A5012838211- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Neurological Complications and Syndromes
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Pediatric Urology and Nephrology Studies
- Polyomavirus and related diseases
- Renal and Vascular Pathologies
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Urological Disorders and Treatments
- Sexual function and dysfunction studies
- Pharmacological Effects and Toxicity Studies
- Blood groups and transfusion
- Urinary Tract Infections Management
- Sexuality, Behavior, and Technology
- Ureteral procedures and complications
- Urinary Bladder and Prostate Research
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- Hormonal and reproductive studies
- Health, Nursing, Elderly Care
- Maternal and Neonatal Healthcare
- Adenosine and Purinergic Signaling
- Male Reproductive Health Studies
Hospital do Rim e Hipertensão
2015-2023
Universidade Federal de São Paulo
2009-2023
E Ink (South Korea)
2016
Associação Fundo de Incentivo à Pesquisa
2016
Pfizer (United Kingdom)
2016
Roche (Switzerland)
2016
Bristol-Myers Squibb (Germany)
2016
Novartis (Switzerland)
2016
Pediatric Nephrology of Alabama
2016
This study compared the incidence of CMV infection/disease in de novo kidney transplant recipients receiving everolimus or mycophenolate and no pharmacological prophylaxis. We randomized 288 patients to receive a single 3 mg/kg dose antithymocyte globulin, tacrolimus, everolimus, prednisone (r-ATG/EVR, n = 85); basiliximab, (BAS/EVR, 102); mycophenolate, (BAS/MPS, 101). The primary end-point was first intention-to-treat population at 12 months. Patients treated with r-ATG/EVR showed 90%...
It is unclear if there an association between the duration of delayed graft function (DGF) and kidney transplant (KT) outcomes. This study investigated impact prolonged DGF on patient survivals, renal one year after KT. single center retrospective analysis included all deceased donor KT performed Jan/1998 Dec/2008 (n = 1412). Patients were grouped in quartiles according to (1-5, 6-10, 11-15, >15 days, designated as DGF). The overall incidence was 54.2%. Prolonged associated with...
This study compared the use of static cold storage versus continuous hypothermic machine perfusion in a cohort kidney transplant recipients at high risk for delayed graft function (DGF).In this national, multicenter, and controlled trial, 80 pairs kidneys recovered from brain-dead deceased donors were randomized to or perfusion, transplanted, followed up 12 months. The primary endpoint was incidence DGF. Secondary endpoints included duration DGF, hospital stay, nonfunction, estimated...
In Brief Background De novo use of mammalian target rapamycin inhibitors after kidney transplantation is associated with a concentration-dependent incidence wound healing adverse events (WHAE). The objective this analysis was to compare the WHAE in patients receiving everolimus (EVR) or mycophenolate sodium (MPS). Methods This predefined subanalysis single-center prospective randomized study which 288 transplant recipients tacrolimus and prednisone were for 3 different regimens: rabbit...
There is no evidence on the incidence of subclinical inflammation and scaring lesions in patients receiving tacrolimus (TAC) minimization elimination immunosuppressive regimens.This study analyzed preimplantation, 3 24 months protocol biopsies anti-HLA donor-specific antibodies (DSA) 140 low immunological risk kidney transplant recipients reduced TAC exposure, prednisone, mycophenolate, randomized at to be converted or not sirolimus (SRL).Mean concentrations were 6.0 ± 2.4 ng/mL 5.8 2.2...
Abstract Background Urinary tract infections are frequent complications early after kidney transplantation, and the use of antimicrobial coated catheters in settings other than transplantation has shown promising results for infection prevention. The purpose this study was to compare efficacy Nitrofurazone‐coated silicone urinary with non‐impregnated reducing bacteriuria transplant recipients. Methods This single‐center study, randomized controlled trial at Hospital do Rim, a tertiary...
The risk of death after kidney transplant is associated with the age recipient, presence comorbidities, socioeconomic status, local environmental characteristics and access to health care.To investigate causes factors during first 5 years transplantation.This was a single-center, retrospective, matched case-control study.Using consecutive cohort 1,873 recipients from January 1st 2007 December 31st 2009, there were 162 deaths (case group), corresponding 5-year patient survival 91.4%. Of these...
Abstract Early hospital readmission (EHR) is associated with increased mortality after kidney transplantation. This influenced by population demographics and the comprehensiveness of healthcare system. We investigated incidence risk factors EHR 1‐year patient graft survivals. Methods included all recipients transplant between 2011 2012. excluded younger than 18 years, retransplants who died or lost during index admission. Results Among 1175 recipients, was 26.6%. The main reasons for were...
The identification of the best strategy to manage cytomegalovirus infection is hampered by uncertainties regarding risk/benefit ratios universal prophylaxis versus preemptive therapy, impact indirect effects and associated costs. This study investigated efficacy safety targeted therapy according perceived risk after kidney transplantation.144 adult transplant recipients were enrolled in this 12-month study. None received pharmacological prophylaxis. Only high patients (positive...
Cytomegalovirus (CMV) infection in kidney transplantation has changed its clinical spectrum, mostly due to the current and more effective immunosuppression. In absence of preventive strategies it is associated with significant morbi-mortality. Objective: This study evaluated incidence CMV events effect on outcomes recipients without pharmacological prophylaxis or targeted preemptive treatment. Results: The cohort comprised 802 transplants between 04/30/2014 04/30/2015. majority received...
Background. Mammalian target of rapamycin inhibitors (mTORi), sirolimus (SRL) and everolimus (EVR), have distinct pharmacokinetic/pharmacodynamics properties. There are no studies comparing the efficacy safety de novo use SRL versus EVR in combination with reduced-dose calcineurin inhibitor. Methods. This single-center prospective, randomized study included first kidney transplant recipients receiving a single 3 mg/kg antithymocyte globulin dose, tacrolimus, prednisone, without...
CONTEXT: Despite the recent improvements in performing radical retropubic prostatectomy that have led to a considerable decrease complication rate, erectile dysfunction still represents major problem. Moreover, less invasive treatment options are emerging for not shown satisfactory results managing these patients. OBJECTIVE: To study efficacy and side effects of self-injection therapy men who had become impotent after undergoing due prostate cancer, over period 96 months. DESIGN:...
<b><i>Background:</i></b> This analysis compared efficacy, renal function, and histology in kidney transplant recipients receiving tacrolimus (TAC) combined with everolimus (EVR) or mycophenolate (MPS). <b><i>Methods:</i></b> was a retrospective from randomized trial who received single 3 mg/kg dose of rabbit antithymocyte globulin (r-ATG), TAC, EVR, prednisone (PRED; r-ATG/EVR, <i>n</i> = 85), basiliximab (BAS), PRED (BAS/EVR, 102)...
Abstract: Objectives: The aim of this study was to compare two mini‐incision techniques and judge the impact on quality life, pain, safety living kidney donors. Patients methods: From March through September 2003, a prospective randomized with 60 donors had nephrectomy performed – 30 lombotomy another patients underwent subcostal mini‐incisions. same anesthetic procedure used for both groups. All were evaluated from baseline (T0) day 90 after surgery. Pain evaluation included visual analog...
Hospital do Rim is a high-volume kidney transplant (KT) center located in São Paulo, city with 12.2 million inhabitants. Over the last 18 years, we performed 11 436 KT, 70% of which from deceased donors. To mitigate effects reduction number transplants on waiting list, sequential measures were implemented when COVID-19 was declared pandemic.The first step to provide SARS-COV-2 RT-PCR testing for all symptomatic employees and patients compulsory use personal protective equipment hospital...
Abstract Introduction Several studies and meta‐analysis suggest the mTOR inhibitors are associated with reduced incidence of CMV infection after kidney transplantation, although their effects on high‐risk population have not been investigated thoroughly. Objective This retrospective cohort study investigates association between immunosuppression in D+/R− transplant recipients receiving preemptive therapy. Methods All patients received rabbit anti‐thymocyte globulin, tacrolimus, prednisone...
OBJECTIVE To develop a rat model of erectile dysfunction (ED) after cavernous nerve injury. MATERIALS AND METHODS Given the great similarity between anatomical structure in rats and humans, 24 underwent dissections nerves were identified with aid an operating microscope. Then randomized into two groups: sham‐operated controls bilateral section group. At 3 months surgery, evaluated for their response to apomorphine challenge. RESULTS The challenge was normal all control rats, while there no...
Background. The short-term efficacy and safety of everolimus in combination with tacrolimus have been described several clinical trials. Yet, detailed long-term data comparing the use or mycophenolate kidney transplant recipients receiving are lacking. Methods. This is a 5-y follow-up post hoc analysis prospective trial including 288 patients who were randomized to receive single 3-mg/kg dose rabbit antithymocyte globulin, tacrolimus, (EVR), prednisone (rabbit globulin/EVR, n = 85);...
Abstract Background The use of m TOR inhibitors is associated with lower incidence CMV infections but its effect on viral load has not been investigated. Aims, Materials and Methods This post‐hoc analysis included data from 273 seropositive kidney transplant recipients randomized to receive anti‐thymocyte globulin everolimus ( rAGT / TAC EVR , n = 81), basiliximab BAS 97) or mycophenolate MPS 95). All patients received tacrolimus ) corticosteroids. Preemptive therapy based weekly pp65...
To determine the prevalence of erectile dysfunction (ED) in a specific population and explore potential correlates with lifestyle.This prospective observational study, covering very small rural town, included 2000 men aged > or = 20 years from total 121 831 (51% female 49% male). The International Index Erectile Function was completed by each at their homes over 1-year period. Another questionnaire assessing socio-economic status health-related determinants ED were also completed.All...