A5085480017- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- RNA Interference and Gene Delivery
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Microwave Imaging and Scattering Analysis
- Epilepsy research and treatment
- Viral Infections and Immunology Research
- Neuroscience and Neural Engineering
- Neurogenetic and Muscular Disorders Research
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
University of Lisbon
2019-2024
University of Oxford
2022
University of Coimbra
2016
Although recent regulatory approval of splice-switching oligonucleotides (SSOs) for the treatment neuromuscular disease such as Duchenne muscular dystrophy has been an advance field, current SSO chemistries have shown limited clinical benefit due to poor pharmacology. To overcome limitations existing technologies, we engineered chimeric stereopure with phosphorothioate (PS) and phosphoryl guanidine-containing (PN) backbones. We demonstrate that these markedly improved pharmacology efficacy...
There is a growing consensus that Alzheimer's disease (AD) involves failure of the homeostatic machinery, which underlies firing stability neural circuits. What are culprits leading to neuron instability? The amyloid precursor protein (APP) central AD pathogenesis, and we recently showed its intracellular domain (AICD) could modify synaptic signal integration. We now hypothesize AICD modifies activity, thus contributing disruption memory processes. Using cellular, electrophysiological,...
Abstract N‐methyl‐D‐aspartate receptors (NMDARs) are critical for the maturation and plasticity of glutamatergic synapses. In hippocampus, NMDARs mainly contain GluN2A and/or GluN2B regulatory subunits. The amyloid precursor protein (APP) has emerged as a putative regulator NMDARs, but impact this interaction to their function is largely unknown. By combining patch‐clamp electrophysiology molecular approaches, we unravel dual mechanism by which APP controls GluN2B‐NMDARs, depending on life...
N-methyl-D-aspartate receptors (NMDARs) are critical for the maturation and plasticity of glutamatergic synapses. In hippocampus, NMDARs mainly contain GluN2A and/or GluN2B regulatory subunits. The amyloid precursor protein (APP) has emerged as a putative regulator NMDARs, but impact this interaction to their function is largely unknown. By combining patch-clamp electrophysiology molecular approaches, we unravel dual mechanism by which APP controls GluN2B-NMDARs, depending on life stage. We...