A5084493213- Monoclonal and Polyclonal Antibodies Research
- Analytical Methods in Pharmaceuticals
- Drug Solubulity and Delivery Systems
- Analytical Chemistry and Chromatography
- Viral Infections and Vectors
- Drug Transport and Resistance Mechanisms
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Mast cells and histamine
- Cancer therapeutics and mechanisms
- Eicosanoids and Hypertension Pharmacology
- Computational Drug Discovery Methods
- Helicobacter pylori-related gastroenterology studies
- Glycosylation and Glycoproteins Research
- Cardiomyopathy and Myosin Studies
- Estrogen and related hormone effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Viral Infections and Outbreaks Research
- Ion channel regulation and function
- HER2/EGFR in Cancer Research
- Synthesis and Biological Evaluation
- Transgenic Plants and Applications
- Hepatitis B Virus Studies
- DNA and Nucleic Acid Chemistry
- Protein purification and stability
Sanofi (France)
2011-2022
Novartis (Switzerland)
2016
University of Manchester
2016
Université Claude Bernard Lyon 1
2013
More than 75% of breast cancers are estrogen receptor alpha (ERα) positive (ER+), and resistance to current hormone therapies occurs in one-third ER+ patients. Tumor is still ERα-dependent, but mutations usually confer constitutive activation the receptor, rendering ERα modulator drugs such as tamoxifen aromatase inhibitors ineffective. Fulvestrant a potent selective degrader (SERD), which degrades drug-resistant tumors has been approved for treatment hormone-receptor-positive metastatic...
Filoviridae currently includes five official and one proposed genera. Genus Ebolavirus established ebolavirus species for Bombali virus (BOMV), Bundibugyo (BDBV), Ebola (EBOV), Reston (RESTV), Sudan (SUDV) Taï Forest (TAFV), genus Marburgvirus a single Marburg (MARV) Ravn (RAVV). (EBOV) has emerged as significant public health concern since the 2013–2016 Virus Disease outbreak in Western Africa. Currently, there are no therapeutics approved need Ebola-specific remains gap. In search...
Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per molecule. The combination different binding affinities classes, such as soluble membrane-bound antigens, within multispecific confers unique pharmacokinetic (PK) properties. Numerous factors affect antibody's PK, with affinity to neonatal Fc receptor (FcRn) a...
A new strategy of peptide half-life extension has been evaluated. We investigated libraries a small and very stable protein scaffold called Nanofitin, capable high affinity for targets. have identified Nanofitins targeting Human mouse Serum Albumin, which could significantly improve the pharmacokinetics an active associated peptide, mobilizing patient's own albumin without external source. To demonstrate impact this approach on extension, genetic fusion Exenatide with Albumin Binding...
During 2007–2008, serious adverse events were reported following iv administration of certain batches commercially available heparin in humans. Anaphylactoid reactions with acute hypotension the hallmark these cases. Subsequently, it was shown that a contaminant, oversulfated chondroitin sulfate (OSCS), responsible for events. The present study undertaken to further elucidate risks related OSCS-contaminated preparations. Using an anesthetized rat hemodynamic model, marked diastolic blood...
Dilated cardiomyopathy (DCM) is a disease of the myocardium defined by left ventricular enlargement and systolic dysfunction leading to heart failure.Danicamtiv, new targeted myosin activator designed for treatment DCM, was characterised in vitro vivo preclinical studies.Danicamtiv human hepatic clearance predicted be 0.5 mL/min/kg from metabolic stability studies hepatocytes. For human, plasma protein binding moderate with fraction unbound 0.16, whole blood-to-plasma partitioning ratio 0.8,...