A5062424092- Blood groups and transfusion
- Multiple Myeloma Research and Treatments
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood disorders and treatments
- Blood donation and transfusion practices
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Trauma and Emergency Care Studies
- Engineering Technology and Methodologies
- Cyclone Separators and Fluid Dynamics
- Chronic Lymphocytic Leukemia Research
- Hemoglobinopathies and Related Disorders
- Cancer Treatment and Pharmacology
- Coal Combustion and Slurry Processing
- Kruppel-like factors research
- Material Properties and Applications
- Heat Transfer and Boiling Studies
- Medical and Biological Sciences
- Neutropenia and Cancer Infections
Russian Research Institute of Hematology and Transfusiology
2016-2022
Federal Medical-Biological Agency
2016-2022
Kirov Research Institute of Hematology and Blood Transfusion FMBA
2016-2020
Ophthalmology Clinic
2019
Research Center of Neurology
2017
Laboratory Imaging (Czechia)
2017
Neurological Surgery
2017
A criterion of the quality fresh frozen blood plasma (FFP) is activity clotting factor VIII (FVIII). Aim — to identify technological barriers in study FVIII thermolability and describe requirements for experiments, providing new knowledge about this factor. Basic information . An analysis domestic foreign publications devoted mechanisms responsible reducing value donor from moment donation transfusion was carried out. Data on decrease at various stages work with are presented. methods...
Aim. To determine the incidence of viral, bacterial, and fungal infections in post-transplant period to assess prognostic value their influence on early long-term results haploidentical hematopoietic stem cells transplantation (haplo-HSCT). Materials & Methods. Retrospective study included 61 patients older than 18 years with high-risk oncohematological diseases. In from 2015 2018 all received haplo-HSCT. Median follow-up after haplo-HSCT was 12.5 months (376 days, range 6-1202)....
The article is dedicated to administration of human intravenous immunoglobulin for patients with different pathology accompanied by immunity disorders. Pharmacokinetics and mechanisms its action are presented in detail. Capabilities use as replacement (in immunodeficiencies, agammaglobulinemia) immunomodulatory therapy autoimmune disorders) discussed. We present algorithms correction treatment lymphoproliferative diseases (such chronic lymphocytic leukemia, non-Hodgkin lymphoma, multiple...
Background. Myelofibrosis (primary myelofibrosis, postessential trombocythemia post-polycythemia myelofibrosis) is the most complex and pressing problem among all Ph-negative myeloproliferative diseases. The present article summarizes author's experience of using new Janus kinase inhibitors in routine clinical practice, compares data with results other research. Aim. To evaluate use ruxolitinib patients myelofibrosis. Materials & Methods. Our analysis includes 48 (21 men 27 women)...
Background & Aims. The use of thrombopoietin receptor agonists (aTPO-r) is a new approach to the treatment patients with idiopathic thrompocytopenic purpura (ITP) irresponsive other methods. Data on efficacy and safety aTPO-r outside frames clinical trials are limited. aim study evaluate therapy in routine practice as second subsequent lines therapy, well frequency nature complications chronic ITP patients. Methods. 58 adult (median age: 56 years) were retrospectively evaluated; 43 (74...
Detection of FLT3 gene mutations in acute myeloid leukemia is now recognized as an unfavorable factor that affects the disease course, emerging risk relapses and overall survival shortening disease-free patients. The aim study was to determine frequency assess their impact on clinical indicators, patients with leukemia. We compared complete blood count parameters, karyotype, duration 199 depending presence or absence gene. Significant differences across these groups were discovered only WBC...
Anemia is considered one of the manifistations many neoplasms affecting overall survival and reducing quality life patients. The prevalence anemia varies from 20 to 90% depending on nosology, stage disease, antitumor treatment. pathogenesis in cancer patients complex. Among pathogenetic factors, such factors are distinguished as tumor infiltration bone marrow by malignant cells, inhibition erythroid growth cytokines inflammation, decreased sensitivity receptors erythropoietin its production,...
Российский НИИ гематологии и трансфузиологии ФМБА 191024, Санкт-Петербург, ул. 2-я Советская, 16 В статье представлены результаты криоконсервирования эритроцитов при температурах -40 о С -80 С. Отмечена значительно более высокая сохранность функциональная полноценность эритроцитов, декриоконсервированных после хранения в течение 2-5-ти месяцев объеме стандартной дозы температуре С, отличие от По уровню гемолиза, содержанию гемоглобина дозе, количеству осмотически неустойчивых разница между...
Background. In multiple myeloma (MM) treatment a single autologous hematopoietic stem cell transplantation (auto-HSCT) is preceded by conditioning regimens aimed at intensifying cytoreductive effect. the course of ongoing search for combined an attractive option proved to be thiotepa/melphalan combination. Aim. Data analysis pilot study efficacy including administration two alkylating agents (thiotepa and melphalan) with subsequent auto-HSCT. Materials & Methods. 9 patients received 10...
Relevance . Human neutrophil antigens (HNAs) are localized on glycoproteins which positioned the surface membrane of human neutrophils. Alloantibodies against HNA implicated in a number clinical conditions, including immune-mediated neutropenia and transfusion reactions. Genotyping for systems is important diagnosis disorders involving alloimmunization to HNA. Aim To assess risk donors patients with hematological diseases St. Petersburg based study allele genotype frequencies. Materials...
The main histocompatibility complex — HLA system (Human Leukocyte Antigens) is among the most important genetic factors determining response of humans to infectious agents. key role that molecules play in immune present pathogen-derived peptides. Enormous molecular variability alleles human populations have attracted close attention and became basis for numerous studies aimed at evaluating genotypes individual features COVID-19, new infection caused by SARS-CoV-2 β-coronavirus. Many focused...
The review presents current data on the role of viral hepatitis B in on-cohematological patients. Possible ways infection, prophylaxis infection and activation this category patients are considered. Specific features course various clinical situations described: against background other infections conduct specific anti-leukemia therapy. need to identify occult (occult) donors with hemoblastosis is emphasized methods for its detection
Aim. To analyze the effect on prognosis of mutations that are typical acute myeloid leukemia (AML) patients. Materials & Methods. The study included 620 AML patients surveyed at Hematology Clinics Saint Petersburg (Russia) and Charite Clinic (Berlin, Germany). G-banding chromosomes was employed for cytogenetic testing. Aberration screening in DNMT3A, IDH1/2 genes based real-time polymerase chain reaction (PCR) with subsequent analysis melting sequencing profiles. Mutations FLT3, NPM1...
Secondary myeloid neoplasia may be a complication of intensive cytostatic therapy. The most common types secondary neoplasias are acute leukemia and myelodysplastic syndrome. development atypical chronic (aCML) is an extremely rare phenomenon. paper describes transformation syndrome to aCML 6 months after its diagnosis. was accompanied by additional chromosomal aberration as monosomy chromosome 17. No mutations in the JAK2, MPL, CalR genes were detected. It concluded that clinical course...
Background. Autologous hematopoietic stem cell transplantation (auto-HSCT) is an indispensable treatment stage in patients with newly diagnosed multiple myeloma (MM) who are, based on age and health status, eligible for high-dose chemotherapy subsequent auto-HSCT. However, the issue of double (tandem) auto-HSCT feasibility remains unresolved. Aim. To compare overall survival (OS) progression-free (PFS) MM after single auto-HSCTs clinical practice. Materials & Methods. Retrospective...
Aim. To assess the possibility of using blood group genotyping in recipients who received transfusions for 3 months. Methods. The study included samples from 95 patients or more erythrocyte within had following diagnoses: multiple myeloma (n=7), beta thalassemia (n=4), non-Hodgkin's lymphomas (n=11), chronic myeloid leukemia (n=16), primary myelofibrosis (n=9), myelodysplastic syndrome (n=22), acute (n=21), aplastic anemia (n=5). Red cells phenotyping was performed Diaclon Rh Subgroups+K Gel...