A5086791773- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Advanced Drug Delivery Systems
- Osteoarthritis Treatment and Mechanisms
- Phytochemical compounds biological activities
- Peptidase Inhibition and Analysis
- thermodynamics and calorimetric analyses
- Essential Oils and Antimicrobial Activity
- Inflammatory mediators and NSAID effects
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Proteoglycans and glycosaminoglycans research
- Analytical Chemistry and Chromatography
- Advancements in Transdermal Drug Delivery
- Mesoporous Materials and Catalysis
- Drug Transport and Resistance Mechanisms
- Clay minerals and soil interactions
Misr University for Science and Technology
2022-2024
IBM (Egypt)
2024
Abstract The solid dispersion technique is the most effective and widely used approach for increasing solubility release of drugs that have low water solubility. Mirtazapine (MRT) an atypical antidepressant to treat severe depression. MRT has a oral bioavailability (about 50%) due its (BCS class II). study’s goal was determine optimum conditions incorporating into various polymer types utilizing (SD) technique, with selecting suitable formula optimal aqueous solubility, loading efficiency,...
Employment of mesoporous silica nanostructures (MSNs) in the drug delivery field has shown a significant potential for improving oral active pharmaceutical products with low solubility water. Mirtazapine (MRT) is tetracyclic antidepressant poor water (BCS Class II), which was recently approved as potent used to treat severe depression. The principle this research optimize incorporation into MSNs improve its aqueous solubility, loading efficiency, release performance, and subsequent...
Abstract The majority of conventional osteoarthritis (OA) treatments are based on molecular adjustment certain signaling pathways associated with pathogenesis, however there is a significant need to search for more effective and safe treatments. This study centers around formulating Aceclofenac (ACF) high bioavailability in combination Citronellol oil collagen. optimal concentrations oil/D-Limonene oil, Tween 80, Transcutol HP were determined using pseudoternary phase diagram. formulated...
Telmisartan (Tel) is a potent antihypertensive drug with very poor aqueous solubility, especially in pH ranging from 3 to 9 (i.e., biological fluids) that results bioavailability. Our aim was improve Tel solubility and dissolution rates without the need for expensive multistep procedures, inclusion of alkalinizers. This study adopted use surface solid dispersions (SSDs) employing superdisintegrants, hydrophilic polymers combined carriers including superdisintegrant polymer. Tel-SSDs were...
Aceclofenac (ACF) is a widely used non-steroidal anti-inflammatory drug (NSAID) known for its effectiveness in treating pain and inflammation. Recent studies have demonstrated that ACF possesses antiproliferative properties, inhibiting the growth of cancer cells various cell lines. Citronellol, monoterpenoid alcohol found essential oils, exhibits antioxidant properties activities such as acetylcholinesterase inhibition. In this study, objective was to formulate evaluate an...
Targeted drug delivery is achieving great success in cancer therapy due to its potential deliver drugs directly the action site. Terbinafine hydrochloride (TER) a broad-spectrum anti-fungal that has been found have some anti-tumor effects treatment of colon cancer. We aimed here design and develop pH-sensitive Eudragit (Eud)-coated mesoporous silica nanostructures (MSNs) control release response changes pH. The diffusion-supported loading (DiSupLo) technique was applied for TER into MSNs....
The approval of leukotriene antagonists like montelukast and antihistamines such as fexofenadine has opened up new possibilities for the treatment prevention asthma allergic rhinitis.It been observed that combining both drugs concurrently yields more favorable results compared to using them individually.In light this, aim this study was develop, evaluate, perform a pharmacokinetic analysis single-dose tablet containing sodium (a antagonist) hydrochloride (an antihistamine).The goal enhance...
Hepatic first-pass metabolism has been a major cause of reduced bioavailability for many drugs. Using the nasal route as an alternative to deliver drugs systemic circulation provided solution this problem. One which are highly affected by is itopride hydrochloride (ITO HCl). It prokinetic agent used treatment various gastrointestinal motility disorders, mainly gastroesophageal reflux. The objective study was determine pharmacokinetic parameters selected mucoadhesive in situ gel formulations...