brazilians), 33 white subjects, 30 mixed-race and 32 Brazilian-residing Japanese subjects. The results demonstrated bimodality...
Em sete pacientes submetidos a transplante de rim e imonodeprimidos reconheceram os Autores ocorrência doença Chagas, em fase aguda. Tais eventos permitiram verificações sem dúvida expressivas e, entre elas, afigurou-se conveniente salientar as seguintes: presença febre como manifestação proeminente; valor elucidativo da pesquisa do Trypanosoma cruzi no "creme" leucocitário etapa realização diagnóstico diferencial, quando escassos elementos orientadores; utilidade evidenciação, por...
Abstract Background Cyst infection is a prevalent complication in autosomal dominant polycystic kidney disease (ADPKD) patients, however therapeutic and diagnostic approaches towards this condition remain unclear. The confirmation of likely episode cyst by isolating the pathogenic microorganism clinical scenario possible only minority cases. available antimicrobial treatment guidelines, therefore, might not be appropriate to some patients. Case presentation We describe two unique cases...
Purpose: The purpose of this study is to evaluate the safety and efficacy mechanical thrombectomy with Indigo System in treatment thrombosed arteriovenous fistulas grafts. Methods: A retrospective search endovascular procedures performed from November 2018 June 2020 was conducted. Inclusion criteria were: acute fistula or graft thrombosis that underwent System. following information collected each case: sex, age, modality, location, outcomes. Endpoints evaluated technical clinical success...
Primary Effusion Lymphoma is an extremely rare and aggressive subtype of B-cell lymphoma, accounting for only <1% all cases this neoplasm. It has a unique clinical presentation because it predilection appearing in body cavities, such as the pleural space, pericardium peritoneum. mainly affects immunocompromised individuals may also affect Mediterranean region areas endemic human herpesvirus 8 (HHV-8). Herein, we report case 83-year-old immunocompetent male complaining coughing, fever...
Os nucleotídeos de tioguanina (6-TGN), metabólitos ativos da azatioprina (AZA) e 6-mercaptopurina (6-MP), atuam como antagonistas das purinas, inibindo as sínteses DNA, RNA a protéica, induzindo à citotoxicidade/imunossupressão. A enzima geneticamente determinada, tiopurina metiltransferase (TPMT), está envolvida no metabolismo desses agentes e, hipoteticamente, determina resposta clínica às tiopurinas. baixa atividade dessa diminui metilação tiopurinas, resultando em potencial sobredose,...
Abstract Background McArdle disease is a myopathy caused by mutations in PYGM gene that characterized reduced or absent activity of myophosphorylase. Reports patients with concomitant and diabetes are scarce. We report case patient late diagnosis we postulate symptoms may be related to hypoinsulinemia. Case presentation This describes the evolution an elderly diabetic confirmed McArdle’s based on absence myophosphorylase analysis muscle biopsy, homozygous mutation gene. The variant – Chr11:...
Mycophenolate rapidly substituted azathioprine (AZA) in transplant immunosuppression regimens since the 1990s, when early clinical trials indicated better outcomes, although opposite results were also observed. However, none of these used well-established optimization methods for AZA dosing, namely, thiopurine methyltransferase pharmacogenetics combined with monitoring metabolites 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP). Resistance to optimize therapy remains...
No AccessJournal of Urology1 Feb 1994Renal Transplantation Using External Continent Urinary Diversion Antonio Marmo Lucon, Emil Sabbaga, Luis E. Ianhez, Pedro R. Chocair, José O.M. Pestana, and Sami Arap LuconAntonio Lucon More articles by this author , SabbagaEmil Sabbaga IanhezLuis Ianhez ChocairPedro Chocair PestanaJosé Pestana ArapSami View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)34963-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...