About
Contact & Profiles
A5046451358
Research Areas
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Metabolism, Diabetes, and Cancer
École Polytechnique Fédérale de Lausanne
2023
Swiss Cancer Center Léman
2023
Abstract Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing progression. Here we examine metabolic adaptations of metastasis-initiating (MICs) female breast and how those shape their metastatic phenotype. We find endogenous MICs depend on oxidative tricarboxylic acid cycle fatty usage. Sorting tumor based upon solely mitochondrial membrane potential or lipid storage sufficient at identifying MICs. further identify mitochondrially-generated citrate...
10.1038/s41467-023-42748-8
article
EN
cc-by
Nature Communications
2023-11-04
Coming Soon ...