A5055893061- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Cystic Fibrosis Research Advances
- Glioma Diagnosis and Treatment
- Urinary Tract Infections Management
- Hemoglobinopathies and Related Disorders
- Atomic and Subatomic Physics Research
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Cellular Mechanics and Interactions
- Neurogenesis and neuroplasticity mechanisms
- Lanthanide and Transition Metal Complexes
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Neonatal Respiratory Health Research
- Fetal and Pediatric Neurological Disorders
- Brain Metastases and Treatment
- Advanced Neuroimaging Techniques and Applications
- Barrier Structure and Function Studies
- Bone and Joint Diseases
Case Western Reserve University
2013-2019
Cleveland Clinic Lerner College of Medicine
2013-2016
University Hospitals Cleveland Medical Center
2013-2014
Rainbow Babies & Children's Hospital
2013
Glioblastoma is the most common and aggressive primary brain tumour. Standard of care consists surgical resection followed by radiotherapy concomitant maintenance temozolomide (temozolomide/radiotherapy→temozolomide). Corticosteroids are commonly used perioperatively to control cerebral oedema frequently continued throughout subsequent treatment, notably radiotherapy, for amelioration side effects. The effects corticosteroids such as dexamethasone on cell growth in glioma models patient...
BACKGROUNDHepatic steatosis is a common form of cystic fibrosis associated liver disease (CFLD) seen in an estimated 15%-60% patients with (CF).The pathophysiology and health implications hepatic remain largely unknown.In the general population, strongly insulin resistance type 2 diabetes.Cystic related diabetes (CFRD) impacts 40%-50% CF adults characterized by both insufficiency resistance.We hypothesized that CFRD would have higher levels than without diabetes. AIMTo determine whether to...
Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope available MRI has expanded over the years with emergence molecular specifically targeted biological markers. Unfortunately, synergistic application more than a single agent limited by MRI's ability only dynamically measure at time. In this study, new Dual Contrast - Fingerprinting (DC MRF)...
Background Cystic fibrosis (CF) patients would benefit from a safe and effective tool to detect early-stage, regional lung disease allow for early intervention. Magnetic Resonance Imaging (MRI) is safe, non-invasive procedure capable of providing quantitative assessments without ionizing radiation. We developed rapid normalized T1 MRI technique in early-stage CF patients. Materials Methods Conventional multislice, pulmonary relaxation time maps were obtained 10 adult with normal spirometry 5...
Pyelonephritis is a bacterial infection of the kidney and most commonly caused by Escherichia coli. Recurrent infections can cause significant renal inflammation fibrosis ultimately resulting in declining function. Before improved clinical management prevention pyelonephritis be instituted, reliable animal model must established order to study mechanisms progression, recurrence, therapeutic efficacy. The transurethral closely mimics human but exhibits considerable variation due its reliance...
Chronic kidney disease (CKD) occurs in over one‐third of patients with sickle cell (SCD) and can progress to end‐stage renal disease. Unfortunately, current clinical assessments function are insensitive early‐stage CKD. Previous studies have shown that diffusion magnetic resonance imaging (MRI) sensitively detect regional microstructural changes associated However, previous MRI SCD been largely limited the detection iron deposition assessed by T 2 * relaxometry. In this pilot study, we...
Purpose The Dixon techniques provide uniform water‐fat separation but require multiple image sets, which extend the overall acquisition time. Here, an alternative rapid single method, lipid elimination with echo‐shifting N/2‐ghost (LEENA), was introduced. Methods LEENA method utilized a fast imaging steady‐state free precession sequence to obtain k‐space dataset in successive lines are acquired allow fat magnetization precess 180°. data were then unghosted using either image‐domain (LEENA‐S)...
Pyelonephritis is a bacterial infection of the kidney and most commonly caused by Escherichia coli. Recurrent infections can cause significant renal inflammation fibrosis ultimately resulting in declining function. Before improved clinical management prevention pyelonephritis be instituted, reliable animal model must established order to study mechanisms progression, recurrence, therapeutic efficacy. The transurethral closely mimics human but exhibits considerable variation due its reliance...