A5101988070- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Sexual Differentiation and Disorders
- Reproductive biology and impacts on aquatic species
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Virtual Reality Applications and Impacts
- Reproductive Biology and Fertility
- Advanced Algebra and Geometry
- Hormonal and reproductive studies
- Aortic aneurysm repair treatments
- Regional Economic Development and Innovation
- Flow Experience in Various Fields
- Analytic and geometric function theory
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Cytokine Signaling Pathways and Interactions
- Tactile and Sensory Interactions
- Mind wandering and attention
- Ubiquitin and proteasome pathways
- Economic and Technological Developments in Russia
- Analytic Number Theory Research
- Aortic Disease and Treatment Approaches
- Advanced Sensor and Energy Harvesting Materials
Zhejiang Wanli University
2017-2024
Institute of Geographic Sciences and Natural Resources Research
2024
Chinese Academy of Sciences
2000-2024
Institute of Software
2019-2021
Army Medical University
2016-2019
Tianjin Chest Hospital
2015
Baylor College of Medicine
2008
Institute of Oceanology
2007
Making males and back again Temperature-dependent sex determination occurs in many reptilian species. An epigenetic mechanism is presumed to be at work, but thus far it has not been identified. Ge et al. show that the red-eared slider turtle, an modifier, histone demethylase KDM6B, binds promoter of dominant male gene activate development (see Perspective by Georges Holleley). Knock down expression embryos destined turn into females. Science , this issue p. 645 ; see also 601
The molecular mechanism underlying temperature-dependent sex determination (TSD) has been a long-standing mystery; in particular, the thermo-sensitive genetic triggers for gonadal differentiation are largely unknown. Here, we characterized conserved DM domain gene, Dmrt1, red-eared slider turtle Trachemys scripta (T. scripta), which exhibits TSD. We found that Dmrt1 temperature-dependent, sexually dimorphic expression pattern, preceding differentiation, and is capable of responding rapidly...
In vertebrates, the primary sex-determining signals that initiate sexual development are remarkably diverse, ranging from complete genetic to environmental cues. However, no sex determination-related genes have been functionally identified in reptiles. Here, we characterized a conserved DM domain gene, Dmrt1, Chinese soft-shelled turtle Pelodiscus sinensis (P. sinensis), which exhibits ZZ/ZW chromosomes. Dmrt1 exhibited early male-specific embryonic expression, preceding onset of gonadal...
Autophagy critically contributes to metabolic reprogramming and chromosomal stability. It has been reported that monoallelic loss of the essential autophagy gene BECN1 (encoding BECN1/Beclin 1) promotes cancer development progression. However, mechanism by which is inactivated in malignancy remains largely elusive. We have previously a tumor suppressor role ABHD5 (abhydrolase domain containing 5), co-activator PNPLA2 (patatin like phospholipase 2) colorectal carcinoma (CRC). Here we report...
Abstract The efficacy of Fluorouracil (FU) in the treatment colorectal cancer (CRC) is greatly limited by drug resistance. Autophagy has been implicated chemoresistance, but role selective autophagic degradation regulating chemoresistance remains unknown. In this study, we revealed a critical ABHD5 charging CRC sensitivity to FU via uracil yield. We demonstrated that localizes lysosome and interacts with PDIA5 prevent from interacting RNASET2 inactivating RNASET2. deficiency releases...
Lung cancer is one of the primary causes mortality worldwide and drug resistance key contributing factor which results in failure lung chemotherapy. Previous studies have shown that microRNA (miR)‑10a was involved reversal cisplatin (DDP) numerous types tumors; however, underlying mechanism action this remains to be fully elucidated. In present study, miR‑10a silencing human DDP‑resistant A549/DDP cells demonstrated improve DDP sensitivity, apoptosis, intracellular rhodamine‑123 content as...
Anti-Müllerian hormone (
The imitation of pain sensation in Virtual Reality is considered valuable for safety education and training but has been seldom studied. This paper presents Douleur, a wearable haptic device that renders intensity-adjustable sensations with chemical stimulants. Different from mechanical, thermal, or electric stimulation, chemical-induced more close to burning long-lasting. Douleur consists microfluidic platform precisely emits capsaicin onto the skin microneedling component help stimulant...
Abstract SOX8, which belongs to SOXE transcription factor subfamily together with SOX9, participates in sex differentiation and testicular development by enhancing the function of SOX9 mammals. However, functional role SOX8 has not yet been identified any non-mammalian vertebrates. Here, we found Chinese soft-shelled turtle Pelodiscus sinensis that exhibited male-specific higher expression from stage 14 18, critical period determination, prior onset gonadal differentiation. In addition, was...
The degree and quality of instructor-student interactions are crucial for students' engagement, retention, learning outcomes. However, such limited in live online lectures, where instructors no longer have access to important cues as raised hands or facial expressions at the time teaching. As a result, cannot fully understand progresses. This paper presents an explorative study investigating how presenters perceive react audience flow prediction when giving live-stream which has not been...
Abstract Exogenous estrogen have shown their feminization abilities during the specific sex differentiation period in several reptiles. However, regulatory mechanism and downstream genes of remain elusive. In present study, 17β-estradiol (E2), as well drugs antagonists and/or agonists receptors, were employed to figure out molecular pathway involved E2-induced Chinese soft-shelled turtles, an important aquaculture species China. E2 treatment led typical female characteristics gonads ZZ...
ABSTRACT KDM6B-mediated epigenetic modification of the testicular regulator Dmrt1 has previously been identified as primary switch male pathway in a temperature-dependent sex-determination (TSD) system; however, molecular network female not yet established. Here, we have functionally characterized for first time an upstream pathway, forkhead transcription factor FOXL2, Trachemys scripta, turtle species with TSD system. FOXL2 exhibited female-specific expression patterns before onset gonadal...
Abstract Estrogen signaling exerts a decisive role in female sex determination and differentiation chicken fish. Aromatase encoded by Cyp19a1 is the key enzyme that catalyzes conversion of androgen to estrogen. Correlative analyses implicate potential involvement aromatase reptilian sexual development, however, direct genetic evidence lacking. Herein, we found exhibited temperature-dependent sexually dimorphic expression, located medullary somatic cells early embryos red-eared slider turtle...
In the new stage of China’s economic transformation from high-speed growth to high-quality development, scientific and technological factors have become driving force for development economy. Therefore, how flow affects regional economy is worthy in-depth discussion. Based on panel data 30 provinces (municipalities districts) in China 2006 2019, this paper calculates index by constructing a comprehensive system, empirically examines direct effect, spatial effect threshold (including talent...
This study aims to explore the roles of three estrogen receptors (Esr1, Esr2, and Gper1) in early differentiation embryonic gonads
ABSTRACT Müllerian-inhibiting substance ( Mis , or anti-müllerian hormone, Amh ), a member of TGF-β superfamily, as initiator key regulator in sexual development has been well documented some vertebrates, especially fish. However, its functional role not identified yet reptiles. Here we characterized the gene Chinese soft-shelled turtle Pelodiscus sinensis (P. sinensis) typical reptilian species exhibiting ZZ/ZW sex chromosomes. The mRNA was initially expressed male embryonic gonads by stage...