A5088851302- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- RNA modifications and cancer
- DNA Repair Mechanisms
- Nuclear Structure and Function
- Genomics, phytochemicals, and oxidative stress
- Bacterial biofilms and quorum sensing
- PI3K/AKT/mTOR signaling in cancer
- Bioactive natural compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Cholesterol and Lipid Metabolism
- Cancer-related Molecular Pathways
- Fungal Plant Pathogen Control
- Bacterial Genetics and Biotechnology
- ATP Synthase and ATPases Research
Duke University
2021
University of Kerala
2016
Medizinische Hochschule Hannover
2011
The TREX (transcription/export) complex has been conserved throughout evolution from yeast to man and is required for coupled transcription elongation nuclear export of mRNAs. in mammals Drosophila composed the THO subcomplex (THOC1, THOC2, THOC5, THOC6, THOC7), THOC3, UAP56, Aly/THOC4. In human , various studies have shown that heat shock mRNAs, but nothing known about other Our previous study using conditional THOC5 (or FMIP ) knockout mice revealed presence critical hematopoietic cells...
In response to DNA damage, transcription is blocked by inhibition of RNA polymerase II activity. The regulation a preexisting pool mRNAs, therefore, plays key role in repair, cell cycle arrest, or differentiation. THOC5 member the THO complex and export subset mRNA, which an important hematopoiesis maintaining primitive cells. Since three serine residues PEST domain have been shown be directly phosphorylated ataxia-telangiectasia-mutated (ATM) kinase, we examined THOC5-dependent mRNA under...
Combating single and multi-drug-resistant infections in the form of biofilms is an immediate challenge. The challenge to discover innovative targets develop novel chemistries that combat drug-resistant organisms, thwart emergence future resistant strains. An ideal target would control multiple genes, can be inhibited by a compound. We previously demonstrated success against Staphylococcus aureus targeting tRNA-dependent regulated T-box not present human host. Present Gram-positive bacteria,...
Human Genome Wide Association Studies found a significant risk of Type 2 Diabetes Mellitus (T2DM) in single nucleotide polymorphisms the cdkal1 gene. The gene is remote from insulin and with surprising function specific tRNA modification. Population studies case control acquired evidences connection between Cdkal1 protein production over years. To obtain biochemical proofs directly linking potential SNPs to their roles availability challenging, but development knock out mice cell lines made...
The primary objective of the project is to develop a cell culture model that mimics pancreatic beta islets study biochemical consequences single nucleotide polymorphisms (SNPs) found in intron-5 cdkal1 gene which codes for tRNA modification enzyme. SNPs has been pointed out its role development Type 2 Diabetes Mellitus (T2DM) from past few years by human Genome Wide Association Studies. Still we lack system investigate mutations result unprocessed, non-functional insulin leading T2DM....