A5068166024- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Biochemical and Molecular Research
- Enzyme Structure and Function
- Cancer-related Molecular Pathways
- Protein Tyrosine Phosphatases
- Diet, Metabolism, and Disease
- Amino Acid Enzymes and Metabolism
- ATP Synthase and ATPases Research
- Cancer Research and Treatments
- TGF-β signaling in diseases
Universitat de Barcelona
2013-2018
Institut d'Investigació Biomédica de Bellvitge
2016-2018
Departament de Salut
2013-2018
Ajuntament de L’Hospitalet
2013-2014
Institut de l'Information Scientifique et Technique
2013-2014
In human cancers, transforming growth factor-β1 (TGF-β1) plays a dual role by acting as both tumor suppressor and promoter of metastasis. Although TGF-β1 contributes to the metabolic reprogramming cancer cells tumor-associated stromal cells, little is known molecular mechanisms connecting this cytokine with enhanced glycolysis. PFKFB3 homodymeric bifunctional enzyme, belonging family 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases, that controls conversion fructose-6-phosphate...
on C12orf5, with data DNA/RNA, the protein encoded and where gene is implicated. Identity names: FR2BP, TIGAR
Review on PFKFB2, with data DNA/RNA, the protein encoded and where gene is implicated. IdentityOther names: PFK-2/FBPase-2 HGNC (Hugo): PFKFB2 Location: 1q32.2 Local orderThe human located chromosome 1 at position 1q31-q32.2(GeneCards) (Fig. 1). DNA/RNA DescriptionThe composed of 15 exons spanning 22617 bp (GenBank: AJ005577.1).This has 9 transcripts; two them have been reported to codify a three contain an open reading frame, but no identified.The transcripts are derived from different...
strand (MGI).For a comparison of the gene Homo sapiens, mouse, rat, cattle, chimpanzee and domestic dog see: (MGI).Also for all species known tree, Treefam database.Figure 1.Localization human PFKFB3 by in situ hybridization.