A5004261699- Connective tissue disorders research
- Protease and Inhibitor Mechanisms
- Fibroblast Growth Factor Research
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Neuroscience and Neuropharmacology Research
- Cellular Mechanics and Interactions
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Medicinal Plants and Neuroprotection
- 14-3-3 protein interactions
- Ferroptosis and cancer prognosis
- Mechanisms of cancer metastasis
- Immune cells in cancer
- Nerve injury and regeneration
- Cancer Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Proteoglycans and glycosaminoglycans research
- Cholinesterase and Neurodegenerative Diseases
- Neurogenesis and neuroplasticity mechanisms
- Occupational and environmental lung diseases
- S100 Proteins and Annexins
- Supramolecular Self-Assembly in Materials
- Kruppel-like factors research
SUNY Upstate Medical University
2017-2022
Brigham and Women's Hospital
2013-2021
Harvard University
2013-2021
Cochin University of Science and Technology
2009-2013
Mass General Brigham
2013
The Ohio State University Wexner Medical Center
2012
Center for Neuro-Oncology
2012
Neurological Surgery
2012
Glioblastoma (GBM) is the most aggressive form of brain cancer, with a dismal prognosis and extremely low percentage survivors. Novel therapies are in dire need to improve clinical management these tumors extend patient survival. Genetic for GBM have been postulated attempted past twenty years, variable degrees success pre-clinical models trials. Here we review common approaches treat by gene therapy, including strategies deliver tumor-suppressor genes, suicide immunomodulatory cytokines...
Abstract Malignant gliomas are highly invasive and chemoresistant brain tumors with extremely poor prognosis. Targeting of the soluble factors that trigger invasion resistance, therefore, could have a significant impact against infiltrative glioma cells major source recurrence. Fibulin-3 is matrix protein absent in normal but upregulated promotes tumor by unknown mechanisms. Here, we show fibulin-3 novel activator Notch signaling antagonizes DLL3, an autocrine inhibitor or Notch, cell...
Spatial frequency domain imaging (SFDI) is a widefield technique that allows for the quantitative extraction of tissue optical properties.SFDI currently being explored small animal tumor imaging, but severe artifacts occur highly curved surfaces (e.g. edge).We propose modified Lambertian angle correction, adapted from Minnaert correction method satellite imagery, to account surface angles up 75°.The was tested in hemisphere phantom study as well model.The proposed reduced µ and s ` errors by...
High-grade gliomas are characterized by exuberant vascularization, diffuse invasion, and significant chemoresistance, resulting in a recurrent phenotype that makes them impossible to eradicate the long term. Targeting protumoral signals glioma microenvironment could have impact against tumor cells supporting niche facilitates their growth. Fibulin-3 is protein secreted cells, but absent normal brain, promotes invasion survival. We show here fibulin-3 paracrine activator of Notch signaling...
Abstract Background Tumor invasion, a hallmark of malignant gliomas, involves reorganization cell polarity and changes in the expression distribution scaffolding proteins associated with complexes. The DLG family are usually downregulated invasive tumors regarded as tumor suppressors. Despite their important role regulating neurodevelopmental signaling, functions have remained almost entirely unexplored gliomas. Methods Western blot, immunohistochemistry, analysis gene were used to quantify...
Purpose: We sought a novel approach against glioblastomas (GBM) focused on targeting signaling molecules localized in the tumor extracellular matrix (ECM). investigated fibulin-3, glycoprotein that forms ECM scaffold of GBMs and promotes progression by driving Notch NFκB signaling.Experimental Design: used deletion constructs to identify key motif fibulin-3. An mAb (mAb428.2) was generated this epitope extensively validated for specific detection human mAb428.2 tested cultures measure its...
Liver damage due to infection, cirrhosis, accidents and diseases lead destruction of hepatocytes their regeneration its original form is important for the proper functioning body. Gamma aminobutyric acid (GABA), a neurotransmitter, was coupled with biopolymer chitosan nanosized complexes were made. The morphology studied by scanning electron microscope interaction GABA analysed FT-IR spectroscopy. GABA-chitosan nanoparticles observed FITC labeled nanoparticles. After partial hepatectomy in...
Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis and limited therapeutic options. The extracellular matrix protein fibulin-3/EFEMP1 accumulates in the effusions of MPM patients has been proposed as a prognostic biomarker these tumors. However, it entirely unknown whether fibulin-3 plays functional role on growth progression. Here, we demonstrate that upregulated tissue, promotes malignant behavior cells, can be targeted to reduce Overexpression increased...
Parkinson's disease (PD) is due to widespread degeneration in the central and peripheral nervous systems. The hallmark pathology remains dopaminergic striatal insufficiency of neurons substantia nigra.The present study analysed effect serotonin (5-HT), dopamine, norepinephrine as treatment on rotenone induced hemi-Parkinson's rats its role regulation dopamine receptor subtypes corpus striatum experimental rats.Unilateral stereotaxic single-dose infusions were administered nigra adult male...