A5039438007- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Transcranial Magnetic Stimulation Studies
MIND Research Institute
2022-2023
Cornell University
2022-2023
Burke Medical Research Institute
2023
Weill Cornell Medicine
2022-2023
White Plains Hospital
2022
New York Proton Center
2022
Facilitating axon regeneration in the injured central nervous system remains a challenging task. RAF-MAP2K signaling plays key role elongation during development. Here, we show that conditional expression of constitutively kinase-activated BRAF mature corticospinal neurons elicited set transcription factors previously implicated zebrafish retinal ganglion cell axons and promoted sprouting tract (CST) after spinal cord injury mice. Newly collaterals formed synaptic connections with...
ABSTRACT Facilitating axon regeneration in the injured central nervous system remains a challenging task. RAF–MEK signaling plays an important role elongation during development. Here we show that activation of B-RAF mature corticospinal neurons elicited expression discrete set transcription factors previously implicated zebrafish optic nerve axons. Genetic B-RAF–MEK promoted robust and sprouting tract axons after injury. Newly collaterals formed synaptic connections with spinal...