A5073564390- Chemical Synthesis and Analysis
- Catalytic Cross-Coupling Reactions
- Smoking Behavior and Cessation
- Organoboron and organosilicon chemistry
- Obesity, Physical Activity, Diet
- Global Public Health Policies and Epidemiology
Chestnut Hill College
2020
Boston College
2020
We disclose a method for sequential Conia-ene-type cyclization/Negishi coupling the union of alkynyl ketones and aryl iodides. This process is promoted through cooperative actions Lewis acidic B(C6F5)3, ZnI2, Pd-based complex, Brønsted basic amine. The three acid catalysts with potential overlapping functions play their independent roles as activators carbonyl group, alkyne moiety, alkenyl zinc intermediate, respectively. A variety 1,2,3-substituted cyclopentenes can be synthesized high efficiency.
Use of electronic cigarettes has increased across the world in last decade with heavy investment from tobacco industry targeting younger population through well-designed marketing campaigns portraying e-cigarettes as harmless, less addictive and effective smoking cessation while delivering higher nicotine concentration. The safety profile is reviewed this paper.The chemicals they contain have not been evaluated rigorously. Emerging data suggest e-cigarette use could do severe harm. People...