A5027017961- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Diet, Metabolism, and Disease
- Biochemical Analysis and Sensing Techniques
- Agriculture and Biological Studies
- Coleoptera Taxonomy and Distribution
- Lipid Membrane Structure and Behavior
- Regulation of Appetite and Obesity
- Liver Disease Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Endoplasmic Reticulum Stress and Disease
- Ear Surgery and Otitis Media
- Lipid metabolism and disorders
- Neuroscience of respiration and sleep
- Blood Coagulation and Thrombosis Mechanisms
- Ion Channels and Receptors
- Caveolin-1 and cellular processes
- Blood properties and coagulation
- Ion channel regulation and function
- Neurobiology and Insect Physiology Research
- Cellular transport and secretion
- Plant Molecular Biology Research
Bayreuth Medical Center
2021
University of Tübingen
2004-2007
TH Bingen University of Applied Sciences
2007
University of Hohenheim
2004
Klinikum rechts der Isar
1992
Technical University of Munich
1992
The large conductance voltage- and Ca 2+ -activated potassium (BK) channel has been suggested to play an important role in the signal transduction process of cochlear inner hair cells. BK channels have shown be composed pore-forming α-subunit coexpressed with auxiliary β1-subunit. Analyzing hearing function phenotype α-(BKα –/– ) β1-subunit (BKβ1 knockout mice, we demonstrate normal structure BKβ1 mice. During first 4 postnatal weeks also, BKα mice most surprisingly did not show any obvious...
Abstract Mutations of the human otoferlin gene lead to an autosomal recessive nonsyndromic form prelingual, sensorineural deafness (deafness 9, DFNB9). Several studies have demonstrated expression in inner ear and brain, suggested a role Ca 2+ ‐triggered exocytosis. So far, profiles were solely based on detection mRNA. Here, we analysed protein mRNA using immunohistochemistry, situ hybridization RT‐PCR neonatal mature Wistar rat tissue. In agreement with previous studies, was found brain...
Outer hair cells (OHCs) are innervated by type II afferent fibers of as yet unknown function. It is still a matter debate whether OHCs perform exocytosis. If so, they would require presynaptic Ca<sup>2+</sup> channels at their basal poles where the make contacts. Here we show that L-type channel currents (charge carrier, 10 mm Ba<sup>2+</sup>) present in neonatal [postnatal day 1 (P1) to P7] decreased from ∼170 ∼50 pA approximately onset hearing. Ba<sup>2+</sup> could hardly be measured...
Thyroid hormone (TH or T3) and TH-receptor beta (TRbeta) have been reported to be relevant for cochlear development hearing function. Mutations in the TRbeta gene result deafness associated with resistance TH syndrome. The effect of TRalpha1 on neither function nor T3 target genes has described date. It is also uncertain whether can act simultaneously different within a single cell. We focused two concomitantly expressed outer hair cell genes, potassium channel Kcnq4 motor protein prestin...
Thyroid hormone (TH) is essential for the development of hearing. Lack TH in a critical developmental period from embryonic day 17 to postnatal 12 (P12) rats and mice leads morphological functional deficits organ Corti auditory pathway. We investigated effects on inner hair cells (IHCs) using patch-clamp recordings, capacitance measurements, immunocytochemistry hypothyroid athyroid Pax8 −/− mice. Spontaneous evoked Ca 2+ action potentials (APs) were present control IHCs P3–P11 vanished...
Ciliary neurotrophic factor (CNTF) signals via a tripartite receptor complex consisting of the glycosyl-phosphatidylinositol (GPI)-anchored CNTF (CNTF-R), leukaemia inhibitory (LIF-R) and interleukin-6 (IL-6) signal transducer gp130. We have recently reported that gp130 is endogenously expressed in polarised epithelial model cell line Madin-Darby canine kidney (MDCK) we demonstrated preferential basolateral localisation this protein. In present study show MDCK cells also express LIF-R...
The 10-member SLC26 gene family encodes anion exchangers of which SLC26A5 appears to be restricted the outer hair cells inner ear. Here, so-called prestin protein acts as a molecular motor, thought responsible for active mechanical amplification in mammalian cochlea. We introduce special characteristics may have relevance other members well. As such, data point characteristic transcriptional control mechanism thyroid hormone surprisingly takes role not only an enhancer expression, but also...
Background Severe forms of dyslipidemia (with triglyceride (TG) levels exceeding 2000 mg / dL) are rare in diabetes mellitus (T2DM). Excessive fructose consumption can lead to severe hypertriglyceridemia by de novo hepatic lipogenesis.
s: First meeting of the European Thrombosis Research Organization Working Party on factor XIII: PDF Only