Yu Zhang

ORCID: 0000-0002-7535-9080
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About
Contact & Profiles
Research Areas
  • Genetics and Neurodevelopmental Disorders
  • Sperm and Testicular Function
  • Congenital heart defects research
  • Cardiomyopathy and Myosin Studies
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Sexual Differentiation and Disorders
  • Metallic Glasses and Amorphous Alloys
  • Signaling Pathways in Disease
  • Epigenetics and DNA Methylation
  • Bipolar Disorder and Treatment
  • Characterization and Applications of Magnetic Nanoparticles
  • Connective tissue disorders research
  • Neuroscience of respiration and sleep
  • Cardiovascular Effects of Exercise
  • High Altitude and Hypoxia
  • Magnetic and Electromagnetic Effects
  • Bone fractures and treatments
  • Climate Change and Health Impacts
  • Ubiquitin and proteasome pathways
  • Mesenchymal stem cell research
  • Estrogen and related hormone effects
  • Cancer-related Molecular Pathways
  • Genomic variations and chromosomal abnormalities
  • 14-3-3 protein interactions
  • Angiogenesis and VEGF in Cancer

Nanchang University
2022

Qinghai University
2021

Hebei University of Chinese Medicine
2021

Southeast University
2003-2020

Zhejiang Wanli University
2019

Wenzhou Medical University
2018

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018

Northeast Normal University
2009

The Masquelet's induced membrane technique for repairing bone defects has been demonstrated to be a promising treatment strategy. Previous studies have shown that the vessel density of is decreased in late stage formation, which consequently disrupts healing process. However, relatively little known about certain mechanisms degeneration tissue and whether promotion angiogenesis membranes can improve regeneration. Here, we showed Delta-like ligand 4/ Notch homolog 1 (Dll4/Notch1) pathway was...

10.1038/s12276-018-0062-9 article EN cc-by-nc-nd Experimental & Molecular Medicine 2018-04-01

Abstract Cardiac hypertrophy is a common pathological change in patients with progressive cardiac function failure, which can be caused by hypertrophic cardiomyopathy (HCM), dilated (DCM) or arterial hypertension. Despite years of study, there still limited knowledge about the underlying molecular mechanisms for hypertrophy. NDUFA7, subunit NADH:ubiquinone oxidoreductase (complex I), has been reported to novel HCM associated gene. However, biological role NDUFA7 heart remains unknown. In...

10.1111/jcmm.15921 article EN cc-by Journal of Cellular and Molecular Medicine 2020-09-29

Abstract Cardiac hypertrophy is a compensatory response to pathological stimuli, ultimately progresses cardiomyopathy, heart failure, or sudden death. Although many signaling pathways have been reported be involved in the hypertrophic process, it still not fully clear about underlying molecular mechanisms for cardiac hypertrophy. Hedgehog acyltransferase‐like (Hhatl), sarcoplasmic reticulum‐resident protein, exhibits high expression and muscle. However, biological role of Hhatl remains...

10.1002/jcp.30106 article EN Journal of Cellular Physiology 2020-10-14

Centrosome aberrations have been implicated in the development and progression of breast cancer. Our previous worked show that centrosomal protein 70 (Cep70) regulates cancer growth metastasis. However, it remains elusive whether Cep70 is sensitivity anti-microtubule drug paclitaxel Here we provide evidence a mediator Cell proliferation assays expression correlates with cell lines. In addition, varies when altering level. Mechanistic studies reveal interacts tubulin, promotes ability to...

10.3390/ijms18061267 article EN International Journal of Molecular Sciences 2017-06-20

Abstract Background Abnormal white matter is a common neurobiological change in bipolar disorder, and dysregulation of myelination oligodendrocytes (OLs) the cause. Transmembrane protein 108 ( Tmem108 ), as susceptible gene expressed higher OL lineage cells than any other central nervous system. Moreover, mutant mice exhibit mania-like behaviors, belonging to one signs disorder. However, it unknown whether regulates OLs. Results expression corpus callosum decreased with development,...

10.1186/s13041-022-00918-7 article EN cc-by Molecular Brain 2022-04-11

ABSTRACT Müllerian-inhibiting substance ( Mis , or anti-müllerian hormone, Amh ), a member of TGF-β superfamily, as initiator key regulator in sexual development has been well documented some vertebrates, especially fish. However, its functional role not identified yet reptiles. Here we characterized the gene Chinese soft-shelled turtle Pelodiscus sinensis (P. sinensis) typical reptilian species exhibiting ZZ/ZW sex chromosomes. The mRNA was initially expressed male embryonic gonads by stage...

10.1101/708073 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2019-07-19

The present study was proposed to investigate the brain injury under acute hypobaric hypoxia following alteration in mRNA expression and stress markers a time-dependent manner. SD clean graded male rats were randomly divided into four groups for this experimental injury, control group at Xining (altitude, 2270m) treatment with different time exposure day1, day2, day3 7000m) chamber. After exposure, tissues collected. level of VEGF HIF1-α assessed using qRT-PCR. oxidative superoxide dismutase...

10.52403/ijrr.20211031 article EN International Journal of Research and Review 2021-10-20
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