A5062743577- Microfluidic and Capillary Electrophoresis Applications
- Analytical Chemistry and Sensors
- Electrochemical Analysis and Applications
- Advanced Chemical Sensor Technologies
- Biosensors and Analytical Detection
- Atomic and Molecular Physics
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Chromatography
- Analytical chemistry methods development
- Electrochemical sensors and biosensors
- Mass Spectrometry Techniques and Applications
- Gas Sensing Nanomaterials and Sensors
- Muon and positron interactions and applications
- Electrowetting and Microfluidic Technologies
- X-ray Spectroscopy and Fluorescence Analysis
- Water Quality Monitoring and Analysis
- Hearing Impairment and Communication
- Advanced Chemical Physics Studies
- Particle accelerators and beam dynamics
- Spectroscopy and Laser Applications
- Quantum Chromodynamics and Particle Interactions
- Nuclear physics research studies
- Particle physics theoretical and experimental studies
- Neutrino Physics Research
University of Basel
2016-2025
Rochester Institute of Technology
2006-2024
German Cancer Research Center
2011-2023
Heidelberg University
2011-2023
Montreal Children's Hospital
2011-2023
Semmelweis University
2011-2023
University of North Texas
2021
University of Michigan–Ann Arbor
2021
Boston Medical Center
2021
Boston University
2021
Sensitive detection in microfluidic analytical devices is a challenge because of the extremely small volumes available. Considerable efforts have been made lately to further address this aspect and investigate techniques other than fluorescence. Among newly introduced are optical methods chemiluminescence, refraction thermooptics, as well electrochemical amperometry, conductimetry potentiometry. Developments also progress create miniaturized plasma-emission spectrometers sensitive detectors...
With currently known input physics and computer simulations in one dimension, a self-consistent treatment of core-collapse supernovae does not yet lead to successful explosions, while two-dimensional models show some promise. Thus, there are strong indications that the delayed neutrino mechanism works combined with multidimensional convection for unstable layers (possibly aid rotation, magnetic fields and/or still existent uncertainties opacities). On other hand, is need provide correct...
Oncogenic BRAF/Ras or NF1 loss can potentially trigger oncogene-induced senescence (OIS) through activation of the mitogen-activated protein kinase (MAPK) pathway. Somatic genetic abnormalities affecting this pathway occur in majority pilocytic astrocytomas (PA), most prevalent brain neoplasm children. We investigated whether OIS is induced PA.We tested expression established markers three independent cohorts sporadic PA. also assessed for vitro, using forced wild-type and V600E-mutant BRAF...
A portable capillary electrophoresis instrument featuring an automated, robust, valve-based injection system was developed. This significantly facilitates operation in the field compared to previous approaches. These generally required delicate manual operations which are difficult perform outside laboratory environment. The novel relies on pressurized air for solution delivery and a micromembrane pump sample aspiration. Contactless conductivity detection employed its versatility low power...
Abstract A better understanding of the characteristics axial contactless conductivity cell could be obtained by carefully studying effect geometry on its frequency behavior. good fit between theoretical and experimental results shows that conductometric detector can effectively described simplest possible equivalent circuitry consisting a capacitor, resistor, second capacitor. The constant is largely defined length gap electrodes. effective electrode size thus not related to dimensions real...
The new features of the capacitively coupled contactless conductivity detector for capillary electrophoresis described are higher peak-to-peak excitation voltages cell up to 250 V, a pick-up amplifier in close proximity electrode and synchronous detection. electrical performance was characterized found follow readily predictable patterns. alterations led signal strength, better signal-to-noise ratio (S/N) improved stability. 3 × S/N detection limits obtained inorganic cations anions range...
Contactless conductivity detection was carried out on a planar electrophoresis device by capacitive coupling using an ac excitation voltage of 500 V(p-p) and frequency 100 kHz. It possible to carry in this way through cover plate 1 mm thickness. Better sensitivity is obtained, however, placing the electrodes into troughs that allow tighter separation channel. The 3 x S/N limits are 0.49, 0.41, 0.35 microM for small inorganic ions K+, Na+, Mg2+. heavy metals demonstrated with example Mn2+,...
Abstract The signal‐to‐noise ratio of a contactless conductivity detector for capillary electrophoresis was examined different cell arrangements and operating parameters. best ratios, hence the detection limits, are obtained frequencies which give highest sensitivity. Comparative experiments three excitation voltages (20, 100, 200 V pp ) showed that ratios were achieved voltage . Low background electrolyte solution is mandatory to obtain lowest noise levels, also improvement on applying high...
Abstract A new portable capillary electrophoresis instrument with capacitively coupled contactless conductivity detection was developed and optimized for the sensitive field measurements of ionic compounds in environmental samples. It is powered by batteries high voltage modules are capable delivering up to 15 kV at either polarity more than one working day. Inorganic cations anions, including ions heavy metals arsenate, could be determined limits range from about 0.2 1 μM. The tested a...
The simplified amperometric detection scheme demonstrated is based on the working and electrophoretic ground electrodes only. latter serves as counter pseudo-reference well. It shown via successful determination of neurotransmitters, ascorbic acid phenols gold or platinum that this approach feasible for a channel separation device. Also presented carbohydrates amino acids with copper electrodes. results were found to be similar those obtained conventional capillary systems detection, albeit...
The detection of alkali, alkaline earth and heavy metal ions with a high-voltage capacitively coupled contactless conductivity detector (HV-C4D) was investigated. Eight ammonium could be separated in less than 4 min limits the order 5×10-8 M. metals Mn2+, Pb2+, Cd2+ Fe2+ , Zn2+, Co2+, Cu2+ Ni2+ also successfully resolved 10 mM 2-(N-morpholino)ethanesulfonic acid/DL-histidine (MES/His)-buffer. showed an indirect response. for were determined to range from about 1 5 νM.