A5032843070- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Biofuel production and bioconversion
- CRISPR and Genetic Engineering
- Manufacturing Process and Optimization
- Anaerobic Digestion and Biogas Production
- RNA Research and Splicing
- Cyclone Separators and Fluid Dynamics
- Coal and Coke Industries Research
- Smart Grid and Power Systems
- Engineering Technology and Methodologies
- Power System Reliability and Maintenance
- Electric Power System Optimization
- Chemical Synthesis and Analysis
- Peptidase Inhibition and Analysis
- Microbial Metabolic Engineering and Bioproduction
- Click Chemistry and Applications
- Advanced Numerical Analysis Techniques
- Enzyme Production and Characterization
- Process Optimization and Integration
- RNA regulation and disease
- Enzyme Catalysis and Immobilization
- Neurogenetic and Muscular Disorders Research
- Agriculture, Plant Science, Crop Management
Wave Life Sciences (United States)
2022
China Southern Power Grid (China)
2019
Nanjing Forestry University
2017
University of Illinois Urbana-Champaign
2016
Jiangnan University
2015
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment neuromuscular disease such as Duchenne muscular dystrophy has been an advance field, current SSO chemistries have shown limited clinical benefit due to poor pharmacology. To overcome limitations existing technologies, we engineered chimeric stereopure with phosphorothioate (PS) and phosphoryl guanidine-containing (PN) backbones. We demonstrate that these markedly improved pharmacology efficacy...
DNA catalysts (deoxyribozymes) for a variety of reactions have been identified by in vitro selection. However, certain this identification has not achieved. One important example is DNA-catalyzed amide hydrolysis, which previous selection experiment instead led to phosphodiester hydrolysis. Subsequent efforts the strategy deliberately avoided hydrolysis ester and aromatic but aliphatic elusive. In present study, we show that including modified nucleotides bear protein-like functional groups...
We describe an unprecedented DNA-catalyzed DNA cleavage process in which a radical-based reaction pathway cleanly results excision of most atoms specific guanosine nucleoside. Two new deoxyribozymes (DNA enzymes) were identified by vitro selection from N40 or N100 random pools initially seeking amide bond hydrolysis, although they both cleave simple single-stranded oligonucleotides. Each deoxyribozyme generates superoxide (O2–• HOO•) and hydrogen peroxide (H2O2) leads to the same set...
The traditional generation unit maintenance optimization method focuses on the influence power supply capacity. However, with rapid development of new energy such as wind power, peak regulation capacity should be also considered. For this reason, three useful evaluation indexes are proposed including abundance(PSA), electricity abundance(ESA) and abundance(PRA) based maximum, minimum average operation schemes. Then, a monthly is put forward by taking requirements, PSA, ESA PRA into...
Reasonable process regulations and fixtures can ensure the high efficiency of parts processing economy enterprise. I started with data collection, then part analysis, design, specification finally fixture design. In obtained best route based on experience production site to achieve effect saving time increasing labor productivity. The design was program, type determined, compiled. Production, so card machining were is two sets tools for bearing box car mold drilling mold. processed large...