- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Family Dynamics and Relationships
- Pregnancy and preeclampsia studies
- Endometriosis Research and Treatment
- Birth, Development, and Health
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
- Reproductive Physiology in Livestock
- Preterm Birth and Chorioamnionitis
- Cancer Risks and Factors
- Demographic Trends and Gender Preferences
- Homicide, Infanticide, and Child Abuse
- Pregnancy and Medication Impact
- Gynecological conditions and treatments
- Breastfeeding Practices and Influences
- Estrogen and related hormone effects
- Renal and related cancers
- Pregnancy-related medical research
- Autism Spectrum Disorder Research
Dartmouth Psychiatric Research Center
2022-2024
Dartmouth College
1997-2023
Dartmouth–Hitchcock Medical Center
2012-2023
Dartmouth Health
2022
Dartmouth Institute for Health Policy and Clinical Practice
2022
University of Missouri
2018-2020
University of Michigan
2007-2018
Massachusetts Department of Public Health
2014-2018
Yale University
2018
Michigan State University
2008-2015
BACKGROUNDObesity has risen among women in the USA, including those seeking infertility treatments. In 2007, height and weight were added to Society for Assisted Reproductive Technology Clinic Online Reporting System (SART CORS), permitting calculation of BMI (weight/height2) first time using this national dataset.
PROBLEM: The tissues of the human female reproductive tract (Fallopian tube, uterus, cervix, and vagina) may play different roles in provision mucosal immunity. purpose this study was to develop a uniform method suitable for quantitative comparison leukocytes from all these tissues. METHOD OF STUDY: Tissues, typically 0.5‐1.0 g, were dispersed by enzyme treatment. A flow cytometric gating procedure based on CD45‐positivity low far‐red autofluorescence permitted unfractionated, freshly cells...
The human female reproductive tract (RT) has been analyzed by others with respect to NK cell cytolytic activity, but not CD3+ T (CTL) activity. Here, we describe the capacity of mucosal cells both longitudinally within RT (Fallopian tube, uterine endometrium, endocervix, ectocervix, and vaginal mucosa) temporally throughout menstrual cycle, using a redirected lysis assay system. Cytolysis CD8+ is found appears be hormonally regulated, since in for activity present during proliferative phase...
Live-birth rates after treatment with assisted reproductive technology have traditionally been reported on a per-cycle basis. For women receiving continued treatment, cumulative success are more important measure.
Using confocal scanning laser microscopy of viable tissue sections, we have demonstrated organized lymphoid aggregates (LA), that a unique structure, in the stratum basalis uterine endometrium. These LA consist core B cells surrounded by more numerous T and an outer halo monocytes/ macrophages. The were almost exclusively CD8+CD4-. CD8+ LA, terms both their cell components, either small or absent during early proliferative stage menstrual cycle, significantly larger size at mid-cycle...
Background Assisted reproductive technology (ART) has been associated with birth defects, but the contributions of multiple births and underlying subfertility remain unclear. We evaluated effects mediation by on associations between ART nonchromosomal defects. Methods identified a retrospective cohort Massachusetts live stillbirths from 2004 to 2010 among ART‐exposed, ART‐unexposed subfertile, fertile mothers using linked information fertility clinics, vital records, hospital discharges,...
Do women with polycystic ovary syndrome (PCOS) have a greater risk of adverse pregnancy complications (gestational diabetes, preeclampsia, cesarean section, placental abnormalities) and neonatal outcomes (preterm birth, small for gestational age, prolonged delivery hospitalization) compared to without PCOS diagnosis does this vary by BMI, subfertility fertility treatment utilization?Deliveries history were at associated cardiometabolic function, including diabetes as well preterm birth...
How do the assisted reproductive technology (ART) outcomes of women presenting for ART after cancer diagnosis compare to without cancer? The likelihood a live birth among with prior using autologous oocytes is reduced and varies by but similar when donor are used. Premenopausal patients faced frequently present fertility preservation. Population-based cohort study treated in NY, TX IL, USA. Women their first treatment between 2004 2009 were identified from Society Assisted Reproductive...
To assess whether risk of severe maternal morbidity at delivery differed for women who conceived using assisted reproductive technology (ART), those with indicators subfertility but no ART ("subfertile"), and had neither nor ("fertile").This retrospective cohort study was part the larger Massachusetts Outcomes Study Assisted Reproductive Technology. construct Technology database identify deliveries, we linked treatment records to birth certificates infant hospitalization occurring in between...