A5038979701- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Plant Pathogens and Fungal Diseases
- Nail Diseases and Treatments
- Microbial Community Ecology and Physiology
- Yeasts and Rust Fungi Studies
- Fungal Infections and Studies
- Microbial infections and disease research
- Escherichia coli research studies
- Gut microbiota and health
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Resistance in Bacteria
- Immune responses and vaccinations
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Probiotics and Fermented Foods
- Neural and Behavioral Psychology Studies
- Polar Research and Ecology
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Colorectal Cancer Screening and Detection
- Image Processing and 3D Reconstruction
- Vibrio bacteria research studies
- Reproductive tract infections research
- EEG and Brain-Computer Interfaces
North-Western State Medical University named after I.I. Mechnikov
2016-2025
Czech Academy of Sciences, Institute of Experimental Medicine
2022-2025
Institute of Experimental Medicine
2022-2024
National Research University Higher School of Economics
2022-2024
St. Petersburg Research Institute of Radiation Hygiene
2017-2022
Candida auris is an emergent yeast pathogen, easily transmissible between patients and with high percent of multidrug resistant strains. Here we present a draft genome sequence the first known Russian strain C. auris, isolated from case candidemia. The clustered within South Asian clade seemingly represented independent event dissemination original species range. Observed fluconazole resistance was probably due to F105L K143R mutations in ERG11.
Introduction. Pathogenic strains of Escherichia coli are an important object surveillance within the One Health concept in wild, agriculture and human society. Migratory bird colonies high latitude avian may be points active intraspecies interspecies contact between different animal species, accompanied by spread pathogens. At same time, phylogeography E. relation to presence natural foci colibacillosis polar regions remains virtually unstudied. The aim this study was assess pathogenic...
Relevance . Obtaining clean lysis spots, with tolerable presence of individual colonies secondary growth, in spot tests is a criterion for assessing the effectiveness therapeutic bacteriophages. At same time, number mechanisms are known by which phage bacteria on lawns occurs without being accompanied virus replication. Aim To assess ratio test results and based detection negative bacteriophage colonies. Conclusion Data 43 bacteriophages extracted from 21 articles were analyzed. Within...
Background . Superinfection caused by Klebsiella pneumoniae occupies a leading position in the structure of bacterial complications COVID-19 patients. The intensive circulation specialised hospitals has contributed to consolidation most clinically and epidemiologically important strains this pathogen, particular, representatives hypervirulent carbapenem-resistant clonal lines, which have not lost their relevance even post-pandemic period. use bacteriophages as therapeutic anti-epidemic...
The fungi Trichophyton mentagrophytes and T. interdigitale are closely related species, causing superficial infections in humans other mammals. status of these taxa is a field long-lasting debates. To clarify their phylogenetic relationships within the genus sharpen species boundaries, we performed sequencing four genomes also evaluated three previously published multilocus data sets. We computational delimitation analysis on all available GenBank internal transcribed spacer region (ITS)...
The rapid emergence of antibiotic resistance is major concern globally. Among the most worrying pathogenic bacteria are vancomycin-resistant enterococci. Phage therapy a highly promising method for controlling enterococcal infections. In this study, we described two virulent tailed bacteriophages possessing lytic activity against
ABSTRACT Enterococcus faecium 58m is a putative ancient nonpathogenic strain isolated from the intestinal content of an adult woolly mammoth ( Mammuthus primigenius ). Here, we report its draft genome sequence, consisting 60 contigs. In silico genomic analysis was performed to determine genetic features and pathogenic potential this microorganism.
Recognition memory is an essential form of retrieval, allowing us to determine whether a thing or episode we experience in the present has been experienced past. typically involves decisions on stimuli look "old" "new". These can be difficult, especially when new are similar old ones (e.g., as police lineup identification). Although role similarity between (targets) and (foils) recognition obvious, it often hard predict how confusable particular targets foils would much their confusability...
Introduction: Arctic ecosystems are the most important object of microbiological surveillance that helps monitor a rapidly changing natural environment affected by climate change and industrial development northern territories. Objective: To assess epidemic potential opportunistic bacteria associated with animals from islands Barents Kara Seas. Materials methods: We have studied four strains gram-negative (Serratia fonticola, Aeromonas salmonicida, Yersinia kristensenii, rochesterensis)...
The features of gut microbiota in metabolic syndrome (MS) and ways to correct it using autoprobiotics, based on indigenous bacteria obtained from fecal samples the host, remain unexplored. aim study was investigate effectiveness an consortium (IC) treatment patients with MS. carried out 36 MS, manifested abdominal obesity, eating disorders, dyslipidemia, hypertension. control group formed by 20 healthy volunteers. Samples IC content were examined qPCR metagenome (16S rRNA) analysis before...
The aggressive infectious nature of SARS-CoV-2, its rapid spread, and the emergence mutations necessitate investigation factors contributing to differences in SARS-CoV-2 susceptibility severity. role genetic variations human HLA continues be studied various populations terms both effect on morbidity clinical manifestation illness. study included 484 COVID-19 convalescents (northwest Russia residents St. Petersburg). Cases which responsible strain was determined were divided two subgroups:...
The Trichophyton rubrum species group consists of prevalent causative agents human skin, nail and hair infections, including T sensu stricto violaceum, as well other less well-established or debatable taxa like soudanense, kuryangei megninii. Our previous study provided limited evidence in favour the existence two genetic lineages Russian population.We aimed to structure population identify factors shaping this structure.We analysed polymorphism 12 simple sequence repeat (SSR microsatellite)...
Trichophyton rubrum is an important causative agent of superficial mycoses worldwide. To uncover a genetic composition local population this fungus, we sequenced A7C99_6411 and A7C99_6714 loci, coding for hypothetical proteins revealed two complex genotypes, differing by single missense mutation in each locus. One the A7C99_6411/6714 genotypes was not found tinea pedis cases demonstrated mostly longer TRS-1 elements when compared to another genotype. Thus, present description nucleotide...
One of the central topics in bacteriophage research is host specificity. It depends on success completing viral life cycle stages, including adsorption, penetration genetic material virus into cell and its replication, assembly phage particles lysis. Laboratory assessments spectrum lytic activity phages are inextricably linked to significant methodological biases, often used spot test method can be associated with a large percentage false-positive results. Along variety types specificity,...
Introduction: The incidence of salmonellosis in St. Petersburg remains at one the highest levels Russian Federation. Objective: To establish features epidemic process Salmonella infection among residents Petersburg, including those outpatients. Materials and methods: study was conducted years 2020 to 2023 consisted a retrospective epidemiological analysis data retrieved from register infectious parasitic diseases kept by Center for Hygiene Epidemiology city Leningrad Region 2017–2021 medical...
Relevance. Escherichia marmotae is a recently described species of that considered potential new zoonotic pathogen. The geographical distribution this microorganism in wild animals and its genomic diversity are currently insufficiently studied. Aims. purpose the study was to determine pathogenic 16guk strain isolated from zoogenic material on Hooker Island (Arkhangelsk Region, Franz Josef Land Archipelago) phylogenetic relationships with previously strains different origin. Materials methods...
Relevance. Colorectal cancer (CRC) is the second leading cause of mortality worldwide. Non-invasive diagnostic methods based on determination hidden blood in stool (fecal immunochemical test, guaiac test), which have been proven to be effective clinical studies, are used for CRC screening. However, a significant disadvantage available non-invasive low sensitivity detecting oncological process at early stages. A number recent studies discuss relationship between disease and various...
The main histocompatibility complex — HLA system (Human Leukocyte Antigens) is among the most important genetic factors determining response of humans to infectious agents. key role that molecules play in immune present pathogen-derived peptides. Enormous molecular variability alleles human populations have attracted close attention and became basis for numerous studies aimed at evaluating genotypes individual features COVID-19, new infection caused by SARS-CoV-2 β-coronavirus. Many focused...
Serratia marcescens is a frequent cause of health care-associated infections and has led to multiple outbreaks. Here, we report the draft genome multidrug-resistant S. strain 189 which was isolated in 2012 as predominant clone neonatal hospital Kemerovo.
Severe course of COVID-19 in inpatients can be caused by a number reasons, including viral and bacterial superinfections. Empirical use antibiotics, as well poor infectious control stimulate the emergence spread multidrug-resistant bacteria. Klebsiella pneumoniae is most common carbapenemase-producing pathogen causing nosocomial infections. These strains became significantly widespread during pandemic. Objective. To analyze phenotypic genetic characteristics K. dominant severe patients...