A5052079298- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Hippo pathway signaling and YAP/TAZ
University of Massachusetts Boston
2021-2023
Color vision in Drosophila melanogaster is based on the expression of five different color-sensing Rhodopsin proteins distinct subtypes photoreceptor neurons. Promoter regions less than 300 base pairs are sufficient to reproduce unique, subtype-specific rhodopsin patterns. The underlying cis -regulatory logic remains poorly understood, but it has been proposed that promoters have a bipartite structure: distal promoter region directs highly restricted specific subtype, while proximal core...
During terminal differentiation of the mammalian retina, transcription factors control binary cell fate decisions that generate functionally distinct subtypes photoreceptor neurons. For instance, Otx2 and RORβ activate expression transcriptional repressor Blimp-1/PRDM1 represses bipolar interneuron promotes rod fate. Moreover, Crx promote nuclear receptor Nrl cone Mutations in these four cause severe eye diseases such as retinitis pigmentosa. Here, we show a post-mitotic decision Drosophila...