A5042307461- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Esophageal and GI Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Frailty in Older Adults
- Enhanced Recovery After Surgery
- Multiple and Secondary Primary Cancers
- Genetic factors in colorectal cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Ovarian cancer diagnosis and treatment
- Biliary and Gastrointestinal Fistulas
- Hepatitis B Virus Studies
- Economic and Financial Impacts of Cancer
- Blood transfusion and management
National Cancer Center
2016-2025
Kangwon National University
2019
Chonnam National University Hwasun Hospital
2016
<h3>Importance</h3> Ovarian cancer has the highest mortality rate among gynecologic malignant tumors. Data are lacking on survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) in women with ovarian who underwent primary or interval cytoreductive surgery. <h3>Objective</h3> To assess clinical HIPEC after maximal surgery stage III IV advanced cancer. <h3>Design, Setting, and Participants</h3> In this single-blind randomized trial performed at 2 institutions South Korea from...
Given the increasing trend of cholecystectomy, it is imperative to reassess surgical and surveillance strategies in consideration potential long-term risks for digestive tract cancers. The objective this study was assess risk gastrointestinal (GI) hepato-biliary-pancreatic (HBP) cancer incidence after cholecystectomy. data cohort obtained from National Health Insurance Service database Korea. 715,872 patients who underwent cholecystectomy between 2004 2020 were compared 1,431,728 individuals...
This study investigated epidemiologic features of patients with pancreatic cancer in Korea, according to the histologic subtypes. The Korea Central Cancer Registry data on from 1999 2019 were reviewed. 101,446 (C25 based International Classification Diseases, 10th revision) allocated following morphological codes: A, endocrine; B, carcinoma excluding cystic and mucinous; C, or D, acinar cell; E, sarcoma soft tissue tumor. distribution each subtype group was as follows: n = 3,101 (3.1%);...
Several pancreatic adenocarcinoma (PA) biomarkers beyond the traditional carbohydrate antigen (CA)19-9 have been identified but are lacking large-scale prospective validation. This cohort study evaluated prognostic impact of potential PA biomarkers. We enrolled 238 288 patients with histologically proven PA. assessed candidate biomarkers, including CA19-9, germline BRCA1/2, and ATM mutations, as well mutant KRAS circulating tumor DNA (ctDNA) in blood samples. Additionally, we expression...
Abstract Biliary tract cancer (BTC) has been inconsistently identified according to its location in epidemiological and clinical studies. This study retrospectively reviewed the treatment pattern prognosis of BTC tumor using Korea Central Cancer Registry data 97,676 patients with from 2006 2017. The proportion localized regional Surveillance, Epidemiology, End Results (SEER) stage was highest ampulla Vater (AoV, 78.2%) cancer, followed by extrahepatic bile duct (BD, 68.3%), gallbladder (GB,...
We designed a retrospective study to compare prognostic outcomes based on whether or not surgical resection was performed in elderly patients aged(≥75 years) with resectable pancreatic cancer.We retrospectively analyzed 49 cancer (surgery group, for 38 cases; no surgery 11 cases) diagnosed from January 2003 December 2014 at the National Cancer Center, Korea.There significant difference demographics between two groups. The group showed significantly better overall survival after diagnosis...
Abstract Background and Aim In most patients with perihilar cholangiocarcinoma (PHCC), major hepatectomy extrahepatic bile duct resection are needed for surgical radicality, a high risk of hepatic insufficiency exists. This study aims to develop prediction model post‐hepatectomy liver failure (PHLF) in PHCC. Methods A total 143 who underwent PHCC between October 2001 December 2013 were included. Clinically relevant PHLF was defined as corresponding grade B or C the International Study Group...
We designed the study to clarify prognostic significance of perioperative (preoperative, intraoperative, and postoperative) red blood cell (RBC) transfusion following pancreaticoduodenectomy (PD) for periampullary cancers. This retrospectively analyzed 244 cancer patients (pancreatic cancer, 124 patients; bile duct 63 ampullary 57 patients) treated by PD from June 2001 2010 at National Cancer Center, Korea (NCC2017-0106). A total 112 (46%) had received 5%; 17%; postoperative, 37%). The...
Abstract We aimed to identify the factors for very early recurrence (within 6 months) of ampullary cancer following curative resection and compare immunohistochemical expression rate various antibodies between 2 main histologic subtypes adenocarcinoma. In this retrospective study, postoperative outcomes clinicopathologic that occurred in 14 93 patients who underwent pancreaticoduodenectomy (PD) adenocarcinoma January 2002 August 2014 were analyzed. Thereafter, we identified associated with...
Hospital-based clinical studies have limitations in holistic assessment of cancer treatment and prognosis, as they omit out-of-hospital patients including elderly individuals. This study aimed to investigate trends initial corresponding prognosis with exocrine pancreatic (EPC) Korea.
Despite hepatolithiasis being a risk factor for biliary neoplasm including cholangiocarcinoma, the incidence of underlying is unknown in patients with preoperative benign hepatolithiasis. The aim this study was to evaluate who underwent major hepatectomy hepatolithiasis.Between March 2005 and December 2015, 73 were enrolled study. pathological differentiation concomitant retrospectively determined by review medical records. Postoperative complications after evaluated.Concomitant...
We describe 2 cases of patients with loss hepatic arterial flow during surgery for pancreatic head cancer due to celiac stenosis caused by median arcuate ligament compression. The first case underwent pylorus-resecting pancreatoduodenectomy cancer. After resection the gastroduodenal artery, in common artery disappeared, and axis was identified. Interventional stent insertion attempted, however, it failed acute angle orifice (os). This problem resolved reconstruction. second...
This study aimed to analyze the current trends and predict epidemiologic features of hepatobiliary pancreatic (HBP) cancers according Korea Central Cancer Registry provide insights into health policy.Incidence data from 1999 2017 mortality 2002 2018 were obtained National Incidence Database Statistics Korea, respectively. The future incidence rate 2040 2019 each HBP cancer predicted using an age-period-cohort model. All analyses, including mortality, stratified by sex.From 2017,...
Abstract Background We hypothesized that a learning curve exists for pancreatoduodenectomy (PD) and the factors show degree of improvement over time differ among surgeons. Methods analysed outcomes PD in 300 patients operated by two surgeons between 2001 2014; these comprised first 150 each surgeon. Patients surgeon were classified into three groups according to chronological sequence operation (50 per group). Results For A, median (496 versus 454 418 min, P < 0.001) mean amount red blood...
Misclassification of Klatskin tumor as intrahepatic rather than extrahepatic bile duct cancer (eBDC) may overestimate the incidence BDC (iBDC). This study aimed to investigate impact misclassified on iBDC and eBDC incidences in Korea, where is highly endemic.The data incidence, topography morphology code from 1999 2017 were obtained Korea Central Cancer Registry, which covers entire 51.6 million Korean population. For misclassification analysis, all tumors reclassified eBDC.Klatskin...
In malnourished patients, postoperative morbidity, hospitalization period, and medical expenses are reportedly to be high. We evaluated the clinical impact of a preoperative nutritional support program (PNSP) among cancer patients.
Portal vein embolization (PVE) is increasingly performed worldwide to reduce the possibility of liver failure after extended hepatectomy, by inducing future remnant (FLR) hypertrophy and atrophy planned for resection. The procedure known be very safe have few procedure-related complications. In this study, we described 2 elderly patients with Bismuth–Corlette type IV Klatskin tumor who underwent right trisectional PVE involving portal vein, left medial sectional branch, caudate vein. Within...
The objective of this study is to investigate the surgical, clinical and pathological outcomes left hemi-hepatectomy during cytoreductive surgery (CRS) in patients with primary ovarian cancer. electronic medical charts cancer who received CRS including from 2000 2023 were reviewed retrospectively analyzed. A total 17 underwent for resection a deep peritoneal implant round ligament liver CRS. Among these patients, hepatic parenchymal invasion was confirmed 10 (58.8%). Tumor distribution...
Perioperative transfusion is reported to be an independent risk factor not only for postoperative complications but also early recurrence of periampullary carcinoma after pancreaticoduodenectomy (PD). The purpose this study was evaluate the safety and efficacy ferric carboxymaltose (FCM) in reducing need perioperative iron deficiency anemia patients scheduled PD.Twenty-two male (hemoglobin [Hb] 7 <13 g/dL) 18 female (Hb <12 were enrolled group administered FCM 1-3 weeks before PD. rate...
Backgrounds/Aims: Although cancer survivors are at higher risk of developing second primary malignancies, surveillance strategies for them have not yet been established.This study aimed to identify first cancers that had high risks exocrine pancreatic (EPC).Methods: Data on individuals diagnosed with between 1993 and 2017 were obtained from the Korea Central Cancer Registry.The standardized incidence ratios (SIRs) EPCs analyzed according tumor sites follow-up periods.Results: Among 3,205,840...
Patients undergoing pancreatoduodenectomy are a high-risk group that requires psychosocial support. This study retrospectively reviewed the prevalence of psychological symptoms in patients for periampullary neoplasm and referral rate after implementing full screening triage algorithm administering distress management protocol based on integrated supportive care system established 2010.From September 2010 to December 2018, insomnia, anxiety, depression were screened first day admission (T1)...