A5101720727- Retinal Development and Disorders
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- MicroRNA in disease regulation
- Pregnancy and preeclampsia studies
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
First Affiliated Hospital of Xiamen University
2023
OU Health
2016
University of Oklahoma Health Sciences Center
2016
Abstract Large-scale transcriptomic data are crucial for understanding the molecular features of hepatocellular carcinoma (HCC). By integrating 15 datasets HCC clinical samples, first version HCCDB was released in 2018. The meta-analysis differentially expressed genes and prognosis-related across multiple provides a systematic view altered biological processes inter-patient heterogeneities with high reproducibility robustness. After four years, database needs to integrate recently published...
Background: Preeclampsia (PE) is a severe pregnancy complication associated with autophagy. Objective: This research sought to uncover autophagy-related genes in pre-eclampsia through bioinformatics and machine learning. Methods: GSE75010 from the GEO series was subjected WGCNA identify key modular PE. Autophagy retrieved THANATOS overlapped yield PErelated autophagy genes. Furthermore, crucial step involved utilization of two learning algorithms (LASSO SVM-RFE) for dimensionality reduction....