A5051873304- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Bacterial Genetics and Biotechnology
- Spaceflight effects on biology
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Bone health and osteoporosis research
- Cancer Immunotherapy and Biomarkers
- Microbial Fuel Cells and Bioremediation
- Diabetes and associated disorders
- Bacterial biofilms and quorum sensing
- Metalloenzymes and iron-sulfur proteins
- SARS-CoV-2 and COVID-19 Research
- Wound Healing and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Genomics, phytochemicals, and oxidative stress
- Eicosanoids and Hypertension Pharmacology
- Laser Applications in Dentistry and Medicine
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Phytochemicals and Antioxidant Activities
- Dermatologic Treatments and Research
Bambino Gesù Children's Hospital
2023-2024
University of Siena
2020-2024
Istituto Pasteur
2017
Sapienza University of Rome
2017
ABSTRACT In Pseudomonas aeruginosa , the ferric uptake regulator (Fur) protein controls both metabolism and virulence in response to iron availability. Differently from other bacteria, attempts obtain fur deletion mutants of P. failed, leading assumption that Fur is an essential this bacterium. By investigating a conditional mutant, we demonstrate not for growth liquid media, biofilm formation, pathogenicity insect model infection. Conversely, on solid media since Fur-depleted cells are...
Abstract Insufficient vessel maintenance adversely impacts patients in terms of tissue reperfusion following stroke or myocardial infarction, as well during wound healing. Angiogenesis impairment is a feature typical metabolic disorders acting at the cardiovascular level, such diabetes. Therapeutic angiogenesis regulation offers promising clinical implications, and natural compounds pro‐angiogenic nutraceuticals hold valuable applications regenerative medicine. By using cultured endothelial...
The fine control of inflammation following injury avoids fibrotic scars or impaired wounds. Due to side effects by anti-inflammatory drugs, the research is continuously active define alternative therapies. Among them, physical countermeasures such as photobiomodulation therapy (PBMT) are considered effective and safe. To study cellular molecular events associated with activity PBMT a dual-wavelength NIR laser source, human dermal fibroblasts were exposed mix inflammatory cytokines (IL-1β...
Optimal immune function is crucial in preventing cancer development and growth for the success of anti-cancer therapies. Here, we characterized peripheral immunological status 83 steroids-naïve pediatric patients with central nervous system neoplasia at disease onset. Tumors were classified into low-grade gliomas (LGG), high-grade (HGG), medulloblastoma, other tumors. We revealed that glioma showed an altered lymphocyte pool. T-cells HGG shifted from naïve to effector memory phenotype. LGG...
Mucosal-associated invariant T (MAIT) cells are innate-like implicated in the response to fungal and bacterial infections. Their contribution restoring T-cell immunity influencing hematopoietic stem cell transplant (HSCT) outcomes remains poorly understood. We retrospectively studied MAIT-cell recovery 145 consecutive children young adults with hematologic malignancies undergoing allogeneic (allo)-HSCT between April 2019 May 2022, from unrelated matched donor (MUD, N=52), standard...
Abstract Pediatric central nervous system (CNS) tumors are the most common solid tumor in children. Despite improvements diagnostic and therapeutic approaches over time, treatment effectiveness remains unsatisfactory. Optimal immune function is critical to protect against development dissemination of cancer offer ideal conditions for success anticancer treatment. Here we analyzed peripheral immunological features patients affected by pediatric brain tumors, process de novo T- B-cell its...
ABSTRACT Iron-sulfur [Fe-S] clusters are essential protein cofactors allowing bacteria to perceive environmental redox modification and adapt iron limitation. Escherichia coli , which served as a bacterial model, contains two cluster biogenesis systems, ISC SUF, ensure synthesis under balanced stress conditions, respectively. However, our recent phylogenomic analyses revealed that most possess only one system, often SUF. The opportunist human pathogen Pseudomonas aeruginosa is atypical it...