A. Santos-Fandila

ORCID: 0000-0002-7477-5752
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About
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Research Areas
  • Diet and metabolism studies
  • Nutrition and Health in Aging
  • Infant Nutrition and Health
  • Digestive system and related health
  • Neuroscience and Neuropharmacology Research
  • Muscle metabolism and nutrition
  • Analytical Chemistry and Chromatography
  • Metabolism and Genetic Disorders
  • Metabolomics and Mass Spectrometry Studies
  • Gut microbiota and health
  • Coenzyme Q10 studies and effects
  • Analytical chemistry methods development
  • Folate and B Vitamins Research
  • Breastfeeding Practices and Influences
  • Receptor Mechanisms and Signaling
  • Frailty in Older Adults
  • Sulfur Compounds in Biology
  • Advanced Chemical Sensor Technologies
  • Metabolism, Diabetes, and Cancer
  • Ion channel regulation and function
  • Glycosylation and Glycoproteins Research
  • Zebrafish Biomedical Research Applications

Abbott (Spain)
2013-2024

New York University Press
2017

Cambridge University Press
2017

Universidad de Granada
2013-2015

Abbott (United Kingdom)
2014

Coenzyme Q (CoQ) is a key component of the mitochondrial respiratory chain, but it also has several other functions in cellular metabolism. One them to function as an electron carrier reaction catalyzed by sulfide:quinone oxidoreductase (SQR), which catalyzes first hydrogen sulfide oxidation pathway. Therefore, SQR may be affected CoQ deficiency. Using human skin fibroblasts and two mouse models with primary deficiency, we demonstrate that severe deficiency causes reduction levels activity,...

10.15252/emmm.201606345 article EN cc-by EMBO Molecular Medicine 2016-11-17

Human milk oligosaccharides (HMO) are involved in many biological functions influencing infant health. Although HMO act locally at the intestine, recent evidence has demonstrated that partially incorporated into systemic circulation of breast-fed infants. In last few years, a large amount research been conducted using preclinical models to uncover new HMO. The aim this study was evaluate absorption and urine excretion rats. We administered single oral dose following HMO: 2'-fucosyllactose...

10.1017/s0007114516004554 article EN British Journal Of Nutrition 2017-01-28

Introduction The main cause of insulin resistance in childhood is obesity, which contributes to future comorbidities as adults. Although high-calorie diets and lack exercise contribute metabolic disease development, food quality rather than the quantity macronutrients more important density. purpose present study was examine effects changing carbohydrates from rapidly slowly digestible on composition gut microbiota profiles functional pathways growing rats with obesity due a high-fat diet...

10.3389/fnut.2022.992682 article EN cc-by Frontiers in Nutrition 2022-11-30

Abstract Background Frailty is a key element in healthy ageing which muscle performance plays main role. Beta‐hydroxy‐beta‐methylbutyrate (HMB) supplementation has shown favourable effects modulating protein synthesis, improving mass and function interventional studies. Decreased age‐related endogenous HMB levels have been previous The aim of the present study to assess whether there an association between plasma frailty. Methods Data from 1290 subjects (56.98% women; mean ± standard...

10.1002/jcsm.13394 article EN cc-by-nc-nd Journal of Cachexia Sarcopenia and Muscle 2023-12-13

Supplementation with β-hydroxy β-methyl butyrate (HMB) appears to be effective in preserving muscle older adults. However, the association between endogenously produced HMB frailty has not been studied people chronic disease. The purpose of this study is explore whether an exists endogenous levels and status adults type-2 diabetes mellitus (T2DM). Data were taken from Toledo Study Healthy Ageing, a community-dwelling aged (65 years+) cohort. Frailty was assessed at baseline 2.99 median years...

10.1016/j.jnha.2024.100229 article EN cc-by-nc-nd The journal of nutrition health & aging 2024-04-09
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