A5027230520- Veterinary Orthopedics and Neurology
- Spinal Dysraphism and Malformations
- Veterinary Oncology Research
- Head and Neck Surgical Oncology
- Epilepsy research and treatment
- Spine and Intervertebral Disc Pathology
- Cerebrospinal fluid and hydrocephalus
- Neurological diseases and metabolism
- Bacterial Infections and Vaccines
- Hearing, Cochlea, Tinnitus, Genetics
- Infectious Encephalopathies and Encephalitis
- Neonatal and fetal brain pathology
- Cervical and Thoracic Myelopathy
- Metabolism and Genetic Disorders
- Craniofacial Disorders and Treatments
- Veterinary Equine Medical Research
- Infectious Diseases and Tuberculosis
- Pharmacological Effects and Toxicity Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Neuroscience of respiration and sleep
- Glycogen Storage Diseases and Myoclonus
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Animal health and immunology
University of Liverpool
2016-2025
Unidade Hospitalar de Bragança
2024
King's College London
2016
Centro Cardiologico Monzino
2016
Institute of Experimental Cardiology
2016
Imperial College London
2016
University of Florence
2016
Hospital de Dona Estefânia
2015
Hospital Dr. Nélio Mendonça
2014
University of Glasgow
2008-2012
Abstract Background Meningoencephalitis of unknown origin (MUO) comprises a group noninfectious inflammatory diseases affecting the central nervous system dogs. Previous studies have reported individual risk factors for survival but prognostication MUO remains challenging. Objectives Identify clinical prognostic variables in dogs with MUO. Animals A retrospective study 447 presented to 2 UK referral hospitals and diagnosed Methods Medical records were retrospectively reviewed. Multivariable...
The epidemiology of inflammatory diseases affecting the central nervous system (CNS) in dogs is largely unknown. We aimed to report relative proportion different causes disease CNS and identify predictors for infectious vs. immune-mediated conditions most common brain spinal cord. This was a retrospective cohort study over 10-year period 2 referral institutions using multivariable multinomial logistic regression identification risk factors. In total, 1,140 client-owned diagnosed with were...
Canine meningoencephalitis of unknown origin (MUO) is a debilitating disease associated with high mortality. The prognostic value magnetic resonance imaging (MRI) findings for predicting survival at 12 months and long-term relapse remains uncertain.
The aetiology and outcome of dogs with juvenile‐onset seizures were investigated. One hundred thirty‐six whose first seizure occurred before the age one year two diagnosed idiopathic epilepsy (IE), 23 symptomatic (SE), nine reactive (RS) probable (pSE). was known in 114 dogs; 37 per cent died or euthanased as a consequence seizures. mean survival time this population 7.1 years. Factors that significantly associated included diagnosis SE number antiepileptic drugs (AEDs) used investigation....
Meningoencephalitis of unknown origin (MUO) comprises a group debilitating inflammatory diseases affecting the central nervous system dogs. Currently, no validated clinical scale is available for objective assessment MUO severity.Design neurodisability (NDS) to grade severity and determine its reliability whether or not score at presentation correlates with outcome.One hundred dogs were included retrospective review 31 subsequently enrolled prospective evaluation.Medical records...
Epilepsy is one of the most common chronic neurological conditions affecting dogs. Previous research exploring likelihood a structural cause epilepsy specifically in dogs with normal inter-ictal examination limited to small population using low-field MRI. The aims this study were establish high-field (1.0T and 1.5T) MRI findings presenting epileptic seizures examination. Medical records retrospectively searched for at least two seizure events more than 24 h apart. To be included study,...
The diagnosis of discospondylitis is based mainly on diagnostic imaging and laboratory results. Herein, we describe the magnetic resonance (MRI) findings in 13 dogs with confirmed discospondylitis. In total there were 17 sites Eleven (81.1%) had spinal pain for >3 weeks a variable degree neurologic signs. Two ataxia 4 days. Radiographs available nine dogs. MR images was always involvement two adjacent vertebral endplates associated disk. involved marrow T1-hypointense hyperintensity short...
To characterise the clinical presentation and neurological abnormalities in dogs affected by aortic thromboembolism.The medical records of 13 diagnosed with thromboembolism as cause signs, where a complete examination was performed, were reviewed retrospectively.The onset acute only four dogs, chronic five (with all these presenting exercise intolerance) or deterioration dogs. Dogs an signs more severely exhibiting deficits, while disease predominantly presented intolerance minimal deficits....
Medical records of 92 cats presented with clinical signs spinal cord disease, which had undergone magnetic resonance imaging (MRI), were reviewed. The grouped into seven categories based upon the diagnosis suggested by results MRI, cerebrospinal fluid analysis and other diagnostic procedures: neoplastic (n=25), inflammatory or infectious (n=13), traumatic (n=8), vascular (n=6), degenerative (n=5), anomalous (n=3) those an unremarkable MRI (n=32). There two independent predictors abnormal...
Abstract Background The pathophysiology of changes in magnetic resonance imaging (MRI) detected after a seizure is not fully understood. Objective To characterize and describe seizure‐induced by MRI. Animals Eighty‐one client‐owned dogs diagnosed with idiopathic epilepsy. Methods Data collected retrospectively from medical records included anatomical areas affected, T1‐, T2‐weighted T2‐FLAIR (fluid‐attenuated inversion recovery) appearance, whether were unilateral or bilateral, symmetry,...
OPINION article Front. Vet. Sci., 05 October 2023Sec. Veterinary Neurology and Neurosurgery Volume 10 - 2023 | https://doi.org/10.3389/fvets.2023.1272755
Infratentorial tumors are relatively infrequent in dogs and a lack of data makes it difficult to offer prognostic information. Untreated, with these neoplasms have shorter survival times than those supratentorial tumors. The role radiation therapy (RT) the management infratentorial is poorly defined tumoral/peritumoral swelling this site potential cause serious acute side effects. aim retrospective, cohort study was describe cases treated fractionated three-dimensional conformal RT (3D CRT)...
To review the clinical findings and outcome in dogs diagnosed with insulinoma, to assess which factors are predictors of overall survival. Additionally, describe neurological manifestations this population their correlation survival.Retrospective multicentric study canine insulinoma cases (2009 2020). Signalment, history, examination, diagnostic findings, treatment were obtained from records. Univariate multivariate analyses used compare survival.One hundred sixteen included. Median duration...
Metabolic/neurodegenerative encephalopathies encompass a wide list of conditions that share similar clinical and magnetic resonance imaging (MRI) characteristics, challenging the diagnostic process resulting in numerous tests performed order to reach definitive diagnosis. The aims this multicentric, retrospective descriptive study are: (I) describe MRI features dogs cats with metabolic/neurodegenerative encephalopathies; (II) attempt an recognition pattern classifying these according...
Spondylosis deformans and diffuse idiopathic skeletal hyperostosis ( DISH ) are usually incidental findings in most dogs either asymptomatic or associated with mild clinical signs. Severe spondylosis can result complete bony fusion of consecutive vertebral segments. One the recognised complications following human patients is development adjacent segment disease, which defined as degenerative changes, commonly intervertebral disc mobile neighboring a region fusion. A similar syndrome...
For accurate interpretation of magnetic resonance (MR) images the equine brain, knowledge normal cross‐sectional anatomy brain and associated structures (such as cranial nerves) is essential. The purpose this prospective cadaver study was to describe compare MRI computed tomography (CT) nerves' origins skull foramina in a sample five horses. All horses were presented for euthanasia reasons unrelated head. Heads collected posteuthanasia T2‐weighted MR obtained transverse, sagittal, dorsal...
Background Corpus callosal abnormalities ( CCA ) in dogs have been only sporadically reported and are poorly characterized. Hypothesis/Objectives To describe the clinical presentation magnetic resonance imaging MRI characteristics of with . Animals Fifteen client‐owned dogs. Methods Retrospective study. Records contributing institutions were reviewed to identify diagnosed malformations affecting corpus callosum CC ); cases which was thought be secondary excluded. Results The most represented...
Background The term meningoencephalocele ( MEC ) describes a herniation of cerebral tissue and meninges through defect in the cranium, whereas meningocele MC is alone. Hypothesis/Objectives To describe clinical features, magnetic resonance imaging MRI characteristics, outcomes dogs with cranial . Animals Twenty‐two client‐owned diagnosed or Methods Multicentric retrospective descriptive study. Clinical records 13 institutions were reviewed. Signalment, history, neurologic findings...
Abstract Background This study aimed to identify complications associated with cerebrospinal fluid (CSF) collection in dogs. Methods was a prospective, observational multicentre using data collected from 102 dogs undergoing CSF for the investigation of neurological disease. cerebellomedullary cistern (CMC), lumbar subarachnoid space (LSAS) or both sites. Pre‐, intra‐ and postprocedural were collected. Descriptive statistics performed outline collection. Results sampling attempted on 108...
Although idiopathic episodic head tremor (IEHT) in dogs is well-known, little known about structural brain lesions causing (SEHT).Describe semiology, magnetic resonance imaging (MRI) findings and outcome of with IEHT or SEHT. We hypothesized that affecting the middle cranial fossa mesencephalic aqueduct could lead to SEHT.One hundred (n = 71) SEHT 29).Retrospective, multicenter, study (nonintentional) MRI between 2004 2022.Lesions on were localized (15/29), cerebrocortex (3/29), brainstem...
Idiopathic facial neuropathy in dogs is conventionally diagnosed by exclusion of structural and metabolic causes a single cranial neuropathy. To investigate the reliability validity MRI for supporting diagnosis dogs, we examined MR images brainstem from 20 with presumed idiopathic neuropathy, control dogs. Two different types sequence were compared: volumetric interpolated breath-hold examination (VIBE-MRI), conventional T1-weighted MRI. Three independent observers, blinded to case details,...
The aim of the present study was to retrospectively evaluate clinical signs, MRI characteristics, interobserver agreement and outcome after medical treatment in dogs affected by cervical intervertebral foraminal disc extrusion (CIFDE). records three referral institutions were searched for diagnosed with CIFDE between 2010 2012. Thirteen identified CIFDE; often had a normal neurological examination, hyperaesthesia lameness as most common signs. On MRI, sagittal images showed no evidence...
Abstract Background Vestibular dysfunction is relatively common in dogs, with a prevalence of 0.08% reported primary veterinary care the UK. There are several studies investigating how to differentiate between peripheral and central vestibular disease but only limited information regarding possible underlying causes for dogs. This study therefore aimed describe clinical signs, magnetic resonance imaging findings (MRI), outcome large population dogs diagnosed disease. Results One hundred...