A5075237410- Neurobiology and Insect Physiology Research
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Glycogen Storage Diseases and Myoclonus
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
Columbia University
2022
University of Massachusetts Boston
2021
New York University
2015
The final identity and functional properties of a neuron are specified by terminal differentiation genes, which controlled specific motifs in compact regulatory regions. To determine how these sequences integrate inputs from transcription factors that specify cell types, we compared the mechanism Drosophila Rhodopsin genes expressed subsets photoreceptors to phototransduction broadly, all photoreceptors. Both sets share an 11-base pair (bp) activator motif. Broadly contain palindromic...
Color vision in Drosophila melanogaster is based on the expression of five different color-sensing Rhodopsin proteins distinct subtypes photoreceptor neurons. Promoter regions less than 300 base pairs are sufficient to reproduce unique, subtype-specific rhodopsin patterns. The underlying cis -regulatory logic remains poorly understood, but it has been proposed that promoters have a bipartite structure: distal promoter region directs highly restricted specific subtype, while proximal core...