A5050042785- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Endometrial and Cervical Cancer Treatments
- RNA modifications and cancer
- Parkinson's Disease Mechanisms and Treatments
- Metal-Catalyzed Oxygenation Mechanisms
- Uterine Myomas and Treatments
- Lipoproteins and Cardiovascular Health
- Pediatric Pain Management Techniques
- Botulinum Toxin and Related Neurological Disorders
- Family and Patient Care in Intensive Care Units
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- ATP Synthase and ATPases Research
- Neurological disorders and treatments
- Sarcoma Diagnosis and Treatment
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Ovarian cancer diagnosis and treatment
- Music Therapy and Health
- Cardiac tumors and thrombi
Michigan State University
2019-2024
Gynecologic Oncology Associates
2024
Memorial Sloan Kettering Cancer Center
2007-2024
Regeneron (United States)
2015-2023
St. Joseph’s Healthcare Hamilton
2023
University of California, San Diego
2022
Kettering University
2022
University of Dayton
2021
Massachusetts Institute of Technology
2016-2018
University of Alabama at Birmingham
2016-2018
Proprotein convertase subtilisin/kexin type 9 monoclonal antibodies can reduce low-density lipoprotein cholesterol (LDL-C) to very low levels when added background lipid-lowering therapy.The safety of alirocumab was evaluated in patients with at least 2 consecutive LDL-C values <25 or <15 mg/dl the ODYSSEY program, follow-up as long 104 weeks.Pooled data from 14 trials were analyzed (double-blind treatment 8 weeks; n = 3,340 alirocumab, 1,894 control [placebo ezetimibe]; representing 4,029...
Alternative splicing of the Pkm gene product generates PKM1 and PKM2 isoforms pyruvate kinase (PK), expression is closely linked to embryogenesis, tissue regeneration, cancer. To interrogate functional requirement for during development homeostasis, we generated germline PKM2-null mice (Pkm2(-/-)). Unexpectedly, despite being primary isoform expressed in most wild-type adult tissues, found that Pkm2(-/-) are viable fertile. Thus, not required embryonic or postnatal development. Loss leads...
The two unrelated miRNAs miR-143 and miR-145, coexpressed from the miR-143/145 cluster, have been proposed to act as tumor suppressors in human cancer, therapeutic benefits of delivering miR-145 tumors reported. In contrast, we found that tumor-specific deletion an autochthonous mouse model lung adenocarcinoma did not affect development. This was consistent with lack endogenous expression normal transformed epithelium. Surprisingly, microenvironment dramatically promoted growth by...
The extracellular microenvironment is an integral component of normal and diseased tissues that poorly understood owing to its complexity. To investigate the contribution lung fibrosis adenocarcinoma progression, two pathologies characterized by excessive stromal expansion, we used mouse models characterize matrix (ECM) composition lung, fibrotic tumors, metastases. Using quantitative proteomics, identified assayed abundance 113 ECM proteins, which revealed robust protein signatures unique...
Animal models that accurately recapitulate the accumulation of alpha-synuclein (α-syn) inclusions, progressive neurodegeneration nigrostriatal system and motor deficits can be useful tools for Parkinson's disease (PD) research. The preformed fibril (PFF) synucleinopathy model in rodents generally displays these PD-relevant features, however, magnitude predictability events is far from established. We therefore sought to optimize α-syn degeneration, understand time course both. Rats were...
Examination of early phases synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development modifying therapies. The rat alpha-synuclein (α-syn) preformed fibril (PFF) model induces synchronized that recapitulates pathological features Parkinson's (PD) can be used study progression. In this model, phosphorylated α-syn (pSyn) inclusion-containing neurons reactive microglia (major...
In this study, we evaluated the effects of viewing an educational videotape about pediatric anesthesia on measures parental knowledge and preoperative anxiety using a randomized, controlled design.During their routine visit, 85 parents children scheduled to undergo ambulatory surgical procedures under general were randomized view either experimental or control with no medical content. Before immediately after assigned videotape, completed situational (State-Trait Anxiety Inventory-State),...
ObjectivesDespite maximally tolerated statin therapy, many patients with high cardiovascular risk, or without heterozygous familial hypercholesterolemia may require additional low-density lipoprotein cholesterol (LDL-C) reduction. We report pooled alirocumab (ALI) efficacy and safety data from eight Phase 3 trials in 4629 patients, receiving background therapy.Material methodsStudies were by ALI dose control: 75/150 mg every 2 weeks (Q2W; increased to 150 Q2W at Week 12 based on 8 LDL-C)...
Introduction The alpha-synuclein ( α -syn) preformed fibril (PFF) model of Parkinson’s disease (PD) is widely used in rodents to understand the mechanisms contributing progression pathology and neurodegeneration disorder. While time course -syn PFF rat has been well characterized, it more challenging determine reliable reproducible behavior impairments. This mainly due injections resulting a partial nigrostriatal lesion that make motor anomalies subtle difficult detect, just as patients with...
In this study, we evaluated the effects of viewing an educational videotape about pediatric anesthesia on measures parental knowledge and preoperative anxiety using a randomized, controlled design.During their routine visit, 85 parents children scheduled to undergo ambulatory surgical procedures under general were randomized view either experimental or control with no medical content. Before immediately after assigned videotape, completed situational (State-Trait Anxiety Inventory-State),...
Human and animal studies have shown that exposure to the organochlorine pesticide dieldrin is associated with increased risk of Parkinson's disease (PD). Previous work showed developmental neuronal susceptibility MPTP toxicity in male C57BL/6 mice, possibly via changes dopamine (DA) packaging turnover. However, relevance model PD pathophysiology has been questioned. We therefore studied dieldrin-induced neurotoxicity α-synuclein (α-syn)-preformed fibril (PFF) model, which better reflects...
Preclinical studies show a link between subthalamic nucleus (STN) deep brain stimulation (DBS) and neuroprotection of nigrostriatal dopamine (DA) neurons, potentially through brain-derived neurotrophic factor (BDNF) signaling. However, the question whether DBS STN can be disease-modifying in Parkinson's disease (PD) remains unanswered. In particular, impact on α-synuclein (α-syn) aggregation, inclusion-associated neuroinflammation, BDNF levels has yet to examined context synucleinopathy. To...
Alternative splicing of the Pkm gene product generates PKM1 and PKM2 isoforms glycolytic enzyme pyruvate kinase. expression is associated with embryogenesis, tissue regeneration, cancer. also kinase isoform expressed in most wild-type adult tissues, restricted primarily to skeletal muscle, heart, brain. To interrogate functional requirement for during tumor initiation an autochthonous mouse model soft sarcoma (STS), we used a conditional Pkm2 allele (Pkm2 fl ) abolish expression. deletion...
Abstract Purpose: Tumor genomic profiling is increasingly used to guide treatment strategy in patients with cancer. We integrated tumor genomic, clinical demographic, and response data assess how prospective tumor-normal sequencing impacted selection cervical Experimental Design: Cervical cancers were prospectively analyzed using the MSK-IMPACT (Memorial Sloan Kettering Cancer Center – Integrated Mutation Profiling of Actionable Targets) next-generation panel. Clinical data, including...
Parents' anxiety about their children's anesthesia may adversely affect the outcomes and compromise quality of informed consent.Studies these issues have been limited by lack validated measures parental knowledge surrounding anesthesia. In present study, we evaluated psychometric properties Amsterdam Preoperative Anxiety Information Scale (APAIS) Standard Anesthesia Learning Test (SALT) among 85 parents who participated in an evaluation effects a videotape pediatric The results supported...
In this double-blind study, 301 patients with subjective and objective signs of sore throat were randomly assigned to flurbiprofen 8.75 mg (n = 129), 12.5 43) or placebo (demulcent lozenge without active drug [n 129]). Efficacy was assessed by changes in rating scales primarily after a single dose also over 4-day period. Flurbiprofen superior number efficacy parameters, notably soreness. Throat soreness significantly reduced 15 minutes (p < 0.05), effects sustained for at least 2 hours...
Parents' anxiety about their children's anesthesia may adversely affect the outcomes and compromise quality of informed consent.Studies these issues have been limited by lack validated measures parental knowledge surrounding anesthesia. In present study, we evaluated psychometric properties Amsterdam Preoperative Anxiety Information Scale (APAIS) Standard Anesthesia Learning Test (SALT) among 85 parents who participated in an evaluation effects a videotape pediatric The results supported...
The flurbiprofen 8.75 mg lozenge is a novel formulation that combines demulcent effect with the analgesic activity of non-steroidal anti-inflammatory drug. Previous controlled clinical studies have demonstrated single- and multi-dose efficacy these lozenges over placebo. current study reflected treatment sore throat in general practice, investigating multiple dose where patients also had access to concomitant antibiotics rescue medication. placebo was confirmed: there significant difference...
Nested PCR was performed on individually isolated Giardia lamblia cysts in replicates of 50 for sets 1, 2, 3, 4, 5, 7, and 10 cysts. Amplification ranged from 80% 1 cyst to 100% The results suggest that nested is well adapted G. single-cyst detection.