Bone is removed or replaced in defined locations by targeting osteoclasts and osteoblasts response to its local history of mechanical loading. There increasing evidence that osteocytes modulate this their apoptosis, which associated with locally increased bone resorption. To investigate the role control loading-related modeling remodeling, we studied effects on osteocyte viability short periods loading applied ulnae rats. Loading, produced peak compressive strains −0.003 −0.004, was a 78%...

Abstract Previous studies have indicated that physiological levels of dynamic mechanical strain produce rapid increases in nitric oxide (NO) release from rat ulna explants and primary cultures osteoblast-like cells embryonic chick osteocytes derived long bones. To establish the mechanism by which loading-induced NO production may be regulated, we examined: synthase (NOS) isoform mRNA protein expression, effect loading vivo on NOS bone culture. Using Northern blot analyses, situ...

Abstract Responses to mechanical strain in calvaria and limb bone organ cultures were compared by measuring cellular glucose 6-phosphate dehydrogenase (G6PD) activity situ prostaglandin release. Normal functional strains recorded the ulnae (1000 μϵ) calvarium (30 vivo 110 g rats. Organ of from similar animals loaded produce dynamic (600 cycles, 1 Hz) 1000 μϵ ulna, 100 or calvaria. In ulnae, both PGE2 PGI2 released resident osteocytes osteoblasts showed increased G6PD activity. Neither...

Abstract The presence of estrogen receptor α (ERα) in osteocytes was identified immunocytochemically transverse sections from 560 to 860 μm distal the midshaft normal neonatal and adult male female rat ulnas ( n = 3 each) that had been exposed 10 days vivo daily 10‐minute periods cyclic loading producing peak strains either −3000 3) or −4000 microstrain 5). Each animal ambulated normally between periods, its contralateral ulna used as a control. In animals which limbs were subject locomotor...

To characterise the clinical presentation and neurological abnormalities in dogs affected by aortic thromboembolism.The medical records of 13 diagnosed with thromboembolism as cause signs, where a complete examination was performed, were reviewed retrospectively.The onset acute only four dogs, chronic five (with all these presenting exercise intolerance) or deterioration dogs. Dogs an signs more severely exhibiting deficits, while disease predominantly presented intolerance minimal deficits....

A uniform and adherent layer of β-UD3 was formed on uranium when reacted with deuterium in the temperature range 175–350°C pressure 100–10 270 torr. The rate reaction controlled by diffusion across this product layer. Reproducible results were obtained only D2 very high purity because low-level impurities had a profound effect reaction. It concluded that molecular sorption predominant method mass transport, but atomic may also be occurring. activation energy for Langmuir UD3 determined to...

Abstract A number of early biochemical responses bone cells to mechanical loading have been identified, but the full sequence events from sensing strain formation new is poorly characterized. Extracellular matrix proteins can modulate cell behavior and would be ideal molecules amplify response loading. The extracellular protein, tenascin-C, supports differentiation cultured osteoblast-like cells. current study was carried out investigate whether expression patterns tenascin-C in loaded bones...

To characterise the presenting signs and pathological changes of canine bacterial infective arthritis in 31 dogs, to document response different treatment regimens. Risk factors that may predispose joints influence success were also investigated.A retrospective review cases presented three university veterinary referral hospitals over a five-year period (January 1997 January 2002) was performed.The elbow joint (38 per cent) stifle (44 most commonly affected. Radiographic consistent with...

Intravesical BCG-instillation for bladder cancer is considered safe but not without risk. While most side-effects are localised and self-limiting, the development of secondary vascular pathology a rare significant complication.A 77-year-old male presented with mycotic abdominal aortic aneurysm associated aorto-enteric fistula 18 months after receiving intravesical BCG-instillations early stage transitional cell carcinoma.Response rates to BCG carcinoma high. The procedure produces...

Abstract Bone's functional competence is established and maintained, at least partly, by mechanisms involving appropriate adaptation to mechanical loading. These appear fail in chickens selectively bred either for maximum egg (Egg-type) or meat (Meat-type) production, which show high rates of fracture skeletal abnormality, respectively. By measuring several early strain-induced responses cultured embryonic tibiotarsi from commercially (Egg-type Meat-type) wild-type (Wild-type) chicks, we...

This study evaluated the feasibility, complications and long-term outcomes of using a cannulated drill system combined with intraoperative imaging to place transcondylar screw for management canine humeral intracondylar fissure. Thirteen dogs were enrolled, one dog undergoing staged bilateral surgery. No occurred. Five minor (36%) three major (21%) postoperative occurred, giving an overall complication rate 57%. None screws placed penetrated articular surface. The mean duration surgery was...

Cranial cruciate ligament (CCL) rupture is one of the most important orthopedic diseases taught to veterinary undergraduates. The complexity anatomy canine stifle joint combined with plethora different surgical interventions available for treatment disease means that undergraduate students often have a poor understanding pathophysiology and CCL rupture. We designed, developed, tested three dimensional (3D) animation illustrate pertinent clinical joint, effects rupture, mechanisms by which...

Abstract OBJECTIVE To investigate in vitro effects of triclosan coating suture materials on the growth clinically relevant bacteria isolated from wounds dogs. SAMPLE 6 types material and 10 isolates each methicillin-susceptible Staphylococcus pseudintermedius , methicillin-resistant S Escherichia coli AmpC β-lactamase extended-spectrum β-lactamase–producing E clinical wound infections. PROCEDURES Isolates were cultured Mueller-Hinton agar with 3 triclosan-coated suture, uncoated counterparts...

The medical records of dogs receiving surgery for unilateral patellar ligament rupture between 1999 and 2012 at 12 multidisciplinary referral centres were reviewed. Forty-three cases identified; 26 traumatic in origin; almost one-third iatrogenic, which over three-quarters occurred as a complication following surgical stabilisation luxation. Treatment involved primary reapposition the (36 cases). repair was protected by circumpatellar and/or transpatellar loop(s) orthopaedic wire, nylon,...

Summary Objectives: Since external coaptation is applied clinically to prevent plate failure during healing in canine pancarpal arthrodesis (PCA), we tested the hypothesis that does not significantly reduce strain an experimental ex vivo model of PCA. Methods: Ten thoracic limbs from healthy Greyhounds euthanatized for reasons un- related study were harvested and carpus was stabilised with a dorsally 2.7/3.5 mm hybrid PCA plate. The adjacent most distal radial screw hole (R4) carpal bone...

The medical records of cats receiving surgical treatment for unilateral patellar ligament rupture between 1999 and 2012 at 12 referral centres in the UK Ireland were reviewed. Seven cases identified: six caused by trauma one was iatrogenic, occurring as a complication following stabilisation tibial fracture. All treated sutured anastomosis ruptured ligament, with repairs protected circumpatellar and/or transpatellar loop suture. stifle immobilised transarticular external skeletal fixation...