Introduction. Pathogenic strains of Escherichia coli are an important object surveillance within the One Health concept in wild, agriculture and human society. Migratory bird colonies high latitude avian may be points active intraspecies interspecies contact between different animal species, accompanied by spread pathogens. At same time, phylogeography E. relation to presence natural foci colibacillosis polar regions remains virtually unstudied. The aim this study was assess pathogenic...

Relevance . Obtaining clean lysis spots, with tolerable presence of individual colonies secondary growth, in spot tests is a criterion for assessing the effectiveness therapeutic bacteriophages. At same time, number mechanisms are known by which phage bacteria on lawns occurs without being accompanied virus replication. Aim To assess ratio test results and based detection negative bacteriophage colonies. Conclusion Data 43 bacteriophages extracted from 21 articles were analyzed. Within...

The issue of combating antimicrobial resistance has been relevant for several decades, since the arsenal effective antibiotics used in infectious diseases is significantly reduced, and development new antibacterial drugs difficult expensive. At same time, possibility widespread use bacteriophages hospital settings being discussed. Goal. Evaluation sensitivity to strains K.pneumoniae isolated from patients departments surgery intensive care Structure Clinical Infectious Disease Hospital named...

The intensive development of medical technologies is accompanied by equally rapid changes in the epidemic process healthcare-associated infections (HAIs). According to experts, order increase sensitivity surveillance system, official registration should be supplemented multicenter targeted studies. Aim . To determine prevalence and incidence HAIs care units (ICUs) Russian Federation, dominant pathogens their antibiotic resistance. Materials Methods A one-day epidemiological interregional...

Background . Superinfection caused by Klebsiella pneumoniae occupies a leading position in the structure of bacterial complications COVID-19 patients. The intensive circulation specialised hospitals has contributed to consolidation most clinically and epidemiologically important strains this pathogen, particular, representatives hypervirulent carbapenem-resistant clonal lines, which have not lost their relevance even post-pandemic period. use bacteriophages as therapeutic anti-epidemic...

Colorectal cancer (CRC) is one of the most common malignant tumours, which development significantly depends on role gut microbiota. Here we discuss possibilities using individual microorganisms as biomarkers for CRC screening. During tumorigenesis, a complex interaction established between microbiome, tumor microenvironment and immune system. The composition fecal microbiome in patients with characterized by reduced numbers protective ( Clostridiales, Roseburia, Feacalibacterium ) increased...

Introduction: Arctic ecosystems are the most important object of microbiological surveillance that helps monitor a rapidly changing natural environment affected by climate change and industrial development northern territories. Objective: To assess epidemic potential opportunistic bacteria associated with animals from islands Barents Kara Seas. Materials methods: We have studied four strains gram-negative (Serratia fonticola, Aeromonas salmonicida, Yersinia kristensenii, rochesterensis)...

Influenza A virus is characterized by a segmented single-stranded RNA genome. Such organization of the genome determines possibility reassortment, which can lead to emergence new variants. The main natural reservoir most influenza subtypes are wild waterfowl. Seasonal migrations gather waterfowl from all major migration routes nesting areas near northern and southern polar circles. This makes intercontinental spread viruses possible. Objective ‒ conduct molecular genetic monitoring study...

The global spread of IBD is likely due to the westernization diet and environment, which leads changes in gut microbiome increases risk disease people with a genetic predisposition. In light increasing incidence worldwide, it important evaluate factors order develop prognostic models for various variants course UC CD methods combat these diseases. This review article examines key aspects related negative beneficial effects on development IBD. data shows that smoking (OR = 1.76; 95% CI:...

Antibiotic resistance threatens the effective prevention and treatment of healthcare associated infections which are most frequent adverse event in health-care settings worldwide. There is an urgent need to investigate alterative preventive options while there still a few antibiotics left. Bacteriophage (phage) therapy has been championed as promising alternative antibiotics. The aim this study was evaluate efficacy therapeutic bacteriophages control Staphylococcus aureus Klebsiella...

The article discusses the methodological foundations of epidemiological diagnostics - basis for risk-oriented approach to prevention healthcare-associated infections (HAI). It outlines goals, objectives, basic terms and sequence steps in organization conduct diagnostics. importance surveillance HAI is underlined. describes main principles descriptive analytical studies structure HAI.

Microbiological monitoring, being an integral component of epidemiological surveillance healthcare associated infection (HAI), is one the most important components in hospital patient safety. The purpose monitoring etiological interpretation pathogens, identification microbial strains and development strategies as well tactics for combating them. In modern conditions humanity a whole, problem steady increase number HAI caused by antimicrobial drug-insensitive pathogens decreased drug...

Relevance. Infections caused by methicillin-resistant strains of Staphylococcus aureus are an urgent problem hospital epidemiology, and control measures involve the development new antimicrobials. Probiotics based on bacterial isolated fro natural habitats considered promising means combating MRSA. Aims. To test possibility using Bacillus safensis 440-1 strain from Antarctic soil. as antibacterial agent for treatment experimental staphylococcal infection. Purpose study – check strain, soil,...

One of the central topics in bacteriophage research is host specificity. It depends on success completing viral life cycle stages, including adsorption, penetration genetic material virus into cell and its replication, assembly phage particles lysis. Laboratory assessments spectrum lytic activity phages are inextricably linked to significant methodological biases, often used spot test method can be associated with a large percentage false-positive results. Along variety types specificity,...

Endometriosis is one of the most common and understudied diseases in women all over world. The more than a century-old history endometriosis research does not currently provide unambiguous answers about causes, risk factors, etiology methods its treatment. Chronic pelvic pain as main symptoms cause only physical suffering, but also negative change mental status women, deterioration their quality life. Body-oriented treating disease often turn out to be ineffective. relationship between...

The article discusses the use of bacteriophages as a promising research area creating effective and environmentally friendly tools methods for combating antimicrobial resistance natural pollution. Breakthrough technologies developing customized polyvalent (complex) genetically engineered phages well their structural elements will improve quality patient care, increase epidemiological well-being population, reduce risks infectious non-infectious morbidity toxic load on environment. above...

Relevance. Escherichia marmotae is a recently described species of that considered potential new zoonotic pathogen. The geographical distribution this microorganism in wild animals and its genomic diversity are currently insufficiently studied. Aims. purpose the study was to determine pathogenic 16guk strain isolated from zoogenic material on Hooker Island (Arkhangelsk Region, Franz Josef Land Archipelago) phylogenetic relationships with previously strains different origin. Materials methods...

Relevance. Colorectal cancer (CRC) is the third most common in world. In Russian Federation, high rates of neglect late diagnosis colon have been established. The study complex influence social, clinical, anamnestic and dietary risk factors development colorectal valuable identifying groups for effective secondary prevention. Aims. Assessment importance medical clinical anamnestic, alimentary-dependent as cancer. Materials & Methods. To analyse regional characteristics CRC incidence,...

Relevance. Colorectal cancer (CRC) is the second leading cause of mortality worldwide. Non-invasive diagnostic methods based on determination hidden blood in stool (fecal immunochemical test, guaiac test), which have been proven to be effective clinical studies, are used for CRC screening. However, a significant disadvantage available non-invasive low sensitivity detecting oncological process at early stages. A number recent studies discuss relationship between disease and various...

Introduction. The epidemic process of medical care-related infections complies to the general laws for development process, although it has specific features. probability surgical site infection becomes precipitated by risk factors, which contribute emergence based on traits pathology, patient populations and specifics hospital facility. aim study was evaluate HIV-related effect developing in patients with chronic spondylitis. Materials methods. A retrospective cohort epidemiological...

Introduction. Cystitis is one of the most common bacterial infections in women. Postcoital cystitis (PC) a special form recurrent cystitis. Non- antibacterial methods prophylaxis are often ineffective. The use post-coital antibiotic has good result, but this approach contradicts current concept rational use. Therefore, bacteriophages have high interest among medical community as an alternative therapy. Aim. To evaluate efficacy using for, for postcoital patients with PC. Material and...

Here, we provide an analysis on 1996–2016 St. Petersburg tick-borne encephalitis (TBE) epidemiological and ecological data. In particular, two main TBE transmission vectors were observed in Petersburg: Ixodes persulcatus ricinus. tick contamination was 0.61% as shown by ELISA polymerase chain reaction It is found that number of subjects seeking for medical aid due to bites rises, whereas incidence declines. a mean 1996–2002 vs. 2010–2016 tick-bite rate increased from 141.9 up 288.9,...

Lesions of the digestive system in diabetes mellitus (DM) are secondary nature and arise due to autonomic neuropathy. As a result hyperglycemia, lesions esophagus, stomach, small large intestine develop. The most common disorder is gastroparesis. diagnosis gastroparesis currently insufficient. It connected with low awareness and, as consequence, rare visit patients specialists, also similarity clinical symptoms other functional disorders gastrointestinal tract (GIT). main risk factors for...

Objective. To study bactericidal effect of continuous spectrum ultraviolet radiation on hospital flora and evaluate microbiological efficiency using portable pulsed unit for disinfection air open surfaces in a medical organization. During the study, it was found that selected research methods probably did not allow to achieve higher values shorter processing times. Materials methods. The strains microorganisms were used taken from various loci patients department anesthesiology intensive care...