A5046908572- Muscle Physiology and Disorders
- Cerebrospinal fluid and hydrocephalus
- Cardiomyopathy and Myosin Studies
- Veterinary Oncology Research
- Head and Neck Surgical Oncology
- Bacterial Infections and Vaccines
- Metabolism and Genetic Disorders
- Infectious Encephalopathies and Encephalitis
- Facial Nerve Paralysis Treatment and Research
- Neurogenetic and Muscular Disorders Research
- Pancreatic function and diabetes
- Animal health and immunology
- Child Nutrition and Water Access
- Diverticular Disease and Complications
- Spinal Dysraphism and Malformations
- Fetal and Pediatric Neurological Disorders
- Traumatic Ocular and Foreign Body Injuries
- Veterinary Orthopedics and Neurology
- Magnesium in Health and Disease
- Metabolomics and Mass Spectrometry Studies
- Spinal Hematomas and Complications
- Epilepsy research and treatment
- Teratomas and Epidermoid Cysts
- Coccidia and coccidiosis research
- Veterinary Medicine and Surgery
University of Liverpool
2015-2024
Western Sydney University
2019-2020
Royal Veterinary College
2006-2016
University of Cambridge
2005-2006
Howard College
2006
University of Leeds
1975-1977
Leeds General Infirmary
1975
Abstract Background Meningoencephalitis of unknown origin (MUO) comprises a group noninfectious inflammatory diseases affecting the central nervous system dogs. Previous studies have reported individual risk factors for survival but prognostication MUO remains challenging. Objectives Identify clinical prognostic variables in dogs with MUO. Animals A retrospective study 447 presented to 2 UK referral hospitals and diagnosed Methods Medical records were retrospectively reviewed. Multivariable...
Duchenne muscular dystrophy (DMD), which afflicts 1 in 3500 boys, is one of the most common genetic disorders children. This fatal degenerative condition caused by an absence or deficiency dystrophin striated muscle. Most affected patients have inherited spontaneous deletions gene that disrupt reading frame resulting unstable truncated products. For these patients, restoration via antisense oligonucleotide-mediated exon skipping a promising therapeutic approach. The major DMD deletion "hot...
A simple system has been developed to identify patients with upper gastrointestinal tract haemorrhage who run a high risk of continued bleeding or rebleeding. The is based on six items patient data available at soon after arrival in hospital. It was evaluated prospective study 66 haemorrhage. Over half the classified by into high-risk category either rebled apparent cessation (as against one out 33 low-risk category). high-rish group also had higher mortality (21%) than those (nil). addition...
The epidemiology of inflammatory diseases affecting the central nervous system (CNS) in dogs is largely unknown. We aimed to report relative proportion different causes disease CNS and identify predictors for infectious vs. immune-mediated conditions most common brain spinal cord. This was a retrospective cohort study over 10-year period 2 referral institutions using multivariable multinomial logistic regression identification risk factors. In total, 1,140 client-owned diagnosed with were...
Canine meningoencephalitis of unknown origin (MUO) is a debilitating disease associated with high mortality. The prognostic value magnetic resonance imaging (MRI) findings for predicting survival at 12 months and long-term relapse remains uncertain.
Meningoencephalitis of unknown origin (MUO) comprises a group debilitating inflammatory diseases affecting the central nervous system dogs. Currently, no validated clinical scale is available for objective assessment MUO severity.Design neurodisability (NDS) to grade severity and determine its reliability whether or not score at presentation correlates with outcome.One hundred dogs were included retrospective review 31 subsequently enrolled prospective evaluation.Medical records...
The reduced diameter of skeletal myofibres is a hallmark several congenital myopathies, yet the underlying cellular and molecular mechanisms remain elusive. In this study, we investigate role HACD1/PTPLA, which involved in elongation very long chain fatty acids, muscle fibre formation. humans dogs, HACD1 deficiency leads to myopathy with size disproportion associated generalized weakness. Through analysis HACD1-deficient Labradors, Hacd1-knockout mice, Hacd1-deficient myoblasts, provide...
The molecular identity of platelet Ca(2+) entry pathways is controversial. Furthermore, the extent to which Ca(2+)-permeable ion channels are functional in these tiny, anucleate cells difficult assess by direct electrophysiological measurements. Recent work has highlighted how primary megakaryocyte represents a bona fide surrogate for studies signalling, including patch clamp recordings ionic conductances. We have now screened all known members transient receptor potential (TRP) family...
A nine-month-old puppy was presented for investigation of seizures. Neurological deficits were found localising to the prosencephalon, mesencephalon and myelencephalon. Magnetic resonance imaging identified multiple, large lesions involving both cerebral hemispheres. Management with antiepileptic immunomodulatory drugs instituted; however, seizures became progressively refractory euthanased. Histopathology following post-mortem examination a mixed glial cell tumour discrete areas where...
Intramedullary masses are a dilemma due to the limited access for nonsurgical biopsy, thus, accurate imaging characterization is crucial. Magnetic resonance findings of two confirmed canine thoracic intramedullary hemangiomas described. A capillary hemangioma was mixed intensity but predominantly T2‐hyperintense and mildly T1‐hyperintense spinal cord with strong contrast enhancement. cavernous had target‐like appearance in both T1‐weighted (T1w) T2‐weighted (T2w) images. In T2w images there...
Feline tail pull injury is a challenging condition that commonly encountered in first‐opinion practice. This article discusses the key factors diagnosis, prognosis and management of injuries, including use radiography to confirm sacrocaudal luxation, identification appropriate treatment associated urinary faecal dysfunction. It also highlights importance good owner communication, as currently best prognostic indicators at time presentation for return continence (the conscious perception...
A five-year eight-month-old Maltese terrier was presented with a 3-week history of progressive paraparesis and pelvic limb ataxia. Neurological examination consistent lesion involving the T3-L3 spinal cord segments. Myelogram magnetic resonance imaging revealed spherical, intradural-extramedullary mass at T13/L1. dorsal laminectomy, durotomy debulking were performed. Histopathologic highly cellular tissue, most likely mesenchymal origin, infiltrated by many lymphocytes, macrophages...
To evaluate whether concurrent analysis of CSF samples from 2 collection sites (cerebellomedullary cistern [CMC] and lumbar subarachnoid space [LSS]) versus only 1 site could improve the diagnostic sensitivity for dogs with suspected steroid-responsive meningitis arteritis (SRMA).111 client-owned SRMA diagnosed at 3 veterinary referral hospitals between 2011 2017.Only collected both (CMC LSS) no previous history corticosteroid administration were included. Medical record data logistic...
A 3-year-old male neutered domestic shorthair cat was presented with a 1-week progressive and rapidly deteriorating history of lethargy abnormal behaviour. Neurolocalisation indicated multifocal intracranial lesions (right oculomotor nerve, brainstem [obtundation, non-ambulatory tetraparesis, vestibular dysfunction intermittent decerebrate rigidity] possibly the thalamus [left-sided pleurothotonus]), or more likely single lesion mass effect. MRI brain demonstrated abscess causing severe...
Summary A variety of clinical disorders caused by the foreign body reaction to migrating plant material have been reported in dog. In this report, we describe a novel presentation an adult dog which condition produced signs progressive thoracic limb lameness and cervical spinal pain, mimicking tumour brachial plexus.
A two-stage questionnaire which the patient completes at home has been developed for use by gynaecological outpatients. The first stage (root) identifies patient's problem and obtains general background information. second (branch) deals with presenting in depth. system proved highly acceptable to patients. At clinic a non-medical assistant uses programmed typewriter transcribe data into typewritten history is handed doctor before he examines patient. transcript compares favourably...
This qualitative study explores the ideas and experiences of interprofessional collaboration (IPC) among health professionals in rural public hospitals to propagate its normalization into practice by identifying existing or suggested solutions. The literature focuses largely on barriers facilitators IPC metropolitan areas there is room identify more practical responses for implementing Semi-structured interviews were conducted with 13 healthcare (October 2018-March 2019). Interviews...