A5101915964- Immune Cell Function and Interaction
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Bone and Dental Protein Studies
- Gastrointestinal motility and disorders
- Cancer Research and Treatments
- IL-33, ST2, and ILC Pathways
- Barrier Structure and Function Studies
- Adenosine and Purinergic Signaling
- Effects of Radiation Exposure
- Mast cells and histamine
- Tryptophan and brain disorders
- Diet and metabolism studies
- Immune Response and Inflammation
Shuguang Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
Ningbo No. 2 Hospital
2020
Dartmouth College
2013-2016
Hanover College
2014-2015
Dartmouth Hospital
2014-2015
Bronx-Lebanon Hospital Center
2015
Polysaccharide A (PSA) derived from the human commensal Bacteroides fragilis is a symbiosis factor that stimulates immunologic development within mammalian hosts. PSA rebalances skewed systemic T helper responses and promotes regulatory cells (Tregs). However, PSA-mediated induction of Foxp3 in humans has not been reported. In mice, PSA-generated Foxp3+ Tregs dampen Th17 activity thereby facilitating bacterial intestinal colonization while increased presence function these may guard against...
Tolerance established by host-commensal interactions regulates host immunity at both local mucosal and systemic levels. The intestinal commensal strain Bacteroides fragilis elicits immune tolerance, least in part, via the expression capsular polysaccharide A (PSA). How such niche-specific microbial elements regulate extra-intestinal responses, as brain, remains largely unknown. We have recently shown that oral treatment with PSA suppresses neuro-inflammation elicited during experimental...
A classic herbal formula San-Wu-Huang-Qin (SWHQ) decoction has been widely used in clinical practices to prevent and treat colorectal cancer (CRC) for years, but its anti-tumorigenic properties the underlying mechanisms remain undetermined.The present study a CRC mouse model clarify whether how SWHQ suppresses tumorigenesis.Different doses of were gavaged AOM/DSS mice examine anti-tumor efficacy comparison with positive control drug Aspirin. The microbiota-driven action was proven bacterial...
Virus infection triggers a CD8+ T cell response that aids in virus clearance, but also expresses effector functions may result tissue injury. cells express variety of activating and inhibiting ligands, though regulation the expression inhibitory receptors is not well understood. The ligand for receptor, NKG2A, non-classical MHC-I molecule Qa1b, which serve as putative restricting element purported regulatory cells. We have previously shown Qa1b-null mice suffer considerably enhanced...
Background: Multiple sclerosis (MS) starts with increased migration of autoreactive lymphocytes across the blood-brain barrier. Transfer glatiramer acetate (GA) conditioned B cells leads to production immunoregulatory cytokines/chemokines and reduced CNS inflammation in EAE disease (Begum-Haque, 2011). There is evidence that CD44+ cell its ligand osteopontin (OPN) can play a critical role regulation MS/EAE. The deletion was shown mediate Th2-biased immune response Recently, others we have...
The gut accounts for 80[percnt] of immune cells and serves as an important reservoir both T B regulatory cell populations. interaction between the commensal microflora GALT is critical importance in a range experimental conditions including autoimmunity. functional properties derived lymphocyte populations phenotypic characteristics APCs EAE/MS are not fully understood. Alemtuzumab, humanized mAb that targets human CD52, significantly reduces risk relapse accumulation disability MS patients....
Abstract Background: Malnutrition threatened the clinical outcomes of colorectal cancer (CRC) by reducing patients’ responses to anti-cancer treatments and ultimately shortening thesurvival time. Recently malnutrition has been confirmed play an important role in CRC progress via gut microbiota. However, roles microbiota immunopathogenesis its underlying mechanisms remain inconclusive. Methods: Patient-Generated Subjective Global Assessment (PG-SGA) was performed determine nutrition status...