A5036200664- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- interferon and immune responses
- Prostate Cancer Treatment and Research
- Plant Molecular Biology Research
- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Gut microbiota and health
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cell death mechanisms and regulation
- Plant Gene Expression Analysis
- Brain Metastases and Treatment
- RNA Research and Splicing
- Bone Metabolism and Diseases
University of South China
2022-2025
Southern Medical University
2025
Nanfang Hospital
2025
Central South University
2001-2024
Hunan Provincial Maternal and Child Health Hospital
2023-2024
Scripps Research Institute
2010-2024
Xiangya Hospital Central South University
2001-2024
University of Benin
2022
Zunyi Medical University
2022
ZheJiang Academy of Agricultural Sciences
2016
Cytokine signaling is thought to require assembly of multicomponent complexes at cytoplasmic segments membrane-embedded receptors, in which receptor-proximal protein kinases are activated. Indeed, CD40, a tumor necrosis factor receptor (TNFR) family member, forms complex containing adaptor molecules TRAF2 and TRAF3, ubiquitin-conjugating enzyme Ubc13, cellular inhibitor apoptosis proteins 1 2 (c-IAP1/2), IkappaB kinase regulatory subunit IKKgamma (also called NEMO), mitogen-activated (MAPK)...
NF-kappaB is constitutively active in many solid tumors, including breast cancer. However, the role of carcinogenesis unknown. Ikkalpha(AA/AA) "knockin" mice which activation IkappaB kinase alpha (IKKalpha) prevented by replacement loop serines with alanines exhibit delayed mammary gland growth during pregnancy, because IKKalpha activity required for cyclin D1 induction and proliferation lobuloalveolar epithelial cells. Given cancer, we examined involvement induced oncogenes or a chemical...
The Panax ginseng C.A. Meyer belonging to the Araliaceae has long been used as an herbal medicine. Although public databases are presently available for this family, no methyl jasmonate (MeJA) elicited transcriptomic information was previously reported on species, with exception of a few expressed sequence tags (ESTs) using traditional Sanger method. Here, approximately 53 million clean reads adventitious root transcriptome were separately filtered via Illumina HiSeq™2000 from two samples...
The discovery/optimization of bis-aryl ureas as Limk inhibitors to obtain high potency and selectivity appropriate pharmacokinetic properties through systematic SAR studies is reported. Docking supported the observed SAR. Optimized had biochemical (IC50 < 25 nM), excellent against ROCK JNK kinases (>400-fold), potent inhibition cofilin phosphorylation in A7r5, PC-3, CEM-SS T cells 1 μM), good vitro vivo properties. In profiling a panel 61 kinases, compound 18b at μM inhibited only Limk1...
To investigate the incidence rate, risk factors, and clinical implications of postoperative pulmonary complications (PPCs) in patients undergoing colorectal cancer surgery (CRC). The study extracted data from National Inpatient Sample (NIS) between 2010 2019. Patients' were analyzed to identify predictors PPCs, association possible factors PPCs also assessed. A total 169,067 CRC included 15,494 (9.16%) diagnosed with study. Our found that age, gender, number comorbidities, type location...
Increasing evidence suggests that the noncanonical IKKs play critical roles in tumor genesis and development, leading to notion may be good targets for cancer therapy. Here, we demonstrate although TBK1 is not overexpressed or constitutively activated some cells, targeting IKKi induces activation of TBK1. Therefore, simultaneously both kinases necessary efficiently suppress cell proliferation. We show three TBK1/IKKi dual inhibitors, which are based on a structurally rigid...
WRKY proteins belong to a transcription factor (TF) family and play dynamic roles in many plant processes, including responses abiotic biotic stresses, as well secondary metabolism. However, no gene Panax ginseng C.A. Meyer has been reported date. In this study, number of unigenes from methyl jasmonate (MeJA)-treated adventitious root transcriptome species were identified using next-generation sequencing technology. A total 48 promising encoding obtained by eliminating wrong incomplete open...
<title>Abstract</title> Pre-mRNA processing factor 19 (PRPF19) is a multifaceted protein and participates in DNA damage response pre-mRNA processing. The role of PRPF19 cancer unclear. Here, we report that the expression human tongue associated with unfavorable prognosis. Overexpression promotes while knockdown inhibits cell migration, proliferation, tumor growth. increases resistance cells to radiation cisplatin treatment. Furthermore, regulates solute carrier family 40 member 1 (SLC40A1)...
Androgen deprivation therapy (ADT) is a systemic for advanced prostate cancer (PCa); although most patients initially respond to ADT, almost all cancers eventually develop castration-resistant PCa (CRPC). Currently, research focuses on tumors, and the role of tumors in remission completely ignored. Here, we report that odorant-binding protein (OBP2A) released from during ADT catches survival factors, such as CXCL15/IL8, promote cell androgen-independent growth enhance infiltration...