A5007487600- Evolution and Genetic Dynamics
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Microbial Community Ecology and Physiology
- Pharmaceutical and Antibiotic Environmental Impacts
- Evolutionary Game Theory and Cooperation
- Hormonal Regulation and Hypertension
- Biocrusts and Microbial Ecology
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Vibrio bacteria research studies
- Gene Regulatory Network Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Slime Mold and Myxomycetes Research
- Bacterial Genetics and Biotechnology
- Diagnosis and Treatment of Venous Diseases
- Bacteriophages and microbial interactions
- Reproductive System and Pregnancy
- Ovarian function and disorders
- Adaptive Control of Nonlinear Systems
- Endometriosis Research and Treatment
- Thermoregulation and physiological responses
- Sensorless Control of Electric Motors
- Pressure Ulcer Prevention and Management
- Advanced Algorithms and Applications
Swiss Federal Institute of Aquatic Science and Technology
2021-2024
Nanchang University
2023-2024
University of Bern
2022-2023
ETH Zurich
2021-2023
University of Illinois Urbana-Champaign
2020
Abstract Plasmids are the main vector by which antibiotic resistance is transferred between bacterial cells within surface-associated communities. In this study, we ask whether there an optimal time to administer antibiotics minimize plasmid spread in new genotypes during community expansion across surfaces. We address question using consortia of Pseudomonas stutzeri strains, where one resistance-encoding donor and other a potential recipient. allowed strains co-expand surface administered...
Surface-associated microbial systems are hotspots for the spread of plasmid-encoded antibiotic resistance, but how surface association affects plasmid transfer and proliferation remains unclear. Surface enables prolonged spatial proximities between different populations, which promotes them. However, also fosters strong metabolic interactions can direct their self-organization with consequences proliferation. Here, we hypothesize that populations and, in turn, regulate resistance. We show...
Microbes are social organisms that commonly live in sessile biofilms. Spatial patterns of populations within biofilms can be important determinants community-level properties. intermixing emerging from microbial interaction is one the best-studied characteristics spatial patterns. The specific levels critically contribute to how dynamics and functioning such communities governed. However, precise factors determine remain unclear. Here, we investigated patterning an engineered synthetic...
Abstract The spread of antibiotic resistance (AR) is a major threat to global health. Plasmid-mediated horizontal gene transfer the main mechanism by which AR transferred between cells lying within close spatial proximity each other. In this study, we address fundamental question regarding AR-encoding plasmids: Is there an optimal time administer antibiotics minimize plasmid microbial communities? We addressed using consortia consisting two Pseudomonas stutzeri strains, where one donor and...
Polycystic ovary syndrome (PCOS) is an endocrine disorder and metabolic syndrome. Ovarian fibrosis pathological change in PCOS has gradually attracted people's attention. In this study, we constructed a mouse model through the use of dehydroepiandrosterone. Sirius red staining showed that ovarian tissues mice had obvious fibrosis. Prolyl oligopeptidase (POP) serine protease N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) its catalytic product. Studies show abnormal expression activity POP...
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Chronic stress has become a major problem that endangers people’s physical and mental health. Studies have shown chronic impairs female reproduction. However, the related mechanism is not fully understood. P2X7 receptor (P2X7R) involved in variety of pathological changes induced by stress. Whether P2X7R effect on reproduction been studied. In this study, we established restraint mouse model cold model. We found number corpora lutea was significantly reduced two models. The indirectly...
Abstract Surface-associated microbial communities are omnipresent on Earth. As individuals grow and divide within these communities, they undergo range expansion during which different cell-types arrange themselves across space to form spatial patterns (referred as self-organization). Metabolic interactions important determinants of the self-organization process, where direct positionings cell-types. We hypothesized here a previously unexplored consequence metabolic interactions; by...
Abstract Polycystic ovary syndrome (PCOS) is an endocrine disorder and metabolic syndrome. Ovarian fibrosis pathological change in PCOS gradually attracted people’s attention. In this study, we constructed mice model through dehydroepiandrosterone. Sirius red staining showed that the ovarian tissues had obvious fibrosis. Prolyl oligopeptidase(POP) a serine protease N-acetyl-Seryl-aspartyl-Lysyl-proline (Ac-SDKP) its catalytic products. Studies show abnormal expression activity of POP Ac-SDKP...
Abstract The horizontal transfer of plasmids is an important driver microbial evolution, such as conferring antibiotic resistance (AR) to new genotypes. In biofilms, the abundance cell-cell contacts promotes frequent and their associated genes. this study, we expand our knowledge about AR-encoding by investigating between discrete biofilms grow physically collide with each other. Using experimental system consisting two fluorescently labelled Pseudomonas stutzeri strains Escherichia coli...
Abstract Plasmids are the main vector by which antibiotic resistance (AR) is transferred between bacterial cells within surface-associated communities. In this study, we ask whether there an optimal time to administer antibiotics minimize plasmid spread in new genotypes during community expansion across surfaces. We addressed question using consortia of two Pseudomonas stutzeri strains, where one AR-encoding donor and other a potential recipient. allowed strains co-expand surface...
Microorganisms are the most biodiverse life forms on our planet, yet we know little about spatial processes underlying their ecology and evolution. Here, highlight importance of two that act individual cells - intermixing different populations mechanical cell shoving during growth to improve understanding microbial eco-evolutionary dynamics. Using an individual-based model, show coexistence slow- fast-growing becomes highly constrained under conditions: when spatially intermixed ability...
<p>Biofilms are considered as hotspots for the transfer of antibiotic resistance genes (ARGs), but very few studies have investigated fate ARGs (e.g. proliferation or elimination) in situ given different microbial spatial self-organization (SSO). SSO refers to a pervasive process during biofilm formation when microbes arrange themselves non-randomly across surfaces. So far causes been uncovered sense, however, consequences were largely overlooked. Here, I hypothesize that...
Microorganisms are the most biodiverse life forms on our planet, yet we know little about spatial processes underlying their ecology and evolution. Here, highlight importance of two that act individual cells - intermixing different populations mechanical cell shoving during growth to improve understanding microbial eco-evolutionary dynamics. Using an individual-based model, show coexistence slow- fast-growing becomes highly constrained under conditions: when spatially intermixed ability...
Abstract Microbes are social organisms that commonly live in sessile biofilms. Spatial patterns of populations within biofilms can be an important determinant community-level properties. The best-studied characteristics spatial is intermixing different populations. specific levels critically contribute to how the dynamics and functioning such communities governed. However, precise factors determine remain unclear. Here, we investigated patterning engineered synthetic consortium composed two...