A5006557932- Immune Cell Function and Interaction
- Biochemical and Molecular Research
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- interferon and immune responses
- Historical and Environmental Studies
- Pancreatic function and diabetes
- Historical Economic and Social Studies
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Historical and socio-economic studies of Spain and related regions
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
Sidney Kimmel Comprehensive Cancer Center
2023
Johns Hopkins University
2020-2023
Bloomberg (United States)
2021-2023
Cancer Research Center
2023
Scripps Clinic
2022-2023
Scripps Green Hospital
2022-2023
Johns Hopkins Medicine
2020
Washington University in St. Louis
2011
Memory CD8+ T cells are characterized by their ability to persist long after the initial antigen encounter and capacity generate a rapid recall response. Recent studies have identified role for metabolic reprogramming mitochondrial function in promoting longevity of memory cells. However, detailed mechanisms involved response incompletely understood. Here, we identify continued activation trifunctional rate-limiting enzyme de novo pyrimidine synthesis pathway CAD (carbamoyl-phosphate...
Abstract In order to study mechanistic/mammalian target of rapamycin’s role in T cell differentiation, we generated mice which Rheb is selectively deleted cells (T-Rheb−/− C57BL/6J background). During these studies, noted that T-Rheb−/− were consistently heavier but had improved glucose tolerance and insulin sensitivity as well a marked increase beige fat. Microarray analysis Rheb−/− revealed expression kallikrein 1–related peptidase b22 (Klk1b22). Overexpression KLK1b22 vitro enhanced...
Abstract While the exquisite specificity of T-cell receptor (TCR) MHC + peptide interaction heralds recognition, it is ultimately cues from immune microenvironment that dictate outcome this recognition. Our lab has proposed mTOR plays a critical role in integrating signals and thus determining antigen Indeed, we have demonstrated mTORC1 mTORC2 signaling can selectively guide CD4+ effector regulatory differentiation function as well CD8+ memory function. Recent studies revealed performs part...
Abstract Memory CD8+ T cells are characterized by their ability to persist long after the initial antigen encounter and generate a rapid recall response. Recent studies have identified role for metabolic reprogramming mitochondrial function in promoting longevity of memory cells. However, detailed mechanisms involved response incompletely understood. Here we identify novel continued activation trifunctional rate-limiting enzyme de novo pyrimidine synthesis pathway CAD (carbamoyl-phosphate...