Learning and behavioral abnormalities are among the most common clinical problems in children with neurofibromatosis-1 (NF1) inherited cancer syndrome. Recent studies using Nf1 genetically engineered mice (GEM) have been instructive for partly elucidating cellular molecular defects underlying these cognitive deficits; however, no current model has shed light on more frequently encountered attention system seen NF1. Using an optic glioma (OPG) GEM model, we report novel non-selective...

Whereas carcinogenesis requires the acquisition of driver mutations in progenitor cells, tumor growth and progression are heavily influenced by local microenvironment. Previous studies from our laboratory have used Neurofibromatosis-1 (NF1) genetically engineered mice to characterize role stromal cells signals optic glioma formation growth. Previously, we shown that Nf1+/- microglia microenvironment critical cellular determinants proliferation. To define maintenance further, CD11b-TK mice,...

Recent studies have shown that neuroglial progenitor/stem cells (NSCs) from different brain regions exhibit varying capacities for self-renewal and differentiation. In this study, we used neurofibromatosis-1 (NF1) as a model system to elucidate novel molecular mechanism underlying region-specific NSC functional heterogeneity. We demonstrate Nf1 loss leads increased proliferation gliogenesis in the brainstem, but not cortex. Using genetically engineered mice derivative neurosphere cultures,...

The high mobility group factor NUPR1, also known as p8 and com1, plays a role in temporal expression of the beta subunit luteinizing hormone, LHB, during gonadotroph development. At Embryonic Day (e) 16.5, LHB is detectable wild-type (Nupr1(+/+)) but not Nupr1 knockout (Nupr1(-/-)) mice. initiated by e17.5 Nupr1(-/-) mice, fully recovered Postnatal (p) 2. Factors indicative pituitary maturation, GATA2, CGA, TSH, are differentially expressed Nupr1(+/+) embryos at e17.5. Therefore, delay does...

Recent data published by the Special Operations community suggest Lethal Triad of Trauma should be changed to Diamond, include coagulopathy, acidosis, hypothermia, and hypocalcemia. The purpose this study is determine prevalence trauma-induced hypocalcemia in level I II trauma patients.This a retrospective cohort conducted at center Combat Medic (SOCM) training site. Adult patients were identified via services registry from September 2021 April 2022. Patients who received blood products...

Abstract A recent publication described pathological findings in the pituitary gland incidentally discovered during routine necropsies of brain dogs and cats; however, imaging characteristics these lesions were not reported. Aims this retrospective, observational study to characterize MRI variants incidental glands with no clinical signs disease. Cranial MRIs from suspicion disease, based on history presenting signs, retrieved a veterinary teleradiology database period January 2014 2016....

Several published studies have described the success and satisfaction of residents enrolled in human radiology training programs, however comparable for veterinary are currently lacking. The purpose this descriptive, survey study was to evaluate resident perceptions European College Veterinary Diagnostic Imaging (ECVDI) residency programs. A web-based sent all listed 114 ECVDI received a 57.0% response (65/114). Of these, 88% respondents enjoyed their 73.5% finishing agreed they felt ready...

Case summary A 2-year-old male domestic shorthair cat presented to the University of Liverpool Small Animal Teaching Hospital with a 2 week history altered mentation, blindness and focal epileptic seizures. MRI examination revealed generalised cerebral cerebellar atrophy, diffuse T2-weighted hyperintensity white matter meningeal thickening. Neuronal ceroid lipofuscinosis was confirmed on post-mortem examination. Relevance novel information This is first report findings neuronal in cat.

Collaborative Care as an Effective Intervention for Primary Patients at Risk Suicide Virna Little, PsyD, LCSW-R, SAP, CCM and Crystal White, MSW In the United States, suicide is 10th leading cause of death with more than 47,000 deaths by estimated 1.4 million attempts annually. comparable to other causes death, including diabetes, heart disease, stroke (AFSP, 2019). Approximately 45% people who die visit a primary care provider (PCP) 30 days before their death. —JB Luoma, et al. 20021 Most...

Objectives To describe the computed tomographic (CT) findings of gastric malposition in a group dogs with suspected chronic instability. Materials and Methods A multicentre retrospective study CT studies abnormal position absence clinical signs referable to dilatation volvulus. Results Gastric was identified six as either an incidental finding or histories intermittent gastroenteropathy. similar all cases; pyloric canal positioned left cranial abdomen close proximity cardia antrum found...

A 3-year-old female entire whippet presented for non-ambulatory paraparesis, approximately 5 hours after an unwitnessed trauma. On examination, the dog had stable cardiovascular parameters and mild tachypnoea with normal thoracic auscultation. Neurological examination localised lesion to T3-L3 spinal cord segments. non-contrast CT confirmed a T12-13 subluxation multiple small vertebral chip fractures bilateral pneumothorax. In cranioventral aspect of right caudal lung lobe was well-defined...

Ultrasound-guided fine-needle aspirates (FNA) of the liver and spleen for cytological analysis are a commonly performed procedure in canine veterinary practice. Based on our review literature, this is first published study investigating whether needle size affects diagnostic quality hepatic splenic samples. The aim prospective analytical was to compare ultrasound-guided FNA samples based cellularity, blood contamination, overall cell preservation between three different sizes (22-, 23-,...

The high mobility group factor p8 plays a role in temporal expression of LHβ during gonadotrope development. At embryonic day (e) 16.5, time when is detectable wild-type (WT) mice, it not knockout (p8-KO) mice. Expression initiated by e17.5 these mice and fully recovered postnatal (p) 2. Factors important for differentiation maturation, Gata2 αGSU, are differentially expressed p8-KO WT embryos at e17.5; neither the thyrotrope-specific TSHβ. Therefore, delay gonadotropes does appear to result...

The General Medical Council has fleshed out its advice to all registered doctors on new requirements comply with proposed changes the system of registration. Revalidation — five yearly requirement retain a licence will depend satisfactory completion annual appraisals, which are soon become common practice in NHS, or other documentary evidence that fulfils seven GMC's principles good medical practice. The changes, outlined A Licence Practice and Revalidation , is published last week, …