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A5115943034
Research Areas
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
Department of Medical Sciences
2025
ETH Zurich
2025
Abstract Temozolomide kills cancer cells by forming O6-methylguanine (O6-MeG), which leads to cell cycle arrest and apoptosis. However, O6-MeG repair O6-methylguanine-DNA methyltransferase (MGMT) contributes drug resistance. Characterizing genomic profiles of could elucidate how accumulation is influenced repair, but there are no methods map locations O6-MeG. Here, we developed an immunoprecipitation- polymerase-stalling-based method, termed O6-MeG-seq, locate across the whole genome at...
10.1093/nar/gkae1320
article
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cc-by-nc
Nucleic Acids Research
2025-01-11
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